Mark F. Coughlin
Reserch ScientistEmail: email@example.com
Department: Biological Engineering
|Research summary:The goal of my project is to garner a better understanding of cancer progression by
bringing together well-characterized cellular model systems with novel microfluidic
platforms developed in our laboratory. Focusing on the processes of intravasation
and extravasation, I will directly visualize the interaction of individual cancer cells
with microvascular endothelial cells at unmatched spatial and temporal resolution.
This approach will be adapted to determine, for the first time, the molecular basis of
force generation within cancer cells crossing the endothelium, the fate of
extravasated cells in the extravascular space, and the biophysical adaptations that
enhance metastatic ability.