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  Research Fellows And Research Projects  
  Project abstracts can be viewed from the CD-ROM which is enclosed or the SMA website (http://www.sma.nus.edu.sg).  
     
  AMM&NS Programme HPCES Programme IMST Programme MEBCS Programme  
  CS Programme        
     
  MEBCS Programme  
     
 
DR PARAYIL KUMARAN AJIKUMAR
Expertise: Design, synthesis, and structure activity study of biologically active molecules such as peptides and peptido mimetic compounds, solid phase peptide synthesis, solid phase organic synthesis, Protein and peptide micro arrays and combinatorial chemistry
     
Design, Development and Functional Analysis of a Spatially Addressable Protein Microarray
     
Project Advisor
(Singapore)
:
Assoc Prof Too Heng-Phon
     
Duration :
March 2003 to March 2006
     
 
 

Project Abstract:

The advances in the modern proteomic research were highlighted by the exploration and adoption of many new techniques and strategies which provided the potential for the simultaneous study of thousands of proteins in a single experiment. Among them high-throughput array technique could provide an important tools to probe the complex analytes such as serum, whole blood and total cell extracts. Thus these emerging techniques are capable of revealing novel protein functions and helping in a better understanding of comprehensive protein interaction networks in an organism. As like any other emerging technology, the protein micro array also showed great potential, but the difficulties of reducing “exciting theory” to “real-life practice” is an unyielding problem. The present project will address some of the existing problems and would eventually develop a novel platform for the generation and arraying of a large pool of protein into a spatially addressable format with multiplexed screening in a highly miniaturized format.

 
     
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