Research in MechanoBiology Laboratory
An overriding objective of the Mechanobiology Lab is to elucidate the fundamental nature of how cells sense and respond to mechanical stimuli, and to employ the principles revealed by these studies to seek new treatments for vascular disease and to develop tissue constructs for drug and toxicity screening.
Both experimental and computational approaches are employed in a manner that encourages the constant interplay between the two for purposes of model validation, direct measurement of critical parameters, and identifying new hypotheses to be tested through experiment.
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Biological machines / Microfluidics
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Wan C.R., Chung S., Kamm R.D. (2011) “Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system.” Ann. Biomed. Eng.1840-7.
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Angiogenesis / Vasculogenesis
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Vickerman, V., Blundo, J., Chung, S., and Kamm, R. (2008) "Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging." Lap Chip 8(9): 1468-1477.
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Cancer
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Zervantonakis I.K., Kothapalli C.R., Chung S., Sudo R., Kamm R.D. (2011) “Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments.” Biomicrofluidics. 5(1):13406.
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Simulation and modeling
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Kim T., Hwang W., Lee H., Kamm R.D. (2009). “Computational analysis of viscoelastic properties of crosslinked actin networks.” PLoS Comput. Biol. 5(7):e1000439.
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Molecular mechanics
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Lee, S.E., Chunsrivirot, S., Kamm, R.D., and Mofrad M.R. (2008) "Molecular Dynamics Study of Talin-Vinculin Binding." Biophys J 95: 1-10.
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Infectious diseases
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Caption needed.
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