Sharon Lee Graduate student Email: sleewl@u.nus.eduFocus group: Microfluidics, Monocytes, Confocal microscopy Department: Singapore-MIT Alliance for Research & Technology Hometown: Undergrad: |
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| Research summary:
My project is to develop a 3D tumor model with a myeloid component and to focus on
unravelling the role of monocytes/macrophages (mno/macs) in cancer progression.
Mno/macs are attractive therapeutic targets because they are capable of adopting a broad
spectrum of phenotypes depending on the stimuli of their environment. One study revealed
that in a model of the intrahepatic carcinoma environment, mnos had a differential effect on
differently engineered T cells. To build on that study, I intend to modify that model by adding
tumour interstitial flow to evaluate its impact on the pro-tumour behaviour of mnos/macs and
the corresponding response of tumour cells in the co-culture.
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 HepG2-preS1-GFP spheroid surrounded by TCR-redirected T cells (in blue) and monocytes (in pink). Dead cells are labelled by DRAQ7 (in red). | ||
Research achivement: |
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