Huu Tuan Nguyen

Postdoctoral fellow

Focus group: 1&2
Department: Biological Engineering
Research summary:
I study the role of tumor-associated macrophage (TAM) in cancer metastasis and immune response by designing and then employing a microfluidic system that can mimic the tumor microenvironment. The microfluidic device contains perfusable vascular networks that host a tumor spheroid. In this system, tumor cells are cocultured with several cell types in the tumor microenvironment such as fibroblasts, macrophages, endothelial cells. Using this platform, I characterize several early metastasis steps such as tumor cells migration, angiogenesis and tumor cell intravasation by performing 3D image processing. Currently, I focus on immunotherapy treatments targeting TAMs and their effect on cancer metastasis. I will investigate the effect of macrophage treatment on angiogenesis, tumor cell migration and immune cell recruitments.


Research achievement:
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