1. Gruner, S.M., Tate, M.W., Kirk, G.L., So, P.T.C., Turner, D.C., and Keane, D.T., "X-ray Diffraction Study of Polymorphic Behavior of N-Methylated Dioleoylphosphatidylethanolamine," Biochemistry, 27, 2853-2866 (1988).

2. Shyamsunder, E., Gruner, S.M., Tate, M.W., Turner, D.C., and So, P.T.C., "Observation of Inverted Cubic Phase in Hydrated Dioleoylphosphatidylethanolamine," Biochemistry, 27, 2332-2336 (1988).

3. Narayan, O., So, P.T.C., Turner, D.C., Gruner, S.M., Tate, M.W., and Shyamsunder, E., "Volume Constriction of Lipid-water Liquid Crystal Using High Pressure X-ray Diffraction," Physical Review A, 42, 7479-7482 (1990).

4. So, P.T.C., Gruner, S.M., and Shyamsunder, E., "Automated Pressure and Temperature Control Apparatus for X-ray Powder Diffraction Studies," Review of Scientific Instruments, 63, 1763-1770 (1992).

5. So, P.T.C., Gruner, S.M., and Shyamsunder, E., "High Pressure Dilatometer," Review of Scientific Instruments, 63, 5426-5431 (1992).

6. So, P.T.C., Gruner, S.M., and Shyamsunder, E., "Pressure Induced Topological Phase Transitions in Membranes," Physics Review Letter, 70, 3455-3458 (1993).

7. Osterberg, F., Kriechbaum, U., Polcyn, A., Skita, V., Tate, M.W., So, P.T.C., Gruner S.M., and Shyamsunder, E., "Pressure Induced Hydration Dynamics of Membranes," Physics Review Letter, 72, 2967-2970 (1994).

8. Berland, K.M., So, P.T.C., and Gratton, E., "Two-photon Fluorescence Spectroscopy: Method and Application to the Intracellular Environment," Biophys. J. 68, 694-701 (1995).

9. Dong, C.Y., So, P.T.C., French, T., and Gratton, E., "Fluorescence Lifetime Imaging by Asynchronous Pump-probe Microscopy: Application to Cellular Systems," Biophys. J. 69, 2234-2242 (1995).

10. Fishkin, J.B., So, P.T.C., Cerussi, A.E., Fantini, S., Franceschini, M.A., and Gratton, E., "A Frequency-domain Method for Measuring Spectra Properties in Multiple Scattering Media: Methemoglobin Absorption Spectrum in a Tissue-like Phantom," Applied Optics, 34 (7), 1143-1155 (1995).

11. So, P.T.C., French, T., Yu, W., Berland, K.M., Dong, C.Y., and Gratton E., "Time-resolved Fluorescence Microscopy Using Two-photon Excitation," Bioimaging, 3, 49-63 (1995).

12. Berberan-Santos, M.N., Canceill, J., Gratton, E., Jullien, L., So, P.T.C., Sutin, J., and Valeur B., "Multichromophoric Cyclodextrins. 3. Investigation of Dynamics of Energy Hopping by Frequency-Domain Fluorometry," J. Phys. Chem., 100, 15-20 (1996).

13. Berland, K.M., So, P.T.C., Chen, Y., Mantulin, W.W. and Gratton, E., "Scanning Two-photon Fluctuation Correlation Spectroscopy: Particle Counting Measurement for Detection of Molecular Aggregation," Biophysical J., 71, 410-420 (1996).

14. Koenig, K., So, P.T.C., Mantulin, W.W., Tromberg, B.J. and Gratton, E., "Two-photon Excited Lifetime Imaging of Autofluorescence in Cells During UVA and NIR Photostress," J. Microscopy, 183, 197-204 (1996).

15. Yu, W.M., So, P.T.C., French, T., and Gratton, E., "Fluorescence Polarization of Cell Membrane-A Two-photon Scanning Microscopy Approach," Biophys. J., 70, 626-636 (1996).

16. Dong, C.Y., So, P.T.C., and Gratton, E., "Spatial Resolution in Pump-probe Microscopy," Optik, 106, 7-14 (1997).

17. French, T., So, P.T.C., Carrero, J., Weaver, D.J. Jr., Cherukuri, A., Zoelho-Sampaio, T., Gratton, E., and Voss, E., "Macrophage Mediated Processing of An Exogenous Probe: Elucidation of Probe Processing with Two-photon Fluorescence Microscope with Time-resolved and Intensity Imaging," J. Microscopy, 185, 339-353 (1997).

18. Koenig, K., So, P.T.C, Mantulin, W.W., and Gratton, E., "Cell Damage in Two-photon Femtosecond Microscopes," Applied Optics, 22, 135 (1997).

19. Masters, B., So, P.T.C., and Gratton, E., "Three-Dimensional Two-photon Excitation Fluorescence Microscopy and Spectroscopy of In Vivo Human Skin," Biophys J., 72, 2405-2412 (1997).

20. French, T., So, P.T.C., Dong, C.Y., Berland, K.M., and Gratton, E., "Fluorescence lifetime imaging technique for microscopy," Meth.Cell. Biol., 56, 277-304 (1998).

21. Masters, B.R., So, P. and Gratton, E., "Optical Biopsy of In Vivo Human Skin: Multi-photon Excitation Microscopy," Lasers in Medical Science, 13, 197-204 (1998).

22. So, P.T.C., Kim, H., Kochevar, I.E., "Two-photon Deep Tissue Ex Vivo Imaging of Mouse Dermal and Subcutaneous Structures," Optics Express, 3, 339-350 (1998).

23. So, P.T.C., "Prospects of Nonlinear Microscopy in the Next Decade: An Overview," Optics Express, 3, 312-314 (1998).

24. So, P.T.C., Koenig, K., Berland, K.M., Dong, C.Y., French, T., Buhler, C., Regan, T., and Gratton, E., "New Time-resolved Techniques in Two-photon Microscopy," Cellular and Molecular Biology, 44, 771-73 (1998).

25. Buehler, C., Kim, K.H., Masters, B.R., So, P.T.C., Kochevar, I.E., Gratton, E., "Two-photon Deep Tissue Imaging," IEEE Engineering in Medicine and Biology Magazine, 18, 23-30 (1999).

26. Chen, Y., Muller, J.D., So, P.T.C., Gratton, E., "The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy," Biophys. J., 77, 553-67 (1999).

27. Farrer, R.A., Previte, M.J.R., Olson,C.E., Peyser, L.A., Fourkas, J.T., and So, P.T.C., "Single-molecule detection with a two-photon fluorescence microscope with fast-scanning capabilities and polarization sensitivity," Opt. Lett., 24, 1832-1834 (1999).

28. Kim, K.H., Buehler, C., So, P.T.C., "High Speed Two-photon Scanning Microscopy," Applied Optics, 38, 6004-6009 (1999).

29. Masters, B.R., So, P.T.C., Kim, K.H., Buehler, C., and Gratton, E., "Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo," Methods Enzymol., 307, 513-536 (1999).

30. Masters, B.R., So, P.T.C., Gratton, E., Gonnord, G., Corcuff, P., "Microscopy of Human Skin In Vivo: Multi-photon Excitation Microscopy and Confocal Microscopy," Microscopy and Microanalysis, 5, 282-289 (1999).

31. Masters, B.R., So, P.T.C. and Gratton, E., "Multi-photon Excitation Microscopy and Confocal Microscopy of Human Skin In Vivo," Comments on Molecular and Cellular Biophysics, 9, 379-405 (1999).

32. Riegler, M., Castagliuolo, I., So, P.T.C., Lotz, M., Wang, C., Wlk, M., Sogukoglu, T., Cosentini, E., Bischof, G., Hamilton, G., Teleky, B., Wenzl, E., Matthews, J.B., and Pothoulakis, C., "Effect of Substance P on Human Colonic Mucosa In Vitro," American Journal of Physiology: Gastrointestinal and Liver Physiology, 276, G1473-83, (1999).

33. Cragg, G. and So, P.T.C., "Standing-Wave Total Internal Reflection Microscopy," Opt. Lett., 25, 46-48 (2000).

34. Buehler, C., Dong, C.Y., So, P.T.C., and Gratton, E., "Time-resolved polarization imaging by pump-probe (stimulated emission) fluorescence microscopy," Biophys. J., 79, 536-549 (2000).

35. Frolov, A., Petrescu, A., Atshaves, B.P., So, P.T.C., Gratton, E., Serrero, G., and Schroeder, F., "High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single- and multiphoton fluorescence approach," J. Biol. Chem., 275, 12769-12780 (2000).

36. Gilbert, R.J., Hoffman, M., So, P.T.C., "Imaging of three-dimensional epithelial architecture and function in cultured CaCo2a monolayers with two-photon excitation microscopy," Micro. Res. Tech., 51, 204-210 (2000).

37. So, P.T.C., Dong, C.Y., Masters, B.R., and Berland, K.M., "Two-Photon Excitation Fluorescence Microscopy," Ann. Rev. Biomedical Eng., 2, 399-429 (2000).

38. So, P.T.C., "Two-Photon Fluorescence Microscopy: A New Tool for Tissue Imaging and Spectroscopy," Histotechnology, 23, 221-228 (2000).

39. Dong, C. Y., Buehler, C., So, T. C., French, T., Gratton, E., "Implementation of intensity-modulated laser diodes in time-resolved, pump-probe fluorescence microscopy," Applied Optics, 40,1109-1115(2001).

40. Huang, H., Kamm, R. D., So, P. T. C., Lee, R. T., "Receptor-based differences in human aortic smooth muscle cell membrane stiffness," Hypertension, 38,1158-61(2001).

41. Masters, B.R., and So, P.T.C., "Confocal Microscopy and Two-Photon Excitation Microscopy of Human Skin In Vivo," Opt. Exp., 8, 2-10 (2001).

42. Napadow, V. J., Chen, Q., Mai, V., So, P. T. C., Gilbert, R. J., "Quantitative analysis of three-dimensional-resolved fiber architecture in heterogeneous skeletal muscle tissue using nmr and optical imaging methods," Biophys J, 80,2968-75(2001).

43. So, P. T. C., Kwon, H. S., Dong, C. Y., "Resolution enhancement in standing-wave total internal reflection microscopy: a point-spread-function engineering approach," J Opt Soc Am A Opt Image Sci Vis, 18,2833-45(2001).

44. Yu B., Dong C. Y., So P. T. C., Blankschtein D., Langer R., "In vitro visualization and quantification of oleic acid induced changes in transdermal transport using two-photon fluorescence microscopy," J Invest Dermatol, 117,16-25(2001).

45. Huang, H., Dong, C. Y., Kwon, H. S., Sutin, J. D., Kamm, R. D., So, P. T. C., "Three-Dimensional Cellular Deformation Analysis with a Two-Photon Magnetic Manipulator Workstation," Biophys J, 82,2211-2223(2002).

46. So, P.T.C., "Two-photon Fluorescence Light Microscopy," Encyclopedia of Life Sciences, In press.

47. So, P.T.C., "Fluorescence Spectrophotometry", Encyclopedia of Life Sciences, In press.

48. Yu B, Kim KH, So PTC, Blankschtein D, Langer R. "Topographic heterogeneity in transdermal transport revealed by high-speed two-photon microscopy: Determination of representative skin sample sizes", J. Invest. Dermatol., 118(6): 1085-1088 (2002)

49. Yu B., Kim K.H., So P.T.C., Blankschtein D., Langer R. "Evaluation of fluorescent probe surface intensities as an indicator of transdermal permeant distributions using wide-area two-photon fluorescence microscopy:, J Pharm Sci-US, 92 (12): 2354-2365 (2003)

50. Dong C.Y., Koenig K., So P. "Characterizing point spread functions of two-photon fluorescence microscopy
in turbid medium", J Biomed Opt, 8 (3): 450-459 (2003)

51. Ragan T.M., Huang H., So P.T.C. "In vivo and ex vivo tissue applications of two-photon microscopy", Method Enzymol, 361: 481-505 (2003)

52. Yu B., Kim K.H., So P.T.C., Blankschtein D., Langer R. "Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy", J Invest Dermatol, 120 (3): 448-455 (2003)

53. Masters B.R., So P.T.C. "Antecedents of two-photon excitation laser scanning microscopy", Microsc Res Techniq, 63 (1): 3-11 (2004)

54. Dong C.Y., Yu B., Kaplan P.D., So P.T.C. "Performances of high numerical aperture water and oil immersion objective in deep-tissue, multi-photon microscopic imaging of excised human skin", Microsc Res Techniq, 63 (1): 81-86 (2004)

55. Tschumperlin D.J., Dai G., Maly I.V., Kikuchi T., Laiho L.H., McVittie A.K., Haley K.J., Lilly C.M., So P.T.C., Lauffenburger D.A., Kamm R.D., Drazen J.M. "Mechanotransduction through growth-factor shedding into the extracellular space", Nature, in press (2004)

1. Mantulin, W.W., Fishkin, J.B., So, P.T.C., Gratton E., and Maier, J.S., "Quantitative Diffusive Wave Spectroscopy in Tissues," Los Angeles, CA, SPIE Proc., 1888, 420-427 (1993).

2. So, P.T.C., French, T., and Gratton, E., "A Frequency Domain Time-resolved Microscope Using a Fast-scan CCD Camera," Time-resolved Laser Spectroscopy IV: Biochemistry IV at Biomedical Optics '94, Los Angeles, CA, 1994,SPIE Proc. 2137, pp. 83-92.

3. Gratton, E., Dong, C.Y., and So, P.T.C., "Fluorescence Lifetime Microscopy: A Stimulated-emission Approach," Functional Imaging and Optical Manipulation Of Living Cells at Biomedical Optics '95, San Jose, CA, SPIE Proc, 2678, 98-109 (1996).

4. Koenig, K., Liang, H., Kimel, S., Svaasand, O., Tromberg, B.J., Krasieva, T.B., Berns, M.W., Halbhuber, K.J., So, P.T.C., Mantulin, W.W., and Gratton, E., "Cell Damage in UVA and CW/Femtosecond NIR Microscopes," Functional Imaging and Optical Manipulation Of Living Cells at Biomedical Optics '96, San Jose, CA, SPIE Proc, 2983, 37-44 (1997).

5. So, P.T.C., Ragan, T., Gratton, E., Carrero, J., Voss, E., "Two-photon Single Particle Tracking in 3-D," Functional Imaging and Optical Manipulation Of Living Cells at Biomedical Optics '96, San Jose, CA, SPIE Proc, 2983, 45-56 (1997).

6. So, P.T.C., Duggar, K.H., Berland, K.M., and Gratton, E., "Generating an Intracellular Diffusion Map by Two-photon Fluorescence Correlation Spectroscopy, Boston, MA , Material Science of the Cell. Symposium Material Research Society, (1997).

7. Kim, K.H., So, P.T.C., Kochevar, I.W., Masters, B.R., Gratton, E., "Two-photon Fluorescence and Confocal Reflected Light Imaging of Thick Tissue Structures," Functional Imaging and Optical Manipulation Of Living Cells at Biomedical Optics '98, San Jose, CA, SPIE Proc, 3260, 46-57 (1998).

8. Masters, B.R., So, P.T.C., Gratton, E., "Multi-photon Excitation Microscopy of In Vivo Human Skin: Functional and Morphological Optical Biopsy Based on Three-dimensional Imaging, Lifetime Measurements and Fluorescence Spectroscopy," New York, N.Y., Annals New York Academy of Science, 838, 58-67 (1998).

9. Masters. B.R., So, P.T.C., Mantulin, W.W., Gratton, E., "Tissue Microscopy and Spectroscopy: A Two-photon Approach," Trends in Optics and Photonics: Biomedical Optical Spectroscopy and Diagnostics, Orlando, FL, Optical Society of America Proc., 43-46 (1998).

10. So, P.T.C., Masters, B.R., Gratton, E., Kochevar, I.E., "Two-photon Optical Biopsy Of Thick Tissues," Trends in Optics and Photonics: Biomedical Optical Spectroscopy and Diagnostics, Orlando, FL, Optical Society of America Proc., 40-42 (1998).

11. Buehler, C., Dong, C.Y., So, P.T.C., Gratton, E., "Frequency-domain, Pump-probe Microscopic Imaging Using Intensity Modulated Laser Diodes," Advanced Assay Technology for Drug Discovery, Biomedical Optics '99, San Jose, CA, SPIE Proc., 3603, 262-217 (1999).

12. So, P.T.C., "Two-Poton Video Rate Microscopy," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics '99, San Jose, CA, SPIE Proc. 3604, 60-66 (1999).

13. Wallace, V.P., Dunn, A. Coleno, M., So, P.T.C., Tromberg, B.J., "Study of the Spatial Point Spread Function with Depth in Two-photon Microscopy," Three Dimensional and Multi-Dimensional Microscopy: Image Acquistion and Processing VI, Biomedical Optics '99, San Jose, CA, SPIE Proc., 3604, 67-73 (1999).

14. Brenan, C.J. and So, P.T.C., "Two-photon fluorescence confocal microscopy with a passively Q-switched Nd:YAG microchip laser," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2000, San Jose, CA, SPIE Proc., In press.

15. Dong, C., Huang, H., Cragg, G., Lee, R.T., Kamm, R.D., Lauffenburger, D.A. and So, P.T.C., "Magnetic tweezer microscopy for cellular manipulation," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2000, San Jose, CA, SPIE Proc., In press.

16. Dong, C.Y., Hsu, L., Bevin, E., Koenig, K., So, P.T.C., "Characterization of two-photon point spread function in turbid medium by direction measurement, blind deconvolution, and multicolor imaging," Multiphoton microscopy in the biomedical sciences, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

17. Hsu, L., Berland, K., Hancewicz, T.M., Kaplan, P.D., and So, P.T.C., "Two-photon excitation spectral analysis of ex-vivo human skin," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

18. Huang, H, Dong, C.Y., Kwon, H., Sutin, J.D., Kamm, R.D., Lee, R.T., and So, P.T.C., "Cellular biomechanics using magnetic tweezers and two-photon microscopy," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

19. Kim, K., Engelward, B.P., and So, P.T.C., "Applying high-throughput two-photon microscopy for the detection of genetic instability in mice," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

20. Masters, B.R. and So, P.T.C., "Multiphoton microscopy of human skin in vivo: Early development of an optical biopsy," Optical Technology in Biophysics and Medicine, Saratov Fall Meeting '99, Saratov, Russia, SPIE Proc., In press.

21. Orgill, D.P. and So, P.T.C., "Two-photon confocal microscopy in wound healing," Multiphoton microscopy in the biomedical sciences, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

22. Ragan, T., So, P.T.C., Belmont, A.S., and Gratton, E., "Three-dimensional particle tracking on the two-photon microscope: an investigation of chromosomal dynamics," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

23. So, P.T.C., "Ultrahigh-resolution imaging of biological systems based on standing wave total internal reflection microscopy," Functional Imaging and Optical Manipulation of Living Cells, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

24. Sutin, J.D., Dong, C.Y., Huang, H., Shin, J., Mahadevan, L., Gratton, E., and So, P.T.C., "Magnetic micromanipulation microscopy for single molecule applications," Biomedical Instrumentation Based on Micro- and Nanotechnology, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

25. Yu, B, Dong, C.Y., So, P.T.C., Blankenstein, D., and Langer, R., "Two-Photon Fluorescence Scanning Microscopy of Transdermal Transport Processes," Perspectives in Percutaneous Penetration, 7B', In press.

26. Yu, B., Dong, C.Y., So, P.T.C., Blankschtein, D., and Langer, R., "Application of two-photon microscopy to elucidate oleic acid-induced changes in microscale transdermal transport processes," Multiphoton microscopy in the biomedical sciences, at Biomedical Optics 2001, San Jose, CA, SPIE Proc., In press.

1. Shyamsunder, E., So, P.T C., Tate, M.W., Turner, D.C., and Gruner, S.M., "Cubic Phase in DOPE," Biophys. J. 53, 211a (1988).

2. So, P.T.C., Tate, M.W., Gruner, S.M., and Shyamsunder, E., "X-ray Diffraction Studies on the Effect of Alkanols on DOPE Membrane Under High Pressure," Biophys. J. 57, 274a (1990).

3. So, P.T.C., Potters, M., and Shyamsunder, E., "Determination of the Excess Point in Non-bilayer Lipid Water Membrane Using Optical Scattering," Biophys. J. 59, 504a (1991).

4. So, P.T.C., and Shyamsunder, E., "High Pressure Dilatometric Studies on the Effect of Alkanols on DOPE Membrane Under High Pressure," Biophys. J. 61, 2145a (1992).

5. Dong, C., So, P.T.C., and Gratton, E., "Measurements of Fluorescence Lifetimes and Anisotropies by One-photon and Two-photon Excitation," Biophys. J. 64, 53a (1993).

6. French, T., So, P.T.C., Berland, K.M., and Gratton, E.A., "Time-resolved Fluorescence Microscope," Biophys. J. 64, 110a (1993).

7. So, P.T.C., Dong, C., Berland, K.M., Gratton, E., "Fluorescence Correlation Spectroscopy Utilizing Two-photon Excitation," Biophys. J. 64, 218a (1993).

8. Fishkin, J.B., So, P.T.C., and Gratton, E., "Breakdown of the Diffusion Approximation in Describing Photon Migration Through Random Media," Biophys. J. 64, 222a (1993).

9. Kriechbaum, M., Osterberg, F., Tate, M.W., Shyamsunder, E., Polcyn, A.P., So, P.T.C., Gruner, S.M., and Skita, V., "Time-resolved Pressure Jump Studies on Membrane Lipid by Synchrotron X-ray Diffraction," Biophys. J. 64, 296a (1993).

10. So, P.T.C., Dong, C.Y., Berland, K.M., French, T. and Gratton, E., "A Two-photon Confocal Lifetime Microscopy," Biophys. J. 66, 276a, (1994).

11. Fishkin, J.B., So, P.T.C., Cerussi, A.E., Fantini, S., Franceschini, M.A., "A Frequency-domain Measurement of Spectral Properties of a Multiple Scattering Medium Containing Methemoglobin," Biophys. J., 66, 378a, (1994).

12. French, T., So, P.T C., and Gratton, E., "Fluorescence Photobleaching Effects in a Fluorescence Lifetime Resolved Microscope," Biophys. J., 66, 276a, (1994).

13. Sutin, J.D.B., So, P.T.C., French, T. and Gratton E., "Development of an Optical Low Coherence Reflectometry Microscope for Three-dimensional Imaging of Internal Structures of Biological Systems," Biophys. J., 66, 277a, (1994).

14. Berland, K., So, P.T.C., Dong, C.Y., and Gratton, E., "Cellular Diffusion Studies with Two-photon Fluctuation Correlation Spectroscopy," Biophys. J., 66, 278a, (1994).

15. Berland, K., So, P.T.C., Mantulin, W.W., and Gratton, E., "Molecular Aggregation Studies using Scanning Two-photon Fluctuation Correlation Spectroscopy," Biophys. J., 68,187a (1995).

16. Dong, C.Y., So, P.T.C., and Gratton, E., "Multiphoton Pump-probe Fluorescence Spectroscopy by Stimulated Emission Following Excitation," Biophys. J., 68, 197a, (1995).

17. French, T., So, P.T.C., Berland, K., and Gratton, E., "Oxygen Concentration in Living Cells," Biophys. J., 68, 292a (1995).

18. So, P.T.C., Dong, C.Y., and Gratton, E., "Pump-probe Fluorescence Microscopy by Stimulated Emission Following Excitation," Biophys. J., 68, 289a (1995).

19. Sutin, J.D.B., So, P.T.C., and Gratton, E., "Studies of Conformational Substates in Glasses with Fluorescence Distribution of Lifetimes," Biophys. J., 68, 192a (1995).

20. Yu, W.M., So, P.T.C., French, T. and Gratton E., "Lipid Domains in Biological Membranes Studies by Using a Two-photon Microscope," Biophys. J., 68, 197a (1995).

21. So, P.T C., French, T., Yu, W., Berland, K.M., Dong, C.Y., and Gratton E., "Two-photon Fluorescence Microscopy: Time-resolved and Intensity Imaging," Fluorescence Spectroscopy and Fluorescence Imaging, (B. Herman and X. F. Wang, Ed), John Wiley & Sons, (1996).

22. Berland, K., So, P.T.C., Ragan, T., Yu, W. and Gratton, E., "Two-photon Excitation for Low Background Fluorescence Microscopy: Detection of Single Molecules and Single Chromophores in Solution," Biophys. J., 70, 429a (1996).

23. Chen Y., Berland, K., So, P.T.C., Mantulin, W.W., and Gratton, E., "Study of Protein Aggregation in Solution Using Scanning Two-photon Fluorescence High Order Correlation Spectroscopy," Biophys. J., 70, 429a (1996).

24. Dong, C.Y., So, P.T.C., and Gratton, E., "Pump-probe Fluorescence Microscopy: A New Method For Time-resolved Imaging With High Spatial Resolution," Biophys. J., 70, 427a (1996).

25. French, T., So, P.T.C., Gratton, E., Carrero, J., and Voss, E.W. Jr., "Fluorescence Antigen Processing by Macrophages," Biophys. J., 70, 426a (1996).

26. Fulmer, T., So, P.T.C., Glaser, M., Mantulin, W.W., "Low Temperature Time-resolved and Steady-state Fluorescence Spectroscopy Studies of Five Single Tryptophan Mutants of E. Coli Adenylate Kinase," Biophys. J., 70, 301a (1996).

27. Ragan, T., Berland, K.M., So, P.T.C., Yu, M., and Gratton, E., "Imaging a Single Fluorophore using Two-photon Excitation," Biophys. J., 70, 429a (1996).

28. So, P.T.C., Ragan, T., Yu, W., and Gratton, E., "Two-photon 3-D Single Particle Tracking: A Scanning Microscopy Approach," Biophys. J., 70, 395a (1996).

29. Yu, W., So, P.T.C., French, T., Mantulin, W.W., and Gratton, E., "Kinetic Imaging of A Single Molecule," Biophys. J., 70, 197a (1996).

30. French, T., So, P.T.C., Dong, C.Y., Berland, K.M., and Gratton, E., "Fluorescence Lifetime Imaging Techniques For Microscopy.," Methods in Cell Biology (G. Sluder and D.E. Wolf, ed.), Academic Press, (1997).

31. Chen, Y., So, P.T.C., and Gratton, E., "Study of Molecular Aggregation by Analysis of Photon Distribution of Single Molecules," Biophys. J., 72, 213a (1997).

32. Dong, C.Y., Buehler, C., So, P.T.C., and Gratton, E., "Frequency Domain Pump-probe Stimulated Emission Spectroscopy Using a Fluorescence Microscope," Biophys. J., 72, 211a (1997).

33. Dong, C.Y., So, P.T.C., and Gratton, E., "Pump-probe Stimulated Emission Microscopy," Biophys. J., 72, 218a (1997).

34. Masters, B.R., So, P.T.C., and Gratton, E., Multi-photon Excitation Fluorescence Microscopy and Spectroscopy of In Vivo Human Skin," Biophys. J., 72, 214a (1997).

35. Ragan, T., So, P.T.C., and Gratton, E., "Two-photon 3-D Particle Tracking in Cells," Biophys. J., 72, 214a (1997).

36. So, P.T.C., "Two-photon 3-D Particle Manipulation: An Application of Brownian Ratchet," Biophys. J., 72, 218a (1997).

37. So, P.T.C., Dong, C.Y., Berland, K.M., French, T. and Gratton, E., "Time-resolved Stimulated-emission and Absorption Microscopy," Topics in Fluorescence V, (J. Lackowicz, Ed.), Plenum Press, (1998).

38. Buehler, C., Dong, C.Y., So, P.T.C., and Gratton, E., "Multi-photon, Multi-wavelength, Pump-Probe Spectroscopy," Biophys. J., 74, 182a (1998).

39. Cragg, G.E. and So, P.T.C., "Effecting Cellular Cytoskeletal Changes Using A Magnetic Trap," Biophys. J., 74, 183a (1998).

40. Dong, C.Y., Buehler, C., So, P.T.C., and Gratton, E., "Two-photon Time-resolved Polarization Imaging Inside Mouse Fibroblast Cells," Biophys. J., 74, 188a (1998).

41. Duggar, K.H., Lauffenburger, D.A., and So, P.T.C., "Two-photon Single Particle Tracking Studies of Integrin-Fibronectin Mediated Phagocytosis," Biophys. J., 74, 184a (1998).

42. Masters, B.R., Mantulin, M.M., Gratton, E., and So, P.T.C., "Simultaneous Two-Photon Fluorescence and Reflected Light Confocal Imaging of In Vivo Human Skin," Biophys. J., 74, 185a (1998).

43. Ragan, T., So, P.T.C., and Gratton, E., "3-D Particle Tracking Using Two-photon Excitation: Probing The Cytoplasmic Structure," Biophys. J., 74, 183a (1998).

44. Masters, B.R., So, P.T.C., and Gratton, E., "Multi-photon Excitation Microscopy and Spectroscopy of Cells, Tissues and Human Skin In Vivo," Fluorescent and Luminescent Probes, (Mason, Ed.), Academic Press, (1999).

45. Buehler, C, Kim., K.H. and So, P.T.C., "Direct View Two-photon Microscopy," Biophys. J., 76, 98a (1999).

46. Cragg, G., Huang, H., Dong, C. Y., Lee, R.T., Kamm, R. D., Lauffenburger, D. A., So, P.T.C., "Applications of Magnetic and Optical Micro-manipulators to Signal Transduction in Cells," Biophys. J., 76, 94a (1999).

47. Dong, C.Y, So, P.T.C., Mahadevan, L., Kaizuka, Y., Sutin, J. D., Gratton, E., "Control of Exonuclease Digestion Activities by Microscopic Mechanical Forces," Biophys. J., 76, 132a (1999).**

48. Duggar, K.H., Lauffenburger, D.A., So, P.T.C., "Two-photon Fluorescence Resonance Energy Transfer and Its Application to Protein Bond Counting," Biophys. J., 76, 98a (1999).

49. Frolov, A., So, P.T.C., Petrescu, A., Gratton, E., and Schroeder, F., "Multi-photon Excitation Imaging of Naturally Occurring Fluorescent Sterol(dehydroergosterol) in Intact Cells," Biophys. J., 76, 99a (1999).

50. Gilbert, R. J., Napadow, V.J., Buehler, C, and So, P.T.C., "Three-dimensionally Resolved Deep Tissue Imaging of Skeletal Muscle from the Bovine Tongue using Two-photon Microscopy," Biophys. J., 76, 97a (1999).

51. Hsu, L., So, P.T.C., Dong, C.Y., "Improving Two-photon Deep Tissue Image with Blind Maximum-likelihood Deconvolution," Biophys. J., 76, 98a (1999).

52. Kim, H.K., Buehler, C, So, P T C., "High-Speed, Two-photon Scanning Microscopy," Biophys. J., 76, 99a (1999).

53. Kwon, H.S., Dong, C.Y., So, P.T.C., "Incorporating Point Spread Function Aberration Information In Two-photon 3D Single Particle Tracking," Biophys. J., 76, 98a (1999).

54. So, P.T.C., Dong, C.Y., Kaizuka, Y., "Micro-manipulation of Actin-myosin Complex by Two-photon Uncaging of ATP Molecules," Biophys. J., 76, 98a (1999).

55. Berland, K.M. and So, P.T.C., "Dual-color fluorescence correlation spectroscopy using two-photon excitation," Biophys. J., 78, 441a (2000).

56. Buhler, C., Auer, M., So, P.T.C., Dong, C., Mueller, K., Schilb, A., Hassiepen, U., Stoeckli, K., and Dressen, J., "Multi-photon excitation of intrinsic protein fluroescence has the potential to dramatically improve pharmaceutical drug screening," Biophys. J., 78, 256a (2000).

57. Capitano, A.T., Dong, C.Y., Powers, M.J., Baker, C.S., Griffith, L.G., and So, P.T.C., "Characterization of a vacularized hepatic tissue bioreactor using 2-photon microscopy," Biophys. J., 78, 254a (2000).

58. Cragg, G. and So, P.T.C., "Standing Wave Total Internal Reflection Microscopy - Breaking the Diffraction Resolution Limit," Biophys. J., 78, 248a (2000).

59. Dong, C.Y., Kwon, H.K., Kim, G., Huang. H., Cragg, G., Sutin, J., Gratton, E., and So, P.T.C., "Design of a magnetic manipulation microscope and its application to torsional-dependent DNA binding kinetics," Biophys. J., 78, 446a (2000).

60. Hsu, L., Berland, K.M., Kaplan, P., Dong, C.Y., So, P.T.C., "Excitation wavelength resolved two-photon imaging of human skin structures," Biophys. J., 78, 444a (2000).

61. Huang, H., Zhang, X., Kwon, H-S, Kamm, R.D., Gilbert, R., Lee, R., So, P.T.C., "Effect of mechanical stresses on cellular GFP-actin distribution," Biophys. J., 78, 368a (2000).

62. Kim, K.H., Buehler, C., Engleward, B.P., and So, P.T.C., "The design of an automated video rate two-photon microscope for mutation detection in tissues," Biophys. J., 78, 445a (2000).

63. Kwon H-S, Dong, C.Y., and So, P.T.C., "Two-photon single particle tracking - a new tool to study cytoskeleton dynamics during cell migration," Biophys. J., 78, 444a (2000).

64. Napadow, V.J., Dong, C.Y., Chen, Q., So, P.T.C., Gilbert, R.J., "Three-dimensional autocorrelation algorithm for deriving fiber orientation from deep tissue two-photon microscopy imaging," Biophys. J., 78, 444a (2000).

65. So, P.T.C., Dong, C.Y., Bevin, E. and Koenig, K., "Quantification of two-photon point spread function degradation in turbid medium," Biophys. J., 78, 444a (2000).

66. Sutin, J.B., Dong, C. Y. So, P.T.C., Mahadevan, L. and Gratton, E., "Magnetic micromanipulation of single molecules of exonuclease during DNA degradation," Biophys. J., 78, 304a (2000).

67. Dong, C.Y., Kim, K.H., Buehler, C., Hsu, L., Kim, H., Masters, B.R., Gratton, E., Kochevar, I.E., and So, P.T.C., "Probing Deep-tissue Structures by Two-photon Fluorescence Microscopy," Emerging Tools for Single Cell Analysis: Advances in Optical Measurement Technologies, (G. Durack and P. Robinson, Eds.), Wily-Liss, 2000.

68. Buehler, Ch., Dreessen, J., Mueller, K., So, P.T.C., Dong, C.Y., Schilb, A., Hassiepen, U., Stoeckli, K., and M. Auer, "Multi-Photon Excitation of Intrinsic Protein Fluorescence and its Application to Pharmaceutical Drug Screening", P.N.A.S., Submitted.

69. Dong, C.Y., Koenig, K., So, P.T.C., "Characterizing Point-Spread-Functions of Two-Photon Fluorescence Microscopy in Turbid Medium", J. Micro., Submitted.

70. Napdow, V., Chen, Q., Mai, V., So, P.T.C., and Gilbert, R.J., "Quantitative Analysis of Fiber Architecture in Heterogeneous Skeletal Muscle Using MRI and Optical Methods," Biophys. J., Submitted.

71. So, P.T.C., Kwon, H.S., and Dong, C.Y., "Resolution Enhancement in Standing-Wave Total Internal Reflection Microscopy: A Point Spread Function Engineering Approach," Opt. Soc. of Am. A., Submitted.

72. So, P.T.C., Kim, K.H., Buehler, C., Masters, B.R., Hsu, L. and Dong, C. Y., "Basic Principles of Multiphoton Excitation," Methods in Cellular Imaging (A. Periasamy Ed.), In press.

73. Sutin, J., So, P.T.C., Fulmer, T., Mantulin, W.W., and Gratton, E., "A Low Temperature Sample Chamber For Frequency Domain Time-resolved Fluorescence Spectroscopy," Review of Scientific Instruments, Submitted.

74. Yu, B., Dong, C.Y., So, P.T.C., Blankstein, D., and Langer, R., "Two-Photon Scanning Fluorescence Imaging of Transdermal Transport Processes," J. Invest. Dermat., Submitted.

Patents

T. Ragan, K. H. Kim, L. Laiho, H. Huang, P. T. C. So"Two-Photon 3-D Image Cytometery," pending

G. Cragg, C.Y. Dong, H.S. Kwong, and P.T.C. So, "Standing Wave Total Internal Reflection Microscopy (SWTIR),US Patent No. 6,255,642 , July 3, 2001

C.Y. Dong, E. Gratton, and P.T.C. So, "Time-Resolved Pump-Probe Fluorescence Microscopy", US Patent No. 5,814,820 , Sept. 29, 1998

Doctoral Theses

Hayden Huang, "Cellular Responses to Mechanical Stresses Applied via Magnetic Manipulators", 2001.

Tae-Woong Koo, "Measurement of Analytes Through Turbid Media by Raman Spectroscopy", 2001.

Ki Hean Kim, "Two-Photon Video Rate Microscopy for Non-invasive Biopsy" (current)

Lily Hsu, "New Microscopy Techniques for Tissue Engineering - Functional Diagnostic and Substrate Lithographic Modification" (current)

Hyuk Sang Kwon, "Two-photon Single Particle Tracking - A Study of Intracellular Transport Processes" (current)

Euiheon Chung, "Super-Diffraction Limited Imaging Using Standing Wave Total Internal Reflection Microscopy" (current)

Maxine Jonas, "Fast Fluorescence Microrheometry for Quantitative Study of Cytoskeletal Mechanotransduction" (current)

Tsu-Te Judith Su, "Lithographic Regulation of Cellular Mechanical Properties", 2004

Tuck Meng Lui, "Wavelet-Based Multi-Resolution Techniques for Two Dimensional Data Analysis", 1999 (Dept. of Civil Engineering)

George Cragg, "Ultra-High Resolution Optical Imaging by Standing Wave Total Internal Reflection Microscopy", 2000

Costas M. Pitsillides, "Selective Cell Targeting with Light-Absorbing Particles", 2000

Tsu-Te Judith Su, "Phloem Transport in Arabidopsis Thaliana Seedlings as a Function of Osmotic Stress", 2002

Lawrence Chow, "A Monte Carlo Study of Two-photon Point Spread Function in Turbid Medium", 1997

Alankar Chhabra, "Man-Portable, Rocket-Propelled Surveillance Vehicle", 1998

Eric A. Bevin, "Two-Color Imaging to Determine Two-Photon Microscopy Point Spread Function in Turbid Media", 1999

Bill J. Simmons, "Identification of Non-inhibiting Stains for Lambda Exonuclease Digestion of Lambda DNA", 1999

William H. III Stadtlander, "Improving Two-photon Tissue Imaging Resolution Based on Maximum Likelihood Blind Deconvolution", 1999

Adam E. Weintraub, "Redesign of Anchoring and Location Mechanism of the Coaxial Breast Biopsy System", 1999

Sneha Madhavan, "A Magnetic DNA Twisting Device", 2000

Seth O. Newburg, "A feasibility Study of Lambda-Exonuclease Step Size Measurement at the Angstrom Sacle", 2000