Current Research in Biological Optical Microscopy
NSF DBI-9987122 (PI) 9/15/2000-9/14/2003
Wave Total Internal Reflection Microscopy - in vivo biological
imaging at the nanometer scale"
The goal of this project is to develop an optical imaging technique
that can image biological systems with resolution better than 50 nm.
NIH/NCI R21/R33 CA84740-01 (co-PI) 9/15/2000-9/14/2004
"Fluorescence Detection of Genetic Instability in Mice"
The goal of this project is to develop a methodology to study cancinogenesis
resulting from recombination events inside in vivo tissues.
NIH/HLBI P01 HL64858-01A1 (co-PI) 9/28/2001-9/17/2006
"Mechanotransduction in Cardiovascular Cells"
The goal of this project is to understand mechanotransduction processes
in cardiovascular cells.
NIH/NCI R33 CA091354-01A1 (PI) 5/1/2002-4/30/2005
"Two-Photon Optical Biopsy Probe"
The goal of this project is to develop a hand-held two-photon microscopic
biopsy probe for a minimally invasive detection of cancer.
and Current Student Degree Theses
Huang, "A Measurement of Smooth Muscle Cells' Gene Activation Under
Precision Controlled Mechanical Stress and Strain", 2001
Tae-Woong Koo, "Measurement of Analytes Through Turbid Media by Raman
Ki Hean Kim, "Two-Photon Video Rate Microscopy for Non-invasive Biopsy"
Lily Hsu, "New Microscopy Techniques for Tissue Engineering - Functional
Diagnostic and Substrate Lithographic Modification" (current)
Hyuk Sang Kwon, "Two-Photon Single Particle Tracking - A Study of
Intracellular Transport Processes" (current)
Euiheon Chung, "Super-Diffraction Limited Imaging Using Standing
Wave Total Internal Reflection Microscopy" (current)
Maxine Jonas, "High Bandwidth, High Specificity Microrheometry"
Meng Lui, "Wavelet-Based Multi-Resolution Techniques for Two Dimensional
Data Analysis", 1999 (Dept. of Civil Engineering)
George Cragg, "Ultra-High Resolution Optical Imaging by Standing
Wave Total Internal Reflection Microscopy", 2000
Costas M. Pitsillides, "Selective Cell Targeting with Light-Absorbing
Chow, "A Monte Carlo Study of Two-Photon Point Spread Function in
Turbid Medium", 1997
Alankar Chhabra, "Man-Portable, Rocket-Propelled Surveillance Vehicle",
Eric A. Bevin, "Two-Color Imaging to Determine Two-Photon Microscopy
Point Spread Function in Turbid Media", 1999
Bill J. Simmons, "Identification of Non-inhibiting Stains for Lambda
Exonuclease Digestion of Lambda DNA", 1999
William H. III Stadtlander, "Improving Two-Photon Tissue Imaging
Resolution Based on Maximum Likelihood Blind Deconvolution", 1999
Adam E. Weintraub, "Redesign of Anchoring and Location Mechanism
of the Coaxial Breast Biopsy System", 1999
Sneha Madhavan, "A Magnetic DNA Twisting Device", 2000
Seth O. Newburg, "A Feasibility Study of Lambda-Exonuclease Step
Size Measurement at the Angstrom Sacle", 2000