Unless you are following a style guide that specifies otherwise, observe the following conventions.
Use acronyms to shorten phrases in order to save space or to avoid awkward repetition of phrases. Acronyms are abbreviations of the things they represent and are formed by combining the first, and sometimes other, letters of the principal words.
AIDS
Acquired Immunodeficiency Syndrome
RAM
random-access memory
ROM
read-only memory
DOS
Disk Operating System
FTP
file transfer protocol
HTML
Hypertext Markup Language
HIV
Human Immunodeficiency Virus
Hypertext Markup Language (HTML) was never
intended to be a common programming language. The original
assumption was that most word processing applications would
automatically generate HTML code.
This convention is necessary to avoid ambiguity. NMR, for example, may refer to nuclear magnetic resonance or to the National Maritime Repository.
The number of MDs in the region has declined.