Brain Interface: Neural Recording and Fiberless Optical Neuromodulation at Cellular Resolution

4th November 2020

Timing : 1 pm EST

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In this talk, I will review the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface including optogenetics. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously. In order to obtain optical stimulation capability, we monolithically integrated optical waveguides on the silicon substrate to bring light to the probe shank tips. We could successfully validate excitation and inhibition of neural activities by switching the wavelengths delivered to the distal end of the waveguide. For scaling of the number of stimulation sites, we directly integrated multiple micro-LEDs on the probe shank to achieve high spatial temporal modulation of neural circuits. We demonstrated independent control of distinct cells ~50 μm apart and of differential somato-dendritic compartments of single neurons in the CA1 pyramidal layer of anesthetized and freely-moving mice.

Euisik Yoon
Professor, Dept. of Electrical Engineering and Computer Science
Professor, Dept. of Biomedical Engineering
Director, NSF International Program for Advancement of Neurotechnology
University of Michigan
Ann Arbor, MI 48109-2122

Euisik Yoon received the B.S. and M.S. degrees in electronics engineering from Seoul National University in 1982 and 1984, respectively, and the Ph.D. degree in electrical engineering from the University of Michigan, Ann Arbor, in 1990.
He worked for industry including the National Semiconductor Corp. in Santa Clara, CA and Silicon Graphics Inc. in Mountain View, CA before returning to academia. He took faculty positions in the Department of Electrical Engineering at Korea Advanced Institute of Science and Technology (KAIST) in Daejon, Korea and in the Department of Electrical and Computer Engineering at the University of Minnesota, Minneapolis, MN, respectively. During the academic year of 2000-2001, he was a Visiting Faculty at Agilent Laboratory, Palo Alto, CA. In 2008, he joined the Department of Electrical Engineering and Computer Science at the University of Michigan, Ann Arbor, MI, where he is a Professor and the Director of NSF International Program for the Advancement of Neurotechnology (IPAN). He served as the Director of Solid-State Electronics Laboratory (2011-2015) and the Director of Lurie Nanofabrication Facility (2011-2016) at the University of Michigan. He is the co-founder of NeuroLight Technologies.
Dr. Yoon has served on various Technical Program Committees including the International Sensor Conference, the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), the IEEE International Electron Device Meeting (IEDM) and the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). He also served on the IEEE International Solid-State Circuit Conference (ISSCC) program committee and organized and co-chaired the International Conference for Advanced Neurotechnology (ICAN).