Nolan Lab

Chemistry & Biology of the Host–pathogen Interaction


Last updated 05/03/19

Group Photo.... March 13, 2019

Welcome to the Nolan Lab!

We are members of the Department of Chemistry at MIT. We are fascinated by the chemistry and biology of the host–pathogen interaction and the competition for nutrients that occurs during microbial infection. We examine host-defense peptides and proteins that contribute to human innate immunity, and how these factors impact microbial physiology. We also investigate bacterial secondary metabolites and proteins that contribute to virulence. In a related area, we consider non-traditional approaches to combating bacterial infection. Our projects address the chemistry and biology of transition metal ions that are essential nutrients and how the host and pathogen compete for these resources. Our experimental approach is problem-based and hypothesis-driven. We use the concepts and toolkits of chemistry, biochemistry, microbiology, and cell biology to bring molecular understanding to fundamental questions at the chemistry/biology/medicine interface.