04/04/24 : Rachel presents a poster on her siderophore conjugate studies at the MIT-Merck Symposium!
04/01/24 : We welcome Ines Herceg, a master’s student from ETH Zurich, to the group!
03/04/24 : We are delighted that our first collaborative paper on using enterobactin for radioactive Ti(IV) imaging with the Boros Lab at University of Wisconsin is accepted for publication at Angew. Chem. Int. Ed. – congrats Angus, Owen, Molly, Rachel and Edith!
02/19/24 : Our story of designing and evaluating enterobactin-drug conjugates that target Gram-negative bacterial pathogens is accepted for publication in Accounts of Chemical Research – congratulations Chuchu!
02/13/24 : Our manuscript on beta-lactam antibiotic delivery by native and non-native triscatecholate siderophores is accepted for publication in Journal of the American Chemical Society – congratulations Rachel, Chuchu, Artur, Gregory and Martina!
02/05/24 : Our manuscript on enterobactin-mediated delivery of Pt(IV) prodrugs and their cellular consequences is accepted for publication at ACS Infectious Diseases – congratulations Chuchu and Abraham!
12/21/23 : Our manuscript describing iron withholding by murine calprotectin is accepted for publication in ACS Infect. Dis. - congrats Janet and Angelica!
12/14/23 : Welcome to our new first-year chemistry student, Erica Debley!
10/30/23 : Our collaborative paper with the Brunold Lab on Co(II) binding to human calprotectin is accepted for publication in J. Biol. Inorg. Chem. - congrats Mickie and Megan!
10/20/23 : Chuchu departs for her new position as an analytical chemist at Amgen, best of luck Chuchu!
10/19/23: Lab lunch at Mulan!
10/18/23: Belated September birthday celebration!
10/05/23 : Rachel and Wei Hao attend the 12th Annual Boston Symposium on Organic and Bioorganic Chemistry!
07/30/23 : Liz and Mayukh follow to join the Cell Biology of Metals GRC!
07/28/23 : Janet and Rachel head to the Cell Biology of Metals GRS and GRC!
07/24/23 : Chuchu defends her thesis – congratulations Dr. Guo!
06/12/23 : Janet presents a poster on murine calprotectin at the 2023 Boston Bacterial Meeting!
05/25/23 : Janet gives an oral presentation on murine calprotectin at the MIT-Merck symposium!
05/16/23 : Angelica receives the Outstanding UROP Presentation Award in recognition of the best undergraduate research presentation at the Chemistry UROP Symposium – congratulations, Angelica!
03/29/23 : Congratulations to Rachel and our former lab member Adun for being awarded NSF Graduate Research Fellowships!
02/01/23 : We welcome Bellen Wong, a junior studying Biochemistry and Computer Science at Wellesley College! Bellen will be working in the S100 subgroup.
01/21/23 : Janet and Mayukh attend the BRIC at Yale and Janet presents a poster on her S100 research!
01/19/23 : Our review covering post-transcriptional modifications on calprotectin is accepted for publication in BioMetals - congrats, Janet!
12/12/22 : Janet receives a 2022 Mentorship Spotlight Award – congratulations, Janet!
11/17/22 : Janet presents her research on S100 proteins at the WIC+ / CADI Poster Symposium!
11/17/22 : Welcome to our new first-year chemistry student, Ghazal Kamyabi!
11/14/22 : Congratulations to our former UROP Jupneet Singh on being awarded a Rhodes Scholarship!
10/13/22 : Chuchu and Abraham present at the Boston Symposium on Organic and Bioorganic Chemistry!
09/20/22 : Welcome to Celis Lee, currently a Junior studying Chemistry at Wellesley College! Celis will be working in the S100 subgroup.
09/13/22 : Our collaborative study with the Raffatellu Lab at UCSD on siderophore-based immunization against adhesive-invasive Escherichia coli is published in mBio!
08/07/22 : Our manuscript investigating the enterobactin-directed delivery of Pt(IV) prodrugs is accepted for publication in the Journal of the American Chemical Society ! Congratulations Chuchu!
05/26/22 : It is commencement and we're welcoming Emily and Adun back for the celebrations, congratulations!
05/08/22 : Our manuscript on the interplay between S100A12, bacterial metal transport machinery and Zn(II) is accepted for publication in a special issue of the Journal of Inorganic Biochemistry on Metal Trafficking in Infection of Immunity – congrats Tomer!
05/05/22 : We welcome two new UROPS, Angelica Phan and Jaden Anderson, who will be joining the lab this summer!
02/16/22 : Farewell to Tomer - we'll miss you, best wishes for your new position at AbbVie!
01/24/22 : Our Trends in Microbiology review article on metal sequestration by S100 proteins in chemically diverse environments is published online – congrats Tomer and Abraham!
01/07/22 : Our manuscript on the interplay between calprotectin, the bacterial solute-binding proteins streptococcal PsaA and staphylococcal MntC, and Zn(II) is accepted for publication at Metallomics – congrats Tomer, Rose, Aaron and Daniel! This work is in collaboration with the Shearer lab at Trinity University.
11/15/21 : A very warm welcome to our new first-year chemistry student, Rachel Motz!
11/04/21 : Chuchu presents a virtual poster on her research at the Boston Symposium on Organic and Bioorganic Chemistry!
10/16/21 : Chuchu is off to the Cell Biology of Metals GRS and GRC and will present her work on siderophore conjugates!
10/13/21 : Our perspective on bacterial responses to iron withholding by calprotectin is accepted for publication in Biochemistry – congrats Adun and Emily!
09/14/21 : Our collaborative manuscript with Profs. Griffin and Silvers on solution NMR studies of calprotectin is accepted for publication at J. Am. Chem. Soc. – congrats Robert and Jules!
09/01/21 : Welcome first-year chemistry graduate students!
08/31/21 : Farewell to Emily – we’ll miss you, best wishes at Novartis!
08/09/21 : Farewell to Artur – we’ll miss you, best wishes at your new position at HMS!
07/27/21 : Emily defends her thesis today – congratulations, Dr. Zygiel!
07/23/21 : Our manuscript detailing a collaborative proteomics study with the Oglesby and Kane Labs on the effect of calprotectin on Pseudomonas aeruginosa is accepted for publication in Microbiol. Spectr. – congrats Cassie, Weiliang, and Emily!
02/22/21 : Our manuscript on siderophore-β-lactam conjugate delivery to Salmonella is accepted for publication in ACS Infect. Dis. – congrats Artur, Martina, and Tengfei! This paper will be part of a special issue on gut microbes.
02/12/21 : First-year chemistry student Wei Hao Lee joins the lab – welcome Wei Hao!
01/04/21 : Mayukh Bhadra joins us for his post-doc – welcome Mayukh!
12/31/20 : Our manuscript on siderophore-β-lactam conjugate delivery to uropathogenic E. coli is accepted for publication in Chem. Sci. – congrats Artur, Tim, and Hiu!
12/03/20 : Our manuscript reporting how heme affects the response of Pseudomonas aeruginosa and Staphylococcus aureus to calprotectin is accepted for publication in J. Biol. Chem. – congrats Emily, Adun and Cassie!
07/14/20 : Our review on harnessing iron uptake machinery to target enteric bacteria is accepted for publication in Journal of Infectious Disease - congrats Artur and Romana! This review will be published in a special supplement entitled “The State of Microbiome Science at the Intersection of Infectious Disease and Antimicrobial Resistance.”
06/30/20 : Our manuscript on how mildly acidic pH affects the metal-binding and antimicrobial properties of human calprotectin is accepted for publication in Biochemistry – congrats, Tomer!
06/26/20 : Our manuscript in collaboration with the Gross Lab at Washington University describing an integrated mass spectrometry study of Ca(II) binding by calprotectin is accepted for publication in J. Am. Chem. Soc. – congrats Jagat and Jules!
10/15/19: Artur, Emily and Chuchu attend the BSOBC 2019 conference!
07/01/19: Lab lunch at Mulan!
06/06/19 : Congratulations to Lisa and Rose on their graduation! Here are our recent graduates with Liz!
05/30/19: Farewell to Rose! Good luck on your future endeavors!
05/21/19 : Our collaborative manuscript with the Britt lab at UC Davis and Dr. Andrew Ozarowski at the NMHFL on high-field EPR spectroscopic evaluation of two bacterial solute-binding proteins that capture Mn(II) is accepted for publication in J. Phys. Chem. B - congrats Derek and Rose!
05/03/19 : Our manuscript describing the Mn(II)-binding properties of murine calprotectin is accepted for publication in Inorganic Chemistry- congrats Rose and Derek! This work extended our EPR spectroscopic collaboration with the Britt lab at UC Davis and includes high-field EPR spectra of Mn(II)-bound CP collected by Rose at the NHMFL.
04/08/19 : Emily is awarded a Whitaker Health Sciences Fund Fellowship congratulations, Emily!
03/27/19 : Lab dinner at Sumiao Hunan Kitchen celebrating Rose's thesis defense and the close of Alvin's final year project!
03/27/19 : Rose defends her thesis today. Congratulations, Dr. Hadley!
03/13/19 : Group photo day! What's your favorite element?
02/05/19 : Liz is promoted to Professor effective July 1, 2019!
02/01/19 : We welcome Dr. Abraham Wang to the lab! Abraham recently completed his PhD at University of Illinois at Urbana- Champaign where he was a graduate student in Wilfred van der Donk's lab.
01/08/19 : Our collaborative investigation with Prof. Mandy Oglesby-Sherrouse's group at University of Maryland reporting that human calprotectin induces iron starvation responses in the opportunistic human pathogen Pseudomonas aeruginosa is accepted for publication in J. Biol. Chem. - congrats Emily, Cassie, and Luke!
01/05/19 : Welcoming the New Year - lab dinner at Liz's home!
12/18/18 : We are delighted to be awarded MIT-Korea-KAIST Global Seed Funds for collaboration with Prof. Mi Hee Lim's group at KAIST, Korea.
11/29/18 : Lisa defense her thesis today congratulations, Dr. Cunden!
11/14/18 : First-year chemistry student Chuchu Guo joins the lab - welcome Chuchu!
11/08/18 : We are honored to be awarded a 2018 Prof. Amar G. Bose Grant to support our non-traditional antibiotic initiatives - thank you to the selection committee and sponsors!
10/31/18 : Happy Halloween! Farewell to Clementine and pumpkin carving party for Halloween!
10/31/18 : Our manuscript describing how oxidative post-translational modifications affect human calprotectin is accepted for publication in J. Am. Chem. Soc. - congrats Jules, Fangting, and Rebekah!
10/15/18 : We welcome Dr. Pascal Arnoux and Clementine Laffont to MIT! Thank you to the MISTI-France Global Seed Funds program for supporting this exchange.
10/01/18 : We welcome Dr. Aaron Bozzi to the lab! Aaron recently completed his PhD at Harvard University where he was a graduate student in Rachelle Gaudet's lab.
09/06/18 : Emily presents a poster on her recent studies of calprotectin at the Smith Family Foundation Scientific Poster Session at the Harvard Club in Boston, MA!
08/19/18 : Thousands of chemists arrive in Boston for the ACS National Meeting! Rose will be presenting her recent studies of murine calprotectin in the Tuesday afternoon bioinorganic session.
07/03/18 : Our collaborative paper with the Lim Lab at KAIST on the interplay between S100 proteins, the amyloid-beta peptide, and metal ions is accepted for publication in Metallomics - congrats to all members of the team contributing to this Work!
06/28/18 : Our invited protocol on calprotectin and the redox speciation of iron is accepted for publication in a special issue of Methods in Molecular Biology on Ca(II)-binding proteins - congrats, Rose!
06/22/18 : New synthetic work - a study on a reducible disulfide linker for siderophore-antibiotic conjugate design is accepted for publication in J. Biol. Inorg. Chem. - congrats, Wilma! The paper Will be published in a special issue honoring Professor Alison Butler, 2018 Alfred Bader Prize recipient - congrats again, Alison!
06/20/18 : Farewell lunch for Jules and Wilma - we'l miss you both! Jules is now a Scientist at Eagle Pharmaceuticals and Wilma will be starting her new position as a Project Leader at University of Bochum, Germany, in August.
06/11/18 : Another manuscript is accepted today! Our collaborative work with the Drennan lab reporting a new crystal structure of human calprotectin bound to Ni(II) and additional biophysical studies is accepted for publication in Biochemistry - congrats Toshiki, Sarah, and Emily!
06/11/18 : Our invited protocol on psoriasin purification and characterization is accepted for publication in a special issue of Methods in Molecular Biology on Ca(II)-binding proteins - congrats, Lisa!
06/07/18 : The hooding ceremony for doctoral degree recipients is today - congratulations, Jules!
05/31/18 : It is conference season - Wilma and Emily are presenting at the the Boston Bacterial Meeting this week and Rose is off to the Bioinorganic Workshop at Penn State University today!
05/30/18 : Rose receives a WIC travel grant to support her participation in the 2018 Bioinorganic Workshop and Symposium at Penn State!
05/07/18 : Jules defends his Ph.D. thesis today, woohoo - congratulations, Dr. Stephan!
04/27/18 : Rose gives today's Chemistry Student Seminar and presents her work on murine calprotectin!
04/16/18 : Our manuscript describing initial biochemical and functional evaluation of murine calprotectin is accepted for publication in Biochemistry - congrats Rose and Vicky!
04/15/18 : Lisa attends the 14th ASM Conference on Candida and Candidiasis and presents a poster on S100A12!
04/13/18 : From a collaboration with the Imperiali Lab, a manuscript on enterobactin analogs and iron uptake in Camphylobacter jejuni is accepted for publication in Bioorg. Med. Chem. - congrats Cristy, Amael, and Wilma! The paper will be published in a special issue honoring Professor Laura Kiessling, 2017 Tetrahedron Prize recipient congrats again, Laura!
04/15/18 : Lisa attends the 14th ASM Conference on Candida and Candidiasis and presents a poster on S100A12!
04/02/18 : Jules gives today's Biological Chemistry Seminar and presents his work on human calprotectin!
03/26/18 : From our ongoing collaboration with the Raffatellu Lab at UCSD, a manuscript describing cytoplasmic activation of a siderophore-fluoroquinolone conjugate is accepted for publication in J. Am. Chem. Soc. - congrats Wilma and Martina!
02/27/18 : Lisa receives a Dow Travel Grant to attend the ASM Conference on Candida and Candidiasis in April 2018 - congrats, Lisa!
02/09/18 : We welcome two new UROP students, Ravalika Damerla and Adun Obisesan, to the group!
01/30/18 : A perspective on Zn(II) chelation by human S100 proteins is accepted for publication in Biochemistry - congrats, Lisa!
01/16/18 : From a collaboration with the Shoulders and Lippard Labs, a manuscript describing a method to selectively deplete Zn(II) from complex biological media using the innate immune protein S100A12 is accepted for publication in J. Am. Chem. Soc. - congrats Chris and Lisa!
12/07/17 : As part of our local outreach, Emily, Lisa and Rose travel to Framingham state University to discuss graduate studies and research in the chemical sciences with current undergraduate chemistry majors.
12/06/17 : Our manuscript, in collaboration with the Britt Lab at UC Davis, describing observation of Mn(II) transfer from bacterial Mn(II) acquisition proteins to human calprotectin is accepted for publication in J. Am. Chem. Soc. - congrats Rose, Derek, Megan, Toshiki and Vicky!
11/28/17 : Our Annual Reviews of Biochemistry manuscript on transition metal sequestration by calprotectin is accepted for publication - congrats Emily!
10/04/17 : Our manuscript describing the Zn(II)-binding and cysteine redox properties of human S100A7 (psoriasin) is accepted for publication in Biochemistry - congrats Lisa, Megan, Grayson and Hope!
09/28/17 : Our manuscript describing the crystal structures of ferric enterobactin and ferric enantioenterobactin is accepted for publication at J. Am. Chem. Soc. - congrats, Tim!
09/25/17 : Steven Liu joins the group for a UROP welcome, Steven!
08/29/17 : Lisa and Emily are both recognized for their contributions to undergraduate education with a Departmental Award for Outstanding Teaching by a Graduate Student- congratulations!
08/22/17 : Farewell lunch for Irêne! lrêne Will be starting her PhD at the Institute Pasteur this fall - best wishes!
08/12/17 : Summer lab BBQ in Liz's backyard!
08/03/17 : We attend an interdepartmental outreach event co-organized by Emily to assemble LEGO Science kits for K-12 learning!
07/26/17: Summer's here! Nolan lab at the Chemistry department BBQ!
07/23/17 : Wilma and Liz join Lisa and Jules for the Cell Biology of Metals GRC!
07/21/17 : Lisa and Jules go to the Cell Biology of Metals Gordon Research Seminar and will give oral presentations this weekend!
06/15/17 : Lisa and Irène present posters on our siderophore and S100 projects at the 2017 Boston Bacterial Meeting!
06/09/17 : Today is Commencement.. Toshiki and Anmol are back for graduation - congratulations!
06/01/17 : Our manuscript describing Ni(II) sequestration by human calprotectin is accepted for publication in J. Am. Chem. Soc. - congrats Toshiki and Emily!
05/26/17 : Vicky's research stay in our lab ends today with a farewell lunch at A4 we wish you all the best!
05/17/17 : We receive a Charles E. Reed Faculty Initiatives Fund award from the MIT Research Support Committee for studies of host-defense peptides - thank you MIT RSC for this generous research support!
05/15/17 : Our manuscript reporting that human calprotectin modulates the redox speciation of iron is accepted for publication in Metallomics - congrats, Toshiki!
04/19/17 : Emily co-organizes an interdepartmental outreach and social event hosted by MIT Chemistry, MIT BioRefs, Graduate Women of MIT and the Edgerton Center to assemble science kits for K-12 learning!
03/17/17 : Emily is awarded a NSF Graduate Research Fellowship - congratulations, Emily!
03/13/17 : Our Essays in Biochemistry manuscript on how Neisseria exploit human metalloproteins for acquiring nutrient metals is accepted for publication - congrats Wilma and Rose!
03/01/17 : We welcome Irène Pitard to the lab. Irène joins us from ENS de Chimie Rennes for her internship!
02/28/17 : Our Accounts of Chemical Research article on the self-assembling host-defense protein human defensin 6 is accepted for publication congratulations, Phoom!
02/24/17 : Jules gives today's Chemistry Student Seminar!
02/15/17 : Jules receives a Dow Travel Grant to support his travel to the Cell Biology of Metals GRC/GRS this summer!
01/18/17 : Jules is awarded Third Prize for his poster presentation at the CEHS Annual Poster Session - congratulations!
01/09/17 : Liz is honored with a Presidential Early Career Award for Scientists and Engineers (PECASE)!
01/09/17 : We welcome Rebekah Costello to the lab. Rebekah is a first-year undergraduate and joins us for a UROP!
01/02/17 : We welcome Vicky Gu to the lab! Vicky joins us from Tianjin University, China, for her undergraduate thesis research!