Publications

 

Lisa S. Cunden, Megan Brunjes Brophy, Grayson E. Rodriguez, Hope A. Flaxman, and Elizabeth M. Nolan. “Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin),” Biochemistry 2017, Just Accepted.

Timothy C. Johnstone and Elizabeth M. Nolan. “Determination of the Molecular Structure of Ferric Enterobactin and Ferric Enantioenterobactin using Racemic Crystallography,” J. Am. Chem. Soc. 2017, Just Accepted.

Toshiki G. Nakashige, Emily M. Zygiel, Catherine L. Drennan, and Elizabeth M. Nolan. “Nickel Sequestration by the Host-Defense Protein Human Calprotectin,” J. Am. Chem. Soc. 2017, 139, 8828-8836.

Tohiki G. Nakashige and Elizabeth M. Nolan. “Human Calprotectin Affects the Redox Speciation of Iron,” Metallomics 2017, 9, 1086-1095.

Wilma Neumann, Rose C. Hadley, and Elizabeth M. Nolan. “Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc,” Essays Biochem. 2017, 61, 211-223.

Phoom Chairatana and Elizabeth M. Nolan. “Human alpha-Defensin 6: a Small Peptide that Self-Assembles and Protects the Host by Entangling Pathogens,” Acc. Chem. Res. 2017, 50, 960-967.

Wilma Neumann, Anmol Gulati, and Elizabeth M. Nolan. “Metal Homeostasis in Infectious Disease: Recent Advances in Bacterial Metallophores and the Human Metal-Withholding Response,” Curr. Opin. Chem. Biol. 2017, 37, 10-18.

Phoom Chairatana, I-Ling Chiang, and Elizabeth M. Nolan. “Human alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans,” Biochemistry 2017, 56, 1033-1041.

Phoom Chairatana and Elizabeth M. Nolan. “Defensins, Lectins, Mucins and Secretory Immunoglobulin A: Microbe-Binding Biomolecules that Contribute to Mucosal Immunity in the Human Gut,” Crit. Rev. Biochem. Mol. Biol. 2017, 52, 45-56.

Tessa M. Baker, Toshiki G. Nakashige, Elizabeth M. Nolan,* and Michael L. Neidig.* “Magnetic Circular Dichroism Studies of Iron(II) Binding to Human Calprotectin,” Chem. Sci. 2017, 8, 1369-1377 (* denotes co-corresponding author).

Martina Sassone-Corsi,# Phoom Chairatana,# Tengfei Zheng, Araceli Perez-Lopez, Robert A. Edwards, Michael D. George, Elizabeth M. Nolan,* and Manuela Raffatellu.*  “Siderophore-based immunization strategy to inhibit growth of enteric pathogens.” Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 13462-13467 (# denotes co-first author; * denotes co-corresponding author).

Mohammed Shabab, Markus F. F. Arnold, Jon Penterman, Andrew J. Wommack, Hartmut T. Bocker, Paul A. Price, Joel S. Griffitts, Elizabeth M. Nolan,* and Graham C. Walker.* “Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247,” Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 10157-10162 (* denotes co-corresponding author).

Toshiki G. Nakashige, Jules R. Stephan, Lisa S. Cunden, Megan Brunjes Brophy, Brenna C. Keegan, Jason M. Shearer, and Elizabeth M. Nolan. “The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility,” J. Am. Chem. Soc. 2016, 138, 12243-12251.

Elizabeth M. Nolan. “BIOCHEMISTRY: A metal shuttle keeps pathogens well fed,” Science 2016, 352, 1055-1056 (invited perspective).

Lisandro J. Gonzalez, Guillermo Bahr, Toshiki G. Nakashige, Elizabeth M. Nolan, Robert A. Bonomo, and Alejandro J. Vila. “Membrane anchoring stabilizes and favors secretion of New Delhi metallo-beta-lactamase,” Nat. Chem. Biol. 2016, 12, 516-522.

Phoom Chairatana, Hiutung Chu, Patricia A. Castillo, Bo Shen, Charles L. Bevins, and Elizabeth M. Nolan. “Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human alpha-Defensin Peptide,” Chem. Sci. 2016, 7, 1738-1752.

Jules R. Stephan and Elizabeth M. Nolan. “Calcium-induced Tetramerization and Zinc Chelation Shield Human Calprotectin from Degradation by Host and Bacterial Extracellular Proteases,” Chem. Sci. 2016, 7, 1962-1975.

Lisa S. Cunden, Aleth Gaillard, and Elizabeth M. Nolan. “Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12,” Chem. Sci. 2016, 7, 1338-1348.

Toshiki G. Nakashige, Bo Zhang, Carsten Krebs, and Elizabeth M. Nolan. “Human Calprotectin Is an Iron-Sequestering Host-Defense Protein,” Nat. Chem. Biol. 2015, 11, 765-771.

Julie L. H. Madsen, Timothy C. Johnstone, and Elizabeth M. Nolan. “Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus,” J. Am. Chem. Soc. 2015, 137, 9117-9127.

Phoom Chairatana, Tengfei Zheng, and Elizabeth M. Nolan, “Targeting Virulence: Salmochelin Modification Tunes the Antibacterial Activity Spectrum of Beta-Lactams for Pathogen-Selective Killing of Escherichia coli,” Chem. Sci. 2015, 6, 4458-4471.

Tengfei Zheng and Elizabeth M. Nolan, “Evaluation of (Acyloxy)alkyl Ester Linkers for Antibiotic Release from Siderophore-Antibiotic Conjugates,” Bioorg. Med. Chem. Lett. 2015, 25, 4987-4991 (invited contribution for the 25th anniversary edition).

Timothy C. Johnstone and Elizabeth M. Nolan, “Beyond Iron: Non-Classical Functions of Bacterial Siderophores,” Dalton Trans. 2015, 44, 6320-6339.

Megan Brunjes Brophy and Elizabeth M. Nolan, “Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms,” ACS Chem. Biol. 2015,10, 641-651.

Haritha R. Chileveru, Shion A. Lim, Phoom Chairatana, Andrew J. Wommack, I-Ling Chiang, and Elizabeth M. Nolan, “Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5,” Biochemistry 2015, 54, 1767-1777.

Derek M. Gagnon, Megan Brunjes Brophy, Sarah E. J. Bowman, Troy A. Stich, Catherine L. Drennan, R. David Britt, and Elizabeth M. Nolan, “Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis,” J. Am. Chem. Soc. 2015, 137, 3004-3016.

Stephanie E. Woods, Monika R. Leonard, Joshua A. Hayden, Megan Brunjes Brophy, Kara R. Bernert, Brigitte Lavoie, Sureshkumar Muthupalani, Mark T. Wharey, Gary M. Mave, Elizabeth M. Nolan, Martin C. Carey, and James G. Fox, “Impaired Cholecystokinin-Induced Gallbladder Emptying Incriminated in Spontaneous “Black” Pigment Gallstone Formation in Germ-free Swiss Webster Mice,” Am. J. Phys. Gastrointest. Liver Pathol. 2015, 308, G335-G349.

Simone Moser, Haritha R. Chileveru, Jill Tomaras, and Elizabeth M. Nolan, A Bacterial Mutant Library as a Tool to Study the Attack of a Defensin Peptide,” ChemBioChem 2014, 15, 2684-2688.

Andrew J. Wommack, Joshua J. Ziarek, Jill Tomaras, Haritha R. Chileveru, Yunfei Zhang, Gerhard Wagner, and Elizabeth M. Nolan, “Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide,” J. Am. Chem. Soc. 2014, 136, 13494-13497.

Phoom Chairatana and Elizabeth M. Nolan, “Molecular Basis for the Self-Assembly of a Human Host-Defense Peptide that Entraps Bacterial Pathogens,” J. Am. Chem. Soc. 2014, 136, 13267-13276.

Tengfei Zheng and Elizabeth M. Nolan, “Enterobactin-Mediated Delivery of Beta-Lactam Antibiotics Enhances Antibacterial Activity Against Pathogenic Escherichia coli,” J. Am. Chem. Soc. 2014, 136, 9677-9691.

Megan Brunjes Brophy, Toshiki G. Nakashige, Aleth Gaillard, and Elizabeth M. Nolan, “Contributions of the S100A9 C-Terminal Tail to High-Affinity Mn(II) Chelation by the Host-Defense Protein Human Calprotectin,” J. Am. Chem. Soc. 2013, 135, 17804-17817.

Yunfei Zhang, Fabien B. L. Cougnon, Yoshitha A. Wanniarachchi, Joshua A. Hayden, and Elizabeth M. Nolan, “Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide,” ACS Chem. Biol. 2013, 8, 1907-1911.

Joshua A. Hayden, Megan Brunjes Brophy, Lisa. S. Cunden, and Elizabeth M. Nolan, “High-Affinity Manganese Coordination by Human Calprotectin Is Calcium-Dependent and Requires the Histidine-Rich Site at the Dimer Interface,” J. Am. Chem. Soc. 2013, 135, 775-787.

Andrew J. Wommack, Scott A. Robson, Yoshitha A. Wanniarachchi, Andrea Wan, Christopher J. Turner, Gerhard Wagner, and Elizabeth M. Nolan, “NMR Solution Structure and Condition-Dependent Oligomerization of the Antimicrobial Peptide Human Defensin 5,” Biochemistry 2012, 51, 9624-9637.

Tengfei Zheng, Justin L. Bullock, and Elizabeth M. Nolan, “Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Platforms and Evaluation of Enterobactin-Cargo Conjugate Uptake,” J. Am. Chem. Soc. 2012, 134, 18388-18400.

Megan Brunjes Brophy, Joshua A. Hayden, and Elizabeth M. Nolan, “Calcium Ion Gradients Modulate the Zinc Affinity and Antibacterial Activity of Human Calprotectin,” J. Am. Chem. Soc. 2012, 134, 18089-18100.

Tengfei Zheng and Elizabeth M. Nolan, “Siderophore-Based Detection of Fe(III) and Microbial Pathogens”
(review),  Metallomics 2012, 24, 866-880 (invited contribution to the Emerging Investigators issue).

Yoshitha A. Wanniarachchi, Piotr Kaczmarek, Andrea Wan and Elizabeth M. Nolan, “Human Defensin 5 Disulfide Array Mutants: Disulfide Bond Deletion Attenuates Antibacterial Activity against Staphylococcus aureus,” Biochemistry 2011, 50, 8005-8017.


Postdoctoral

Matthias Strieker, Elizabeth M. Nolan, Christopher T. Walsh and Mohamed A. Marahiel, “Stereospecific Synthesis of threo- and erythro-β-Hydroxyglutamic Acid During Kutzneride Biosynthesis,” J. Am. Chem. Soc. 2009, 131, 13523-13530.

Christopher T. Walsh and Elizabeth M. Nolan, “Chemical Biology and Natural Product Discovery”
(commentary),
ChemBioChem 2009, 10, 24-25.

Elizabeth M. Nolan and Christopher T. Walsh, “How Nature Morphs Peptide Scaffolds into Antibiotics” (review), ChemBioChem 2009, 10, 34-53.

Elizabeth M. Nolan and Christopher T. Walsh, “Investigations of the MceIJ-Catalyzed Posttranslational Modification of the Microcin E492 C-Terminus: Linkage of Ribosomal and Nonribosomal Peptides to Form ‘Trojan Horse’ Antibiotics,” Biochemistry 2008, 47, 9289-9299.

Christopher T. Walsh and Elizabeth M. Nolan, “Morphing Peptide Backbones into Heterocycles” (commentary), Proc. Natl. Acad. Sci. USA, 2008, 105, 5655-5656.

Rebecca F. Roush, Elizabeth M. Nolan, Frank Löhr and Christopher T. Walsh, “Maturation of an Escherichia coli Ribosomal Peptide by ATP-Consuming N—P Bond Formation,” J. Am. Chem. Soc. 2008, 130, 3603-3609.

Elizabeth M. Nolan, Michael A. Fischbach, Alexander Koglin and Christopher T. Walsh, “Biosynthetic Tailoring of Microcin E492m: Post-Translational Modification Affords an Antibacterial Siderophore-Peptide Conjugate,” J. Am. Chem. Soc. 2007, 129, 14336-14347.

Michael L. Neidig, Christina D. Brown, Ken Light, Danica Galonić Fujimori, Elizabeth M. Nolan, John C. Price, Eric W. Barr, J. Martin Bollinger, Jr., Carsten Krebs, Christopher T. Walsh and Edward I. Solomon, “CD and MCD of CytC3 and Taurine Dioxygenase: Role of the Facial Triad in α-KG-Dependent Oxygenases,” J. Am. Chem. Soc. 2007, 129, 14224-14231.


Graduate

Elizabeth M. Nolan and Stephen J. Lippard, “Small-Molecule Fluorescent Sensors for Exploring Zinc Metallo-neurochemistry,” Acc. Chem. Res. 2009, 42, 193-203.

Elisa Tomat, Elizabeth M. Nolan, Jacek Jaworski and Stephen J. Lippard, “Organelle-Specific Zinc Detection Using Zinpyr-Labeled Fusion Proteins in Live Cells,” J. Am. Chem. Soc. 2008, 130, 15776-15777.

Elizabeth M. Nolan and Stephen J. Lippard, “Tools and Tactics for the Optical Detection of Mercuric Ion,” Chem. Rev. 2008, 108, 3443-3480.

Elizabeth M. Nolan and Stephen J. Lippard, “Turn-On and Ratiometric Detection of Mercury in Water with a Red-Emitting Probe,” J. Am. Chem. Soc. 2007, 129, 5910-5918.

Elizabeth M. Nolan, Jubin W. Ryu, Jacek Jaworski, Rodney P. Feazell, Morgan Sheng and Stephen J. Lippard, “Zinspy Sensors with Enhanced Dynamic Range for Imaging Neuronal Cell Zinc Uptake and Mobilization,” J. Am. Chem. Soc. 2006, 128, 15517-15528.

Elizabeth M. Nolan, Jacek Jaworski, Maryann E. Racine, Morgan Sheng and Stephen J. Lippard, “Moderate Affinity Fluorescent Zinc Sensors of the Zinpyr Family: Syntheses, Characterization and Biological Imaging Applications,” Inorg. Chem. 2006, 45, 9748-9757.

Elizabeth M. Nolan, Maryann E. Racine and Stephen J. Lippard, “Selective Hg(II) Detection in Aqueous Solution with Thiol Derivatized Fluoresceins,” Inorg. Chem. 2006, 45, 2742-2749.

Elizabeth M. Nolan, Jacek Jaworski, Ken-Ichi Okamoto, Yasunori Hayashi, Morgan Sheng, and Stephen J. Lippard, “QZ1 and QZ2: Rapid, Reversible Quinoline-Derivatized Fluoresceins for Sensing Biological Zn(II),” J. Am. Chem. Soc. 2005, 127, 16812-16823.

Elizabeth M. Nolan and Stephen J. Lippard, “MS4, a seminaphthofluorescein-based chemosensor for the ratiometric detection of Hg(II),” J. Mater. Chem. 2005, 27-28, 2778-2783 (highlighted in Chemistry World, July 2005).

Christopher J. Chang, Elizabeth M. Nolan, Jacek Jaworski, Ken-Ichi Okamoto, Yasunori Hayashi, Morgan Sheng and Stephen J. Lippard, “ZP8, a Neuronal Zinc Sensor with Improved Dynamic Range; Imagining Zinc in Hippocampal Slices with Two-Photon Microscopy,” Inorg. Chem. 2004, 43, 6774- 6779.

Elizabeth M. Nolan and Stephen J. Lippard, “The Zinspy Family of Fluorescent Zinc Sensors: Syntheses and Spectroscopic Investigations,” Inorg. Chem. 2004, 43, 8310-8317.

Elizabeth M. Nolan, Shawn C. Burdette, Jessica J. Harvey, Scott A. Hilderbrand and Stephen J. Lippard, “Synthesis and Characterization of Zinc Sensors Based on a Monosubstituted Fluorescein Platform,” Inorg. Chem. 2004, 43, 2624-2635.

Christopher J. Chang, Elizabeth M. Nolan, Jacek Jaworski, Shawn C. Burdette, Morgan Sheng, and Stephen J. Lippard, “Bright Fluorescent Chemosensor Platforms for Imaging Endogenous Pools of Neuronal Zinc,” Chem. Biol. 2004, 11, 203-210.

Christopher J. Chang, Jacek Jaworski, Elizabeth M. Nolan, Morgan Sheng, and Stephen J. Lippard, “A Tautomeric Chemosensor for the Ratiometric Fluorescence Imaging of NO-Induced Release of Intracellular Zinc,” Proc. Natl. Acad. Sci. USA 2004, 101, 1129-1134.

Elizabeth M. Nolan and Stephen J. Lippard, “A ‘Turn-On’ Fluorescent Sensor for the Selective Detection of Mercuric Ion in Aqueous Media,” J. Am. Chem. Soc. 2003, 125, 14270-14271 (in Thompson ESI Special Topics, June 2005).


Undergraduate

Elizabeth M. Nolan and R. G. Linck, “Through Space Charge and Dipolar Effects in Substituted Ethanes and 1,1,1-Trifluoroethanes,” J. Phys. Chem. A. 2002, 106, 533-543.

Elizabeth M. Nolan and R. G. Linck, “An Exploration of Long Range Substituent Effects in Substituted Alkanes,” J. Phys. Chem. A. 2001, 105, 7297-7307.

Elizabeth M. Nolan and R. G. Linck, “Charges in Substituted Alkanes: Evidence for a Through Space Mechanism,” J. Am. Chem. Soc. 2000, 122, 11497-11506.


Book Chapters

Elizabeth M. Nolan, “Let’s Visualize Biology: Chemistry and Cellular Imaging,” Letters to a Young Chemist, Abhik Gosh, Ed., Wiley, Chapter 8, 2011.