Innovation Centre: Innovation Grant

ING09007 Water Purification for Remote Location: A portable water purification device to convert seawater/brackish water/contaminated water into potable water, in an energy efficient process that allows low power operation. A new separation technology known as ion depletion separates ions or other charged particles at a nano junction (PI: Jongyoon Han, SMART-MIT).
ING09008 Humanized Mouse Models for Drug Development: Humanized mice model for pharmaceutical industry and applied research of human immunity and hematological diseases (PI: Chen Jianzhu, SMART-MIT).
ING09009 A Three-dimensional Microfluidic Assays for Cancer Drug Screening: The first in vitro quantitative assessment of molecular and cellular level behaviour of metastatic cancer (PI: Roger Kamm, SMART-MIT).
ING09010 High Performance Protein Microarrays: A protein array using a novel random placement of beads containing antibodies on a chip and a method for decoding the placement of such antibodies. The microarrays allow for the performance of vast numbers of experiments at the same time thereby increasing data density and accuracy, speeding up discovery and saving time and money (PI: Dieter Trau, NUS).
ING10012-ICT An Integrated Wireless Sensing Platform for Water Distribution System: An end-to-end system for continuous remote monitoring of a water distribution system, including wireless sensing hardware (for hydraulic, acoustic and water quality parameters), a data collection and visualization infrastructure, modeling and analysis tools (PI: Ami Preis, SMART).
ING10013-BIO Gastro-Duodenal Sleeves: To perform the requisite bench testing, prototyping, and animal studies to prove the concept of a gastro-duodenal sleeve as a substitute for Bariatric surgery for weight reduction in obese patients (PI: Jimmy Soh, NUS).
ING11023-BIO 3D compass navigational tool to augment laparoendoscopy: To develop a standalone three dimensional compass system that provides real time spatial orientation of the endoscope to aid surgeons in advancing and manoeuvring during an endoscopic procedure (PI: Victor Lee, NUS).
ING11027-ENG Silicon-Nanocrystal-Based Anti-Reflection Coating for full-spectrum harvest silicon solar cells: Enhance silicon solar cell efficiency by making use of the leftover solar energy based on the Si nanocrystal (nc-Si) anti-reflective coating (ARC) developed in lab. The low-cost nc-Si ARC effectively converts UV light of the solar spectrum to useful visible light, and at the same time it greatly reduces the reflectance in the near IR-IR regions while the performance in the visible region is not affected (PI: Chen Tupei, NTU).
ING11028-ENG Oxide nanoparticles doped hollow carbon spheres - An anode material of Lithium-ION Battery: Achieving high energy density LIBs (lithium-ion batteries) by doping various metal-oxide nanostructures into a hollow core-shell carbon sphere structure (PI: Yang Hui Ying, SUTD).
ING11031-ICT High Speed Optical Access Networks: A fiber-optic access network which is capable of upgrading the transmission system for internet data traffic on as-needed basis in a cost-effective manner (PI: Hoon KIM, NUS).
ING11032-ICT Mobile Intelligent Travel Agent: To develop a mobile game application and design an open mobile cloud server platform for introducing travelling services from the real world. A variety of terminals including iPhone/iPad and Android will be supported (PI: Miao Chunyan, NTU).
ING11033-ENG A membrane-Based Power Management and Storage Device for Hybrid Vehicles: As a ground-breaking achievement and a continued advancement of the ignition project ING10022-ENG(IGN), the team recently invented the world's first piece of energy-storage membrane for the power management and storage system of hybrid vehicles. The light weight and long cycle life of the membrane help reduce the load and maintenance of vehicles (PI: Xie Xian Ning, NUS).
ING11034-ENG High efficiency, low consumption solar-powered street light: To develop a high-efficient, low-consumption solar-powered street light. The energy is produced directly only when it is needed (PI: Thomas Reindl, NUS).
ING11035-BIO Isolation and purification of Trastuzumab using a MIP (molecularly imprinted particles) system: A low cost system for purifying antibodies with a semi-continuous and a continuous approach (PI: Tong Yen Wah, NUS).
ING11036-BIO Development of an endovascular implant for the treatment of aortic aneurysms: Advancement from ignition grant project no. ING10017-BIO(IGN), the team has developed a novel endovascular implant that seek to overcome the shortcomings of commercially available stent grafts in the treatment of aortic aneurysms (PI: Benjamin Chua, NUS).
ING11037-BIO Multi-channel FTIR for high speed spectrometry: A Multi-Channel FT spectrometer which overcomes known limitations of conventional FT spectrometers through two groundbreaking innovations. Firstly, movable mirror elements are replaced by an arrangement of stepped, micro-fabricated mirror surfaces. Secondly, amplitude beam-splitters are removed (PI: Sascha Pierre Heussler, NUS).
ING12042-BIO A Novel Biodegradable ventilation tube with Sustained Drug-Eluting Property for Treatment of Middle Ear Efusion : A biodegradable ventilation tube for middle ear effusion treatment will reduce the need for topical antibiotic ear drops, and reduce infection or biofilm afflictions of the ventilation tube. (PI : Lim Hsueh Yee Lynne, NUS)
ING12043-BIO Integrated Droplet-Based Microfluidic Platform for High-Throughput Personal Medicine Analysis : A droplet-based microfluidic technology enables the high-throughput screening of a large number of biochemical reactions while using a small amount of patient or other biological sample to facilitate the monitoring of biomolecule activity for diagnostic and drug discovery. Hundreds of enzyme activity bioassays can be used to test clinical samples directly and efficiently. (PI : Chen Chia-Hung, NUS)
ING12044-BIO Light-up Fluorescent Probes for Continuous Monitoring of Live Cell Apoptosis and Drug Screening: New light-up probes have been developed using organic fluorogens with aggregation induced emission characteristics. These probes have no background fluorescence and as a result can provide continuous monitoring of live cell apoptosis and day screening. (PI : Liu Bin, NUS)
ING12045-ENG Development of Robust High-Performance Nanofiltration Membranes for Textile Wastewater Treatment : A hollow fiber nanofiltration membranes is specifically designed for the textile industry. A unique double-repulsive bi-layer can remove > 99% of dye from textile wastewater. The technology is a tailored solution for the textile industry in wastewater treatment. (PI : Chung Tai-Shung, NUS)
ING12046-BIO An automated physio-neuro rehabilitation platform for recovery of hand function after stroke : A rehabilitation platform which targets the recovery of hand function after stroke. It stores brain and muscle data during therapy to automatically personalize therapy. The product is wearable and easy to use at hospital and home for training actions, tasks and cognition. It provides support in acute , sub-acute and chronic stages of recovery. (PI : John Heng, NTU)
ING12052-BIO Generation of autologous pericyte progenitors from peripheral blood for therapeutic angiogenesis-Phase II : A novel cell type called “blood derived angiogenic cells (BDAC)” is derived from the patients peripheral blood. The BDAC cells migrate to the site of injury and facilitate small blood vessel restoration. The BDAC cells can be used to treat diabetic wounds and limb ischema, stroke and MI. (PI : Michael Raghunath, NUS)

Joint Innovation Grant (Jointly Funded Project)

ING08001 A Testing and Verification System for Today's Multicore and Tomorrow's Multiprocessing Systems: Numerical and scientific software solutions for commercial testing and verification of programs used in multi-processing systems (PIs: Alan Edelman, MIT and Teo Yong-Meng, NUS).
ING08002 Software for Design and Optimization of Nanofilters: A novel filter structure for lab-on-a-chip systems for biomedical applications, micro-/nano-fabricated fluidic systems which have great potential in preparation, separation and analysis of various biomolecules (PIs: Jongyoon Han, SMART-MIT and Khoo Boo Cheong, NUS).
ING08003 Imaging Through Opaque Media: An optical device that allows imaging through opaque mediums such as muddy-water for underwater surveillance and threat detection of suspicious objects such as mines, bombs and other criminal cargos underwater-attached to ships entering harbors (PIs: George Barbastathis, SMART-MIT and Colin J. R. Sheppard, NUS).
ING08004 Lattice Engineered Substrates for Disruptive Electronics: Processes to create silicon-based engineered wafers that would allow for the creation of new electronics and optoelectronics integrated circuits (PIs: Eugene A. Fitzgerald, SMART-MIT and Yoon Soon Fatt, NTU).

Ignition Grant (Proof of Principal Grant)

ING09005(IGN) Terahertz Swept Source Optical Coherence Tomography: A laser imaging system for the thicknesses measurement of polymer layers using terahertz frequency light (PI: Qing Hu, MIT).
ING09006(IGN) A Platform to Prime Peripheral Blood Monocytes for Induction into Multi-and Pluripotency: A new break-through technology to convert autologous somatic cells (i.e. peripheral blood monocytes) into induced pluripotent stem cells (IPS) (PI: Michael Raghunath, NUS).
ING09011(IGN) Vector Control of Dengue Mosquito Larvae/Pupae Using Ultrasound: Using portable ultrasound to destroy mosquito breeding (PI: Alfred Tan, SMART-MIT).
ING10015-BIO(IGN) Modeling Human Liver Cancer in Humice: Construct a human Hepatocellular carcinoma (HCC) mouse model with oncogene-modified human hepatocyte progenitors and use it as a platform for studying anti-HCC modeling therapy. The same approach will be applicable to other non-hematopoietic stem cells to construct different tissue-specific cancer models. It is anticipated that such humanized mouse models will greatly facilitate the development of anti-tumor drugs and other therapeutic strategies (PI: Chen Jianzhu, SMART-MIT).
ING10016-BIO(IGN) Isolation and Purification of Heparin: Heparin is one of the oldest drugs in the market and it is commonly used as an anticoagulant. The aim of our project is to simultaneously isolate heparin from porcine tissue and cleanse it of infectious prions and viruses using molecularly imprinted polymers (MIPs) (PI: Tong Yen Wah, NUS).
ING10017-BIO(IGN) An Endovascular Implant for the Treatment of Aortic Aneurysms: To develop and evaluate the feasibility of a novel endovascular implant that will overcome the shortcomings of commercially available stent grafts in the treatment of aortic aneurysms (PI: Benjamin Chua, NUS).
ING10018-BIO(IGN) Platform Technology to Enhance Affinities of Antibodies: Propose to strategically incorporate proline residues in the flanking segments of complementarity determining regions (CDRs) to enhance binding efficiency of single-chain variable antibody (scFv6) (PI: R Manjunatha Kini, NUS).
ING10019-BIO(IGN) Adaptable Optical Microscopy Technology: Employ a large illumination aperture and incoherent source to perform label-free live cell imaging thereby providing a tool for quantitative high-resolution and label-free analysis of cellular morphology (PI: Colin J.R. Sheppard, NUS).
ING10020-ENG(IGN) Integrated Micro Fuel Cells on Porous Silicon: To provide a novel design and fabrication of monolithically integrated micro fuel cells on silicon with stable and high energy density (PI: Seyed Ali Mousavi Shaegh, NTU).
ING10021-ICT(IGN) WiFi Solution for High Data Rate Requirements: A wireless network solution for enterprise and community networks that has been primarily designed to cater to the exploding growth in Wi-Fi technology use (PI: Mehul Motani, NUS).
ING10022-ENG(IGN) Applications for Nanosegregant-Engineered Resins/Membranes: Newly invented nanomaterial, to engineer high performance capacitors for energy storage as well as other applications using unique properties of the material (PI: Xie Xian Ning, NUS).
ING11024-BIO(IGN) Generation of autologous pericyte progenitors from peripheral blood for therapeutic angiogensis: Pericytes are specialized cells that facilitate blood vessel formation, maintenance and function. The team has developed a proprietary process to grow potential pericyte progenitors from peripheral blood in therapeutically relevant amounts. These cells represent a potential breakthrough in cell-based therapy. Project will seek to fully characterize these cells functionally in vitro, establish a patentable marker profile, and to confirm their homing behavior in animal models (PI: Michael Raghunath, NUS).
ING11025-BIO(IGN) μMagnetic Resonance Relaxometry for label-free, rapid malaria diagnosis: new system for sensitive, quantitative and rapid detection of parasitemia level in malaria parasites infected red blood cells (iRBCs) by means of based Magnetic Resonance Relaxometry (MRR) (PI: Peng Weng Kung, SMART).
ING11026-BIO(IGN) Partially biodegradable percutaneous caval valve implantation for severe tricuspid regurgitation: Aims to create a competent unidirectional valve in the superior and inferior vena cava. This serves to prevent high systolic pressures to be transmitted distally to the end organs, permit improved forward flow and translate into improved symptoms (PI: Edgar Tay, NUS).
ING11029-ENG(IGN) A Hybrid Composite Desiccant/Nano-Woven Membrane Air Dehumidifier for Warm and Humid Climates: To dehumidify moist air using a novel hybrid system integrating composite desiccant/nano-woven membrane. The hybrid system promotes energy efficiency in high latent load removal and allows greater capacity for air dehumidification particularly when low humidity is desired. Focus on developing the state-of-the-art dehumidification technology for cooling in buildings to dramatically improve energy efficiency. A commercial turn-key product is expected soon and will enable new levels of filtration performance in diverse applications with a broad range of environments and contaminants (PI: Ernest Chua, NUS).
ING11030-ENG(IGN) Solution-Processed Conducting Polymers for Transparent Electrode of Optoelectronic Devices: Develop novel approaches to prepare solution-processed conducting polymer films with conductivity and transparency comparable to Indium tin oxide (ITO) (PI: Ouyang Jianyong, NUS).
ING11038-BIO(IGN) Development of paclitaxel precursor high producing strains of GRAS Bacterium Bacillus subtilis: Aim to produce safer and more practical in pharmaceutical industry by using a Generally Recognized As Safe (GRAS, FDA designation) bacterium Bacillus subtilis. The high production strains will be intellectually protected as these can be used for the productions of other isoprenoids with commercial potentials (PI: Too Heng-Phon, NUS).
ING11039-BIO(IGN) Novel Glaucoma Drainage Device: Glaucoma Drainage Devices (GDD) design contains novel features for the drainage tube and plate that not only reduce failure and post-operative complications, but are also easier to deploy (PI: Paul Chew, NUS).
ING11040-BIO(IGN) Targeted liver cancer drug delivery through sugar-functionalized nanoparticles: To perform proof-of-concept test of a novel sugar-targeted nanoparticles drug delivery method to liver cancer using existing drug Nexavar (sorafenib) (PI: Ge Ruowen, NUS).
ING12047-BIO(IGN) Adapting (Niche Biology for the ex vivo Expansion of (Mesenchymal Stem Cells (MSCs) Towards Off-The-Shelf Therapeutics) : The system will produce therapeutically relevant quantities of mesenchymal stem cells in ex vivo culture without the loss of their biological potency. This will result in more potent therapeutics using MSCs. (PI :Krystyn Van Vliet, SMART)
ING12048-BIO(IGN) A Field-Friendly Immune Surveillance System : Development of a point-of-care field-friendly system to assess exposure to infectious agents or the effectiveness of their vaccines. The vaccines uses a microarray-based technology and can be customized according to the range of pathogens/vaccine panels to be screened. (PI : Megan McBee, SMART)
ING12049-BIO(IGN) “Photopette” – Reinventing the Photometer for the Modern Life-Scientist : An entire spectrophotometer has been encorporated into a handheld pipette to serve the modern researcher in life-science/molecular biology/microbiology/pharma labs. It provides spectrophotometric measurements with an ultra convenient handling and a simple and fast work flow. ( PI : Dieter Trau, NUS)
ING12050-ENG(IGN) Super UV Luminescence from Hydrogen-doped Single ZnO Nanorod: Property Evaluation and Optimization at Nanoscalen : An improvement in the UV emission of solution-grown ZnO nanorods through hydrogen doping has been developed. This makes possible nanoscale UV Luminescence sources and lasers. The use of solution grown ZnO nanorods can also impact solid state lighting and solar cells. (PI : Chua Soo Jin, NUS)
ING12051-ENG(IGN) Development of Green and Recyclable Supported Metal Nanoparticles-Based Catalysts for Oxidation Reactions of Biomass-derived Alcohols : Heterogeneous nanoparticle based catalysts have been developed which can be removed by filtration or centrifugation at the end of the reaction. The application will be for selective oxidation of alcohols to their corresponding aldehydes on ketones for industrial application. ( PI : Zhu Yinghuai, A*Star)