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Optical Imaging of Pre-Cancer in the Esophagus

The incidence of cancer of the esophagus is increasing rapidly in the Western world. Chronic gastroesophageal reflux disease leads to a premalignant change in the esophageal epithelium, known as Barrett’s esophagus, and this can progress to dysplasia and adenocarcinoma. The traditional method of detecting these changes employs endoscopy and taking of multiple biopsies. This workshop will discuss non-invasive optical methods of detecting and monitoring esophageal precancer, including optical coherence tomography, tri-modal spectroscopy and endoscopic confocal microscopy.

Screening and Surveillance of Barrett's Esophagus: The Challenge, Current Status and Opportunities
Norman Nishioka, Massachusetts General Hospital and Harvard Medical School

Upper Gastrointestinal Optical Coherence Tomography
Brett Bouma, Massachusetts General Hospital and Harvard Medical School

Real-Time Spectral Diagnosis of Dysplasia in Barrett's Esophagus
James Tunnell, MIT Spectroscopy Laboratory

Endoscopic Confocal Microscopy for Structure and Function
Gordon Kino, Stanford University

Tuesday, April 12, 2004; 4:00 - 6:00 PM
Wellman 1 Conference Room; MGH Campus
50 Blossom Street, Boston

Refreshments served at 3:30 PM

Sponsored by the George R. Harrison Spectroscopy Laboratory, MGH Wellman Center for Photomedicine, Harvard-MIT Division of Health Sciences and Technology, and CIMIT (Center for the Integration of Medicine and Innovative Technology)