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Seminar on
Modern Optics and Spectroscopy

Obrad Scepanovic, MIT

"Multimodal spectroscopy of vulnerable plaque"

November 20 , 2007

12:00 noon - 1:00 p.m. Grier Room 34-401


The combination of reflectance, fluorescence, and Raman spectroscopy - which we term multimodal spectroscopy (MMS) - can provide complementary and depth-sensitive information about tissue composition. We present an overview of the development of MMS into a clinical technique for detecting vulnerable atherosclerotic plaque, which is done through four main areas. In the first, we show that MMS can provide spectral markers indicative of the presence of morphological features of vulnerable plaque. Having established the motivation, the next step describes the mathematical tools used to extract quantitative spectral parameters and, moreover, to assess the uncertainty and confidence of the spectral information. In order to apply the mentioned methodology, in the third step we describe the development of a compact and practical clinical MMS instrument and an efficient, specialized MMS probe for data acquisition. Lastly, we describe preliminary results from a clinical study of vulnerable plaque as an important step in clinical translation of the MMS technique.


TUESDAYS, 12:00-1:00, GRIER ROOM (34-401)
Refreshments served following the seminar

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Co-sponsored by the George R. Harrison Spectroscopy Laboratory,
the Department of Electrical Engineering and Computer Science and
the School of Science, Massachusetts Institute of Technology.