Seminar on
Modern Optics and Spectroscopy


Stephen Coy, Sionex Corporation

"The Power of Differential Ion Mobility: Ion Filtration, Ion Dissociation Kinetics, Analytical Mass Spectrometry"

November 6, 2007

12:00 noon - 1:00 p.m. Grier Room 34-401


Abstract:

Ion mobility spectrometry is an active area of current research and device development with over 100 related publications so far in 2007 alone. Ion mobility techniques share simplicity, speed, and a range of scientific and analytical capabilities, The richness of ion response to static and dynamic electric fields in gases at near atmospheric pressure is exploited to separate mixtures of ion species from 19 Da to 30 kDa and higher. Separation is based on properties including ion conformation, structural rigidity, clustering affinity, field alignment, and geometric profiles. Structural isomers, isobaric compounds, and even racemic mixtures can be resolved. Very high field techniques like Differential Mobility Spectrometry (DMS / planar FAIMS) also reveal unimolecular decomposition and reaction processes similar to CID in mass spectrometry. In biological, pharmaceutical, and diagnostic applications, DMS-prefiltered mass spectrometry separates species in complex mixtures in milliseconds, and can often replace LC techniques taking much longer.

TUESDAYS, 12:00-1:00, GRIER ROOM (34-401)
Refreshments served following the seminar

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Co-sponsored by the George R. Harrison Spectroscopy Laboratory,
the Department of Electrical Engineering and Computer Science and
the School of Science, Massachusetts Institute of Technology.