FibronectinFibronectinFibronectin
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Recent
  1. Stern, P., Astrof, S., Erkeland, S.J., Schustak, J., Sharp, P.A. and Hynes, R.O. (2008). A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA  105:13895-13900.
  2. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L.  (2008).  EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1.  J. Biol. Chem. 283: 2858-2870.
    4. Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O.  (2008).  Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
  4. Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R.O., Walsh, C.A., Corfas, G. and Piao, X.  (2008) GPR56 regulates pial basement membrane integrity and cortical lamination, J. Neurosci. 28:5817-5826.
  5. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008).  Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747.
  6. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clin. Exp. Metastasis 25: 109-118.
  7. Astrof, S., Crowley, D. and Hynes, R.O. (2007).  Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24.
  8. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  9. Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007).  Protein 4.1B suppresses prostate cancer progression and metastasis.  Proc. Natl. Acad. Sci. USA 104: 12784-12789.
  10. Astrof, S., Kirby, A., Lindblad-Toh, K, Daly, M. and Hynes, R.O. (2007).   Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech. Devel. 124:551-8.
  11. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007).  a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
  12. Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007).  Importance of donor- and recipient-derived selectins in cardiac allograft rejection.  J. Am. Soc. Nephrol. 18:2929-2936
  13. Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5
  14. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006).  The echinoderm adhesome.  Dev. Biol. 300: 252-266.
  15. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101:840-50.
  16. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109:3284-90.
  17. Sea Urchin Genome Sequencing Consortium, (2006). The genome of the sea urchin Strongylocentrotus purpuratus.  Science 314:941-952.
  18. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
  19. Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O.  (2006).  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc. Natl. Acad. Sci. USA. 103: 9023-9028.
  20. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
  21. Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006).  Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
  22. McCarty, J.H. and Hynes, R.O. (2007).  Endothelial cell integrins. in Endothelial Biomedicine, Aird, W.C (Ed.).  Cambridge University Press, Cambridge and New York.
  23. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).   A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.        Blood 107:2976-2983.
Reviews/Books
  1. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  2. McCarty, J.H. and Hynes, R.O. (2006).  Endothelial cell integrins. in The Endothelium: A Comprehensive Reference.  Ed. William C. Aird.  Cambridge University Press, New York.
  3. Xu, L. and Hynes, R.O. (2006). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5.
  4. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101(4):840-50.
  5. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006).  The echinoderm adhesome.  Dev. Biol. 300: 252-266.
  6. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
  7. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  8. Moreno J.D. and Hynes, R.O. (2005).  Guidelines for human embryonic stem cell research.  Nat Biotechnol. 23:793-794.
  9. Hynes, R.O. (2004). The emergecnce of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
  10. Hynes, R.O. (2003). Changing Partners. Science: 300: 755-756.
  11. Hynes, R.O. (2002) Integrins: bi-directional, allosteric, signaling machines. Cell. Vol. 110: 673-687.
  12. Hynes, R.O. (2002) A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.
  13. Hynes, R.O. (2000). Whither Cell Biology? The Scientist. 14: 43.
  14. Hynes, R.O. and Zhao, Q. (2000). The evolution of cell adhesion. J.Cell Biol. 150:F89-F95.
  15. Rubin, G.M. et al. (2000). Comparative genomics of the eukaryotes. Science 287:2204-2215.
  16. Hynes, R.O. (1999). Cell adhesion: old and new questions. Trends Millenium Issue. M33-37.
  17. Hynes, R.O., Bader, B.L. and Hodivala-Dilke, K. (1999) Integrins in vascular development. Brazilian J. Medical and Biological Res..32:501-510.
  18. Tsakiris, D.A., Smyth, S., Scudder, L., Hodivala-Dilke, K., Hynes, R.O. and Coller, B.S. (1999). Hemostasis in the mouse, Mus musculus: a review. Thrombosis and Haemostasis 81:177-188.
  19. Clark, E. A. and Hynes, R.O. (1997) Meeting report. 1997 Keystone Symposium on Signal Transduction by Cell Adhesion Receptors. BBA Reviews on Cancer. 1333: R9-R16.
  20. Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
  21. Hynes, R.O. and Wagner, D.D. (1996) Genetic manipulation of vascular adhesion molecules in mice. J.Clin. Invest., 98: 2193-2195
  22. Hynes, R.O. (1996) Targeted mutations in cell adhesion genes: what have we learned from them? Devel. Biol. 180: 402-412.
  23. Wagner, D.D. and Hynes, R.O. (1996). Gene targeting of adhesion molecules in the vasculature. In: Molecular Genetics and Gene Therapy of Cardiovascular Diseases. S.C. Mockrin, Ed. Marcel Dekker, New York. pp. 403-425.
  24. Hynes, R.O. (1994). The impact of molecular biology on models for cell adhesion. Bioessays 16:663-669.
  25. Gotwals, P. Paine-Saunders, S., Stark, K., and Hynes, R. O. (1994). Drosophila integrins and their ligands. Curr. Opin. in Cell Biol. 6:734-739.
  26. Hynes, R.O. (1994). Genetic analyses of cell-matrix interactions in development. Current Opin. in Genetics and Devel. 4:569-574.
  27. George, E. L. and Hynes, R.O. (1994). Gene targeting and generation of mutant mice for studies of cell-extracellular matrix interactions. Methods in Enzymology 245:386-420.
  28. Hynes, R.O. (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69:11-25.
  29. Hynes, R.O. and Lander, A.D. (1992). Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68:303-322.
  30. Hynes, R.O. (1990). Fibronectins. Springer-Verlag, New York.
  31. Hynes. R.O., Schwarzbauer, J.E. and Tamkun, J.W. (1987). Isolation and analysis of cDNA and genomic clones of fibronectin and its receptor. in Methods in Enzymology (L.W. Cunningham, ed). 144:447-463.
  32. Lawler, J. and Hynes, R.O. (1987). Structural Organization of the Thrombospondin Molecule. in Seminars in Thrombosis and Hemostasis. 13:245-253. (Thieme Medical Publishers, Inc. New York, NY).
  33. Hynes, R.O. (1987). Integrins: a family of cell surface receptors. Cell, 48:549-554.
  34. Hynes, R.O. (1987). Fibronectins: a family of complex and versatile adhesive glycoproteins derived from a single gene. "The Harvey Lectures", 81:133-152.
  35. .Hynes, R.O. (1986). Fibronectins . Scientific American, 254:42-51.
  36. Hynes, R.O. (1985). Molecular Biology of Fibronectin. Ann. Rev. Cell Biol. 1:67-90.
  37. Hynes, R.O. and Yamada, K.M. (1982). Fibronectins: multifunctional modular glycoproteins. J. Cell Biol. 95:369-377.
  38. Hynes, R.O. (1981). Fibronectin and its relation to cellular structure and behαvior. In, "The Cell Biology of the Extracellular Matrix", ed. E.D. Hay, Plenum Press, pp. 295-333.
  39. Hynes, R.O. (1981). Relationships between fibronectin and the cytoskeleton, In, "Cytoskeletal Elements and Plasma Membrane Organization" Cell Surface Reviews 7:97-139, eds. G. Poste and G.L. Nicolson, Elsevier-Biomedical Press.
  40. Hynes, R.O. and Fox, C.F. editors. (1980). "Tumor Cell Surfaces and Malignancy", Alan R. Liss, Inc., New York.
  41. Hynes, R.O. editor. (1979). "Surfaces of Normal and Malignant Cells". John Wiley and Sons
  42. Hynes, R.O. (1976). Surface labelling techniques for eukaryotic cells, in "New Techniques in Biophysics and Cell Biology", 3:147-212, (R. Pain and B.J. Smith, eds.) Wiley International Publishers.
  43. Hynes, R.O. (1976). Cell surface proteins and malignant transformation. Biochim. Biophys. Acta 458:73-107.
  44. Hynes, R.O. (1974). Role of surface alterations in cell transformation: the importance of proteases and surface proteins. Cell 1:147-158.

 

Cancer

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  1. Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O.  (2008).  Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
  2. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clin. Exp. Metastasis 25: 109-118.
  3. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008).  Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.  Am. J. Path. 172:1740-1747.
  4. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101: 840-850.
  5. Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6:160-165.
  6. Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007).  Protein 4.1B suppresses prostate cancer progression and metastasis.  Proc. Natl. Acad. Sci. USA 104: 12784-12789.
  7. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2007).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clinical & Experimental Metastasis (Ms in press).
  8. Xu, L. and Hynes, R.O. (2006). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5.
  9. Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O.  (2006).  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc. Natl. Acad. Sci. USA. 103: 9023-9028.
  10. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
  11. Taverna, D., Crowley, D., Connolly, M., Bronson, R.T. and Hynes, R.O.  (2005). A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas.  Cancer Res. 65: 10324-10329.
  12. Wong, S.Y., Haack, H., Crowley, D., Barry, M., Bronson, R.T. and Hynes. R.O. (2005). Tumor-secreted VEGF-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.  Cancer Res. 65: 9789-9798.
  13. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004).  Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.  Mol. Cell. Biol. 24: 8662-8670.
  14. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins. Proc. Natl. Acad. Sci. USA 101: 763-768.
  15. Hynes, R.O. (2003). Metastatic potential: generic predisposition of the primary tumor or rare, highly metastatic variants—or both? Cell 113: 1-3.
  16. Borsig, L., Wong, R., Hynes, R.O., Varki, N.M. and Varki, A. (2002). Synergistic effect of L- and P-selectin in facilitating tumor metastasis in a syngeneic system involving non-mucin ligands - further evidence for selectin inhibition as a mode of heparin action. Proc. Natl. Acad. Sci. USA 99: 2193-2198.
  17. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
  18. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
  19. Lawler, J., Miao, W.M., Duquette, M., Bouck, N., Bronson, R.T. and Hynes, R.O. (2001). Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am.J. Path. 159: 1949-1956
  20. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J. and Iruela-Arispe, M.L. (2001). Thrombospondin-1 suppresses spontaneous tumor growth and angiogenesis and inhibits activation of matrix metalloprotease-9 and mobilisation of VEGF. Proc. Natl. Acad. Sci. USA 98: 12485-12490.
  21. Clark, E.A., Golub, T.R., Lander, E. and Hynes, R.O. (2000) Genomic analysis of metastasis reveals an essential role for rhoC. Nature, 406: 532-535.
  22. Taverna, D., Ullman-Culleré, M., Rayburn, H., Bronson, R.T. and Hynes, R.O. (1998). A test of the role of α5 integrin/fibronectin interactions in tumorigenesis. Cancer Res., 58: 848-853.
  23. Stellmach, V., Volpert, O.V., Crawford, S.E., Lawler, J., Hynes, R.O. and Bouck, N. (1997) Tumor suppressor genes and angiogenesis: the role of p53 in fibroblasts. Eur. J. Cancer 32A: 2394-2400.
  24. Hynes, R.O., and Plantefaber, L.C. (1991). Integrin receptors for extracellular matrix and their involvement in oncogenic transformation. In Origins of Human Cancer: A Comprehensive Review (Brugge, J., Curran, T., Harlow, E and McCormick, F.). Plainview, NY: Cold Spring Harbor. pp. 293-307.
  25. Plantefaber, L.C. and Hynes, R.O. (1989). Changes in integrin receptors on oncogenically transformed cells. Cell 56:281-290.
  26. Wagner, D.D., Ivatt, R., Destree, A.T. and Hynes, R.O. (1981). Similarities and differences between the fibronectins of normal and transformed hamster cells. J. Biol. Chem. 256:11708-11715.
  27. Senger D.R., Wirth, D.F., Bryant, C. and Hynes, R.O. (1980). Transformation-specific secreted proteins in "Viral Oncogenes", Cold Spring Harbor Symposia 44:651-657.
  28. Senger, D.R., Wirth, D.F. and Hynes, R.O. (l980). Transformation-specific secreted phosphoproteins. Nature 286:619-621.
  29. Senger, D.R., Wirth, D.F. and Hynes, R.O. (1979). Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 16:885-894.
  30. Mautner, V.M. and Hynes, R.O. (1977). Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed fibroblasts. J. Cell Biol. 75:743-768.
  31. Ali, I.U., Mautner, V.M., Lanza, R.P. and Hynes, R.O. (1977). Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell 11:115-126.
  32. Critchley, D.R., Wyke, J.A. and Hynes, R.O. (1976). Cell surface and metabolic labelling of the proteins of normal and transformed chicken cells. Biochim. Biophys. Acta 436:335-352.
  33. Hynes, R.O. (1976). Cell surface proteins and malignant transformation. Biochim. Biophys. Acta 458:73-107.
  34. Hynes, R.O. and Wyke, J.A. (1975). Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus. Virology 64:492-504.
  35. Hynes, R.O. (1974). Role of surface alterations in cell transformation: the importance of proteases and surface proteins. Cell 1:147-158.
  36. Hynes, R.O. (1973). Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc. Natl. Acad. Sci. USA 70:3170-3174.

 

Angiogenesis
  1. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  2. McCarty, J.H. and Hynes, R.O. (2007).  Endothelial cell integrins. in Endothelial Biomedicine, Aird, W.C (Ed.).  Cambridge University Press, Cambridge and New York.
  3. Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101(4):840-50.
  4. Wong, S.Y. and Hynes, R.O. (2006). Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?  Cell Cycle 5: 812-817.
  5. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  6. Wong, S.Y., Haack, H., Crowley, D., Barry, M., Bronson, R.T. and Hynes. R.O. (2005). Tumor-secreted VEGF-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.  Cancer Res. 65: 9789-9798.
  7. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D.H., Savill, J. and Hynes, R.O.  (2005).  Selective ablation of av integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.  Development 132:165-176.
  8. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004). Direct test of potential roles of EIIIA and EIIIB alternatively spliced variants of fibronectin in physiological and tumor angiogenesis. Mol. Cell Bio. 19: 8662-8670.
  9. Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003). Physiological levels of tumstatin, a fragment of collagen IV a3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin. Cancer Cell 3: 589-601.
  10. Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Xiao, Q. and Hodivala-Dilke, K. (2002). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.
  11. Hynes, R.O. (2002) A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.
  12. McCarty, J.H., Monahan-Earley, R.A., Dvorak, A.M., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Wolburg, H., Bader, B.L., Dvorak, H.F. and Hynes, R.O. (2002). Defective associations between blood vessels and developing neuronal parenchyma lead to cerebral hemorrhage in mice lacking αv integrins. Mol. Cell. Biol. 22: 7667-7677.
  13. Francis, S.E., Goh, K.L., Hodivala-Dilke, K., Bader, B.L., Stark, M., Davidson, D. and Hynes, R.O. (2002). Central roles of α5 β1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis and Vasc. Biol. 22: 927-933.
  14. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002).αvΒ3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
  15. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
  16. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J. and Iruela-Arispe, M.L. (2001). Thrombospondin-1 suppresses spontaneous tumor growth and angiogenesis and inhibits activation of matrix metalloprotease-9 and mobilisation of VEGF. Proc. Natl. Acad. Sci. USA 98: 12485-12490.
  17. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
  18. Hynes, R.O., Bader, B.L. and Hodivala-Dilke, K. (1999) Integrins in vascular development. Brazilian J. Medical and Biological Res..32:501-510.
  19. Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O. (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all αv integrins. Cell 95: 507-519.
  20. Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
  21. George, E.L., Baldwin, H.S. and Hynes, R.O. (1997). Fibronectins are essential for heart and blood vessel morphogenesis, but are dispensible for initial specification of precursor cells. Blood 90: 3073-3086.
  22. Yang, J.T., Rayburn, H. and Hynes, R.O. (1993) Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119:1093-1105.
  23. George, E.L., Georges-Labouesse, E.N., Patel-King, R.S., Rayburn, H. and Hynes, R.O. (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079-1091.

 

Thrombosis & Hemostasis
  1. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  2. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
  3. Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006).  Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
  4. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood 107:2976-2983.
  5. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., and Wilcox, D.A. (2005). Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia. Blood. 106:2671-2679.
  6. Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O. and Leong, J.M (2003). Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis. Blood. 102:2843-50.
  7. Ni, H., Yuen, P.S.T., Papalia, J.M., Trevithick, J.E., Sakai, T., Fässler, R., Hynes, R.O. and Wagner, D.D. (2003) Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc. Natl. Acad. Sci. USA 100: 2415-2419.
  8. Andre, P., Srinivasa, P., Denis, C.V., Papalia, J.M., Hynes, R.O., Phillips, D.R. and Wagner, D.D. (2002). CD40L stabilizes arterial thrombi by a β3-integrin-dependent mechanism. Nature Medicine 8: 247-252.
  9. Andre, P., Denis, C.V., Ware, J., Saffaripour, S., Hynes, R.O., Ruggeri, Z.M. and Wagner, D.D. (2000). Platelets adhere and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood 96: 3322-3328.
  10. Ni, H., Denis, C.V., Subbarao, S., Sato, T.N., Degen, J.L., Hynes, R.O. and Wagner, D.D. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand and fibrinogen. J. Clin. Invest. 106: 385-392.
  11. Hodivala-Dilke, K.M., McHugh, K., Tsakiris, D.A., Rayburn, H., Crowley, D. , Ullman-Culleré, M., Ross, F.P., Coller, B.S., Teitelbaum, S. and Hynes, R.O. (1999). β3-integrin-deficient mice: a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J.Clin. Invest. 103: 229-238.
  12. Hynes, R.O. and Hodivala-Dilke, K. (1999) Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thrombosis and Haemostasis, 82: 481-485.
  13. Tsakiris, D.A., Smyth, S., Scudder, L., Hodivala-Dilke, K., Hynes, R.O. and Coller, B.S. (1999). Hemostasis in the mouse (Mus musculus): a review. Thrombosis and Haemostasis 81:177-188.
  14. Denis. C., Methia, N., Frenette, P.S., Rayburn, H., Ullman-Culleré, M., Hynes, R.O. and Wagner, D.D. (1998). A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc. Natl. Acad. Sci. USA. 95: 9524-9529.
  15. Hynes, R.O. (1991). The complexity of platelet adhesion to extracellular matrices. Thrombosis and Haemostasis. 66:40-43.
  16. Hynes, R.O. (1986). The interactions of fibronectin with platelets. in "Biology and Pathology of the Platelet - Vessel Wall Interactions" (G. Jolles, Y. Legrand and A.T. Nurden, eds.). Academic Press Inc., London. pp. 75-91.
  17. Lahαv, J., Schwartz, M.A. and Hynes, R.O. (1982). Analysis of platelet adhesion using a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31:253-262.
  18. Lahαv, J. and Hynes, R.O. (1981). Involvement of fibronectin, von Willebrand Factor, and fibrinogen in platelet interaction with solid substrata. J. Supramol. Struct. and Cell Biochem. 17:299-311
Fibronectins in vivo
  1. Astrof, S., Kirby, A., Lindblad-Toh, K., Daly, M.J. and Hynes, R.O. (2007).  Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four.  Mech. Dev. 124: 551-558.
  2. Astrof, S., Crowley, D. and Hynes, R.O. (2007).  Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24.
  3. Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006).  Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
  4. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  5. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004). Direct test of potential roles of EIIIA and EIIIB alternatively spliced variants of fibronectin in physiological and tumor angiogenesis. Mol. Cell Bio. 19: 8662-8670.
  6. Peters, J.H., Loredo, G.A., Chen, G., Maunder, R., Hahn, T.J.,Willits, W. and Hynes.R.O. (2003). Plasma levels of fibronectin bearing the alternatively spliced EIIIB segment are increased in patients following major trauma. J.Lab. Clin. Med. 141: 401-410.
  7. George, E.L., Baldwin, H.S. and Hynes, R.O. (1997). Fibronectins are essential for heart and blood vessel morphogenesis, but are dispensible for initial specification of precursor cells. Blood 90: 3073-3086.
  8. Georges-Labouesse, E.N., George, E.L., Rayburn, H. and Hynes, R.O. (1996) Mesodermal development in murine embryos mutated in the fibronectin gene Developmental Dynamics 207:145-156
  9. Peters, J. H., Chen, G., and Hynes, R.O. (1996) Fibronectin isoform distribution in the mouse II. Differential distribution of the alternatively spliced EIIIB, EIIIA and V segments in the adult mouse. Cell Adhesion and Comm., 4: 126-148.
  10. Peters, J. H., and Hynes, R.O. (1996) Fibronectin isoform distribution in the mouse I. The alternatively spliced EIIIB, EIIIA and V segments show widespread codistribution in the developing mouse embryo. Cell Adhesion and Comm., 4: 103-125.
  11. Peters, J., Trevithick, J.E., Johnson, P. and Hynes, R.O. (1995). Expression of the alternatively spliced EIIIB segment of fibronectin. Cell Adhes. and Commun. 3:67-89.
  12. Nickeleit, V., Zagachin, L., Nishikawa, K., Peters, J.H., Hynes, R.O. and Colvin, R.B. (1995). Embryonic fibronectin isoforms are synthesized in crescents in experimental autoimmune glomerulonephritis in the rat.). Amer. J. Path. 147:965-978.
  13. George, E.L., Georges-Labouesse, E.N., Patel-King, R.S., Rayburn, H. and Hynes, R.O. (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079-1091.
  14. ffrench-Constant, C., Hynes, R.O., Heasman, J., Wylie, C.C. (1992). Fibronectins and embryonic cell migration. In: Formation and Differentiation of Early Embryonic Mesoderm. ed. Bellairs, R. et al. Plenum Press, New York. pp. 99-108.
  15. Smith, J.C., Symes, K., Hynes, R.O. and DeSimone, D. (1990). Mesoderm induction and the control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins. Development 108:229-238.
  16. ffrench-Constant, C., Van De Water, L., Dvorak, H.F. and Hynes, R.O. (1989). Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J. Cell Biol. 109:903-914.
  17. ffrench-Constant, C. and Hynes, R.O. (1989). Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo. Development 106:375-388.
  18. ffrench-Constant, C. and Hynes R.O. (l988). Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos. Development 104:369-382.
  19. Hynes, R.O., Patel, R. and Miller, R.H. (1986). Migration of neuroblasts along preexisting axonal tracts during prenatal cerebellar development. J. Neuroscience 6:867-876.
  20. Lee, G., Hynes, R.O. and Kirschner, M. (1984). Temporal and spatial regulation of fibronectin in early Xenopus development. Cell 36:729-740.
    Heasman, J., Hynes, R.O., Swan, A.P., Thomas, V. and Wylie, C.C. (1981). Primordial germ cells of Xenopus embryos: the role of fibronectin in their adhesion during migration. Cell 27:437-447.
  21. Mayer B.W., Jr., Hay, E.D. and Hynes, R.O. (1981). Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Dev. Biol. 82:267-286
  22. Courtoy, P.J., Kanwar, Y.S., Hynes, R.O. and Farquhar, M.G. (1980). Fibronectin localization in the rat glomerulus. J. Cell Biol. 87:691-696.
  23. Critchley, D.R., England, M.A., Wakely, J. and Hynes, R.O. (1979). Distribution of fibronectin in the ectoderm of gastrulating chick embryos. Nature 280:498-500.
  24. Schachner, M., Shoonmaker, G. and Hynes, R.O. (1978). Cellular and subcellular localization of LETS protein in the nervous system. Brain Res. 158:149-158.
Fibronectins-Cell Biology
  1. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L.  (2008).  EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1.  J. Biol. Chem. 283: 2858-2870.
  2. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007).  a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
  3. Price, J. and Hynes, R.O. (1985). Astrocytes in culture synthesize and secrete a variant form of fibronectin. J. Neuroscience, 15:2205-2211.
  4. Senger, D.R., Destree, A.T. and Hynes, R.O. (1983). Complex regulation of fibronectin synthesis by cells in culture. Am. J. Physiol. 245:144-150.
  5. Van De Water, L., Destree, A.T. and Hynes, R.O. (1983). Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells. Science 220:201-204.
  6. Tamkun, J. and Hynes, R.O. (1983). Plasma fibronectin is synthesized and secreted by hepatocytes. J. Biol. Chem. 258:4641-4647.
  7. Wagner, D.D. and Hynes, R.O. (1982). Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles. Exp. Cell Res. 140:373-381.
  8. Hynes, R.O., Destree, A.T. and Wagner, D.D. (1982). Relationships between fibronectin actin and cell-substratum adhesion, in, "Organization of the Cytoplasm," Cold Spring Harbor Symp. Quant. Biol. 46:659-670.
  9. Van De Water, L., Schroeder, S., Crenshaw, E.B. and Hynes, R.O. (1981). Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin. J. Cell Biol. 90:32-39.
  10. Choi, M. and Hynes, R.O. (1979). Biosynthesis and processing of fibronectin in NIL.8 hamster cells. J. Biol. Chem., 254:12050-12055.
  11. Perkins, M.E., Ji, T.H. and Hynes, R.O. (1979). Crosslinking of fibronectin to proteoglycans at the cell surface. Cell 16:941-952.
  12. Mahdαvi, V. and Hynes, R.O. (1979). Proteolytic enzymes in normal and transformed cells. Biochim. Biophys. Acta 583:167-178.
  13. Hynes, R.O. and Destree, A.T. (1978). Relationships between fibronectin (LETS protein) and actin. Cell 15:875-886.
  14. Hynes, R.O., Ali, I.U., Destree, A.T., Mautner, V.M., Perkins, M.E. Senger, D.R., Wagner, D.D. and Smith, K. (1978). A large glycoprotein lost from the surfaces of transformed cells. Ann. N.Y. Acad. Sci. 312:317-342
  15. Mahdαvi, V. and Hynes, R.O. (1978). Effects of cocultivation with transformed cells on surface proteins of normal cells. Biochim. Biophys. Acta 542:191-208.
  16. Ali, I.U. and Hynes, R.O. (1978). Effects of LETS glycoprotein on cell motility. Cell 14:439-446.
  17. Ali, I.U. and Hynes, R.O. (1978). Role of disulfide bonds in the attachment and function of LETS glycoprotein at the cell surface. Biochem. Biophys. Acta 510:140-150.
  18. Dunham, J.S. and Hynes, R.O. (1978). Differences in the sulfated macromolecules synthesized by normal and transformed hamster fibroblasts. Biochim. Biophys. Acta 506:242-255.
  19. Hynes, R.O., Destree, A.T., Mautner, V.M. and Ali, I.U. (1977). Synthesis, secretion, and attachment of LETS glycoprotein in normal and transformed cells. J. Supramol. Struct. 7:397-408.
  20. Ali, I.U. and Hynes, R.O. (1977). Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts. Biochim. Biophys. Acta 471:16-24.
  21. Mautner, V.M. and Hynes, R.O. (1977). Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed fibroblasts. J. Cell Biol. 75:743-768.
  22. Hynes, R.O. and Destree, A.T. (1977). Extensive disulfide bonding at the mammalian cell surface. Proc.Natl.Acad.Sci. 74:2855-2859.
  23. Ali, I.U., Mautner, V.M., Lanza, R.P. and Hynes, R.O. (1977). Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell 11:115-126.
  24. Hynes, R.O., Destree, A.T. and Mautner, V.M. (1976). Spatial organization at the cell surface, in "Membranes and Neoplasia: New Approaches and Strategies", pp. 189-201. (V.T. Marchesi, ed.) Alan R. Liss, Inc., New York.
  25. Critchley, D.R., Wyke, J.A. and Hynes, R.O. (1976). Cell surface and metabolic labelling of the proteins of normal and transformed chicken cells. Biochim. Biophys. Acta 436:335-352.
  26. Pearlstein, R., Hynes, R.O., Franks, L.M. and Hemmings, V.J. (1976). Surface proteins and fibrinolytic activity of cultured mammalian cells. Cancer Res., 36:1475-1480.
  27. Hynes, R.O. and Pearlstein, E.S. (1976). Investigations of the possible role of proteases in altering surface proteins of virally transformed hamster fibroblasts. J. Supramol. Struc. 4:1-14
  28. Hynes, R.O., Martin, G.S., Shearer, M., Critchley, D.R. and Epstein, C.J. (1976). Viral transformation of rat myoblasts: effects on fusion and surface properties. Dev. Biol. 48:35-46.
  29. Hynes, R.O. and Wyke, J.A. (1975). Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus. Virology 64:492-504.
  30. Graham, J.M., Hynes, R.O., Davidson, E.A. and Bainton, D.F. (1975). The location of proteins labelled by the 125I-lactoperoxidase system in the NIL8 hamster fibroblast. Cell 4:353-365.
  31. Hynes, R.O. and Bye, J.M. (1974). Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell 3:113-120.
  32. Hynes, R.O. and Humphryes, K.C. (1974). Characterization of the external proteins of hamster fibroblasts. J. Cell Biol. 62:438-448.
  33. Hynes, R.O. (1973). Alteration of cell-surface proteins by viral transformation and by proteolysis. Proc. Natl. Acad. Sci. USA 70:3170-3174.

 

Fibronectins-Structure/function molecular biology
  1. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L.  (2008).  EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1.  J. Biol. Chem. 283: 2858-2870.
  2. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  3. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004). Direct test of potential roles of EIIIA and EIIIB alternatively spliced variants of fibronectin in physiological and tumor angiogenesis. Mol. Cell Bio. 19: 8662-8670.
  4. Hynes, R.O. (1999) The dynamic dialogue between cells and matrices: implications of fibronectin's elasticity. Proc. Natl. Acad. Sci. USA 96: 2588-2590
  5. Hynes, R.O. (1999). Fibronectins. in: Guidebook to the Extracellular Matrix, Anchor and Adhesion Proteins. 2nd Ed. Kreis, T. and Vale, R., eds. Sambrook and Tooze Publishers., Oxford University Press pp.422-425.
  6. Bloom, L., Ingham, K.C. and Hynes, R.O. (1999) Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol. Biol. Cell 10:1521-1536.
  7. Hedjran, F., Yeakley, J.M., Huh, G.S., Hynes, R.O., and Rosenfeld, M.G. (1997). Control of alternative splicing by distributed pentameric repeats. Proc. Natl. Acad. Sci. USA 94: 12343-12347.
  8. Huh, G.S. and Hynes, R.O. (1994). Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes and Devel. 8:1561-1574.
  9. Huh, G. and Hynes, R.O. (1993). Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol. Cell. Biol. 13:5301-5314.
  10. DeSimone, D.W., Norton, P.A. and Hynes, R.O. (1992). Expression and alternative splicing of Xenopus fibronectin mRNA. Dev. Biol. 149:357-369.
  11. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120 kDa protein. Cell Regulation 2:951-964.
  12. Guan, J.-L. and Hynes, R.O. (1990). Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor a4b1. Cell 60:51-63.
  13. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1990). Retroviral expression of alternatively spliced forms of rat fibronectin. J. Cell Biol. 110:833-847.
  14. Schwarzbauer, J.E., Mulligan, R.C. and Hynes, R.O. (1987). Efficient and stable expression of recombinant fibronectin polypeptides. Proc. Natl. Acad. Sci. USA. 84:754-758.
  15. Schwarzbauer, J.E., Patel, R.S., Fonda, D. and Hynes, R.O. (1987). Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J. 6:2673-2580
  16. Patel, R.S., Odermatt, E., Schwarzbauer, J.E. and Hynes, R.O. (1987). Organization of the rat fibronectin gene provides evidence for "exon shuffling" during evolution. EMBO J. 6:2565-2572.
  17. Paul, J.I., Schwarzbauer, J.E., Tamkun, J.W. and Hynes, R.O. (1986). Cell-type-specific fibronectin subunits generated by alternative splicing. J. Biol. Chem. 261:12258-12265.
  18. Odermatt, E., Tamkun, J.W. and Hynes, R.O. (1985). The repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation. Proc. Natl. Acad. Sci. USA. 82:6571-6575.
  19. Schwarzbauer, J.E., Paul, J.I. and Hynes, R.O. (1985). On the origin of species of fibronectin. Proc. Natl. Acad. Sci. USA, 81:1424-1428.
  20. Paul, J.I. and Hynes, R.O. (1984). Multiple fibronectin subunits and their posttranslational modifications. J. Biol. Chem. 21:13477-13487.
  21. Tamkun, J.W., Schwarzbauer, J.E. and Hynes, R.O. (1984). A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc. Natl. Acad. Sci. USA 81:5140-5144.
  22. Schwarzbauer, J.E., Tamkun, J.W., Lemischka, I.R. and Hynes, R.O. (1983). Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell 35:421-431.
  23. Lahαv, J., Schwartz, M.A. and Hynes, R.O. (1982). Analysis of platelet adhesion using a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31:253-262
  24. Bing, D.H., Almeda, S., Isliker, H., Lahαv, J. and Hynes, R.O. (1982). Fibronectin binds to the Clq component of complement. Proc. Natl. Acad. Sci. USA 79:4198-4201.
  25. Wagner, D.D., Ivatt, R., Destree, A.T. and Hynes, R.O. (1981). Similarities and differences between the fibronectins of normal and transformed hamster cells. J. Biol. Chem. 256:11708-11715.
  26. Atherton, B.T. and Hynes, R.O. (1981). A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell 25:133-141.
  27. Wagner, D.D. and Hynes, R.O. (1980). Topological arrangement of the major structural features of fibronectin. J. Biol. Chem. 255:4304-4312.
  28. Wagner, D.D. and Hynes, R.O. (1979). Domain structure of fibronectin and its relation to function. J. Biol. Chem. 254:6746-6754.
Cadherins
  1. Radice, G., Ferreira-Cornwell, M.C., Robinson, S.D., Rayburn, H., Chodosh, L.A., Takeichi, M. and Hynes, R.O. (1997) Precocious mammary gland development in P-cadherin-deficient mice. J.Cell Biol. 139: 1025-1032.
  2. Charlton, C.A., Mohler, W.A., Radice, G.L., Hynes, R.O. and Blau, H.M. (1997). Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J. Cell Biol. 138:331-336.
  3. Radice, G., Rayburn, H., Matsunami, H., Knudsen, K. A., Takeichi, M. and Hynes, R.O. (1997) Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. 181: 64-78.
  4. Hynes, R.O. (1992) Specificity of cell adhesion in development: the cadherin superfamily. Curr. Opin. Genetics and Devel. 2:621-624.
  5. Geiger, B., Salomon, D., Takeichi, M. and Hynes, R.O. (1992). A chimeric N-cadherin / b1-integrin receptor interacts with both intercellular and cell-matrix adhesions. J. Cell Sci. 103:943-951.
  6. Salomon, D., Ayalon, O., Patel-King, R., Hynes, R.O. and Geiger, B. (1992). Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J. Cell Sci. 102:7-17.
  7. Geiger, B., Volberg, T., Ginsberg, D., Bitzur, S., Sabanay, I. and Hynes, R.O. (1990). Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin. J. Cell Science 97:607-614.
Selectins
  1. Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007).  Importance of donor- and recipient-derived selectins in cardiac allograft rejection.  J. Am. Soc. Nephrol. 18:2929-2936
  2. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins. Proc. Natl. Acad. Sci. USA 101: 763-768.
  3. Borsig, L., Wong, R., Hynes, R.O., Varki, N.M. and Varki, A. (2002). Synergistic effect of L- and P-selectin in facilitating tumor metastasis in a syngeneic system involving non-mucin ligands - further evidence for selectin inhibition as a mode of heparin action. Proc. Natl. Acad. Sci. USA 99: 2193-2198.
  4. Niederman, R., Westernoff, T., Lee, C., Mark, L.L., Kawashima, N., Ullman-Culleré, M., Dewhirst, F.E., Paster, B.J., Wagner, D.D., Mayadas, T., Hynes, R.O. and Stashenko, P. (2001). Infection-mediated early onset periodontal disease in P-/E-selectin knockout mice. J.Clin. Periodontol. 28:569-575.
  5. Robinson, S.D., Frenette, P.S., Rayburn, H., Cummiskey, M., Ullman-Cullere, M., Wagner, D.D. and Hynes, R.O. (1999). Multiple targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc. Natl. Acad. Sci. USA 96: 11452-11457.
  6. Kawashima, N., Neiderman, R., Ullman-Culleré, M., Hynes, R.O. and Stashenko, P. (1999). Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice. Immunol. 97: 117-123.
  7. Robert, C., Fuhlbrigge, R.C., Kieffer, J.D., Ayehunie, S., Ruprecht, R., Hynes, R.O., Cheng, G., Wong, T.H., Grabbe, S., von Andrian, U.H. and Kupper, T.S. (1999) Interaction of dendritic cells with skin endothelium: new perspective on immunosurveillance. J. Exp. Med.. 189: 627-635.
  8. Hartwell, D.W., Butterfield, C.E., Frenette, P.S., Kenyon, B.M., Hynes, R.O., Folkman, J. and Wagner, D.D. (1998). Angiogenesis in P-selectin- and E-selectin-deficient mice. Microcirculation, 5: 173-178.
  9. Hartwell, D.W., Mayadas, T.N., Frenette, P.S., Berger, G., Rayburn, H., Hynes, R.O. and Wagner, D.D. (1998) Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory processes. J. Cell Biol. 143: 1129-1141.
  10. Homeister, J.W., Zhang, M., Frenette, P.S., Hynes, R.O., Wagner, D.D., Lowe, J.B. and Marks, R.M. (1998). Overlapping functions of E- and P-selectin in neutrophil accumulation during acute dermal inflammation. Blood 92:2345-2352.
  11. DeMora, F., Williams, C.M.M., Frenette, P.S., Wagner, D.D., Hynes, R.O. and Galli, S.J. (1998). P- and E-selectin are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. Lab. Invest. 78:497-505.
  12. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D. and von Andrian, U.H. (1998). Stem cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and VCAM-1. J. Exp. Med. 188:465-474.
  13. Seiler, K.P., Ma, Y., Weis, J.H., Frenette, P.S., Hynes, R.O., Wagner, D.D. and Weis, J.J. (1998). E and P selectins are not required for resistance to severe murine lyme arthritis. Infection and Immunity 66:4557-4559.
  14. Dong, Z.M., Chapman, S.M., Brown, A.A., Frenette, P.S., Hynes, R.O. and Wagner, D.D. (1998). The combined role of P- and E-selectins in atherosclerosis. . J. Clin. Invest. 102: 145-152.
  15. Frenette, P.S., Moyna, C., Hartwell, D.W., Lowe, J.B., Hynes, R.O. and Wagner, D.D. (1998). Platelet-endothelial interactions in inflamed mesenteric venules. Blood, 91: 1318-1324.
  16. Subramaniam, M., Saffaripour, S., Van De Water, L., Frenette, P.S., Mayadas, T.N., Hynes, R.O., and Wagner, D.D. (1997). Role of endothelial selectins in wound repair. Am. J. Path. 150: 1701-1709.
  17. Johnson, R.C., Chapman, S.M., Dong, Z.M., Ordovas, J.M., Mayadas, T.N., Herz, J.I., Hynes, R.O., Schaefer, E.J. and Wagner, D.D. (1997). Absence of P-selectin delays fatty streak formation in mice. J. Clin. Invest., 99: 1037-1043
  18. Mayadas, T.N., Mendrick, D.L., Brady, H.R., Tang, T., Papayianni, A., Assmann, K.J.M., Wagner, D.D., Hynes, R.O. and Cotran, R.S. (1996). Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Kidney Internatl., 49:1342-1349.
  19. Tang, T., Frenette, P.S., Hynes, R.O., Wagner, D.D. and Mayadas, T.N. (1996). Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J. Clin. Invest. 97:2485-2490.
  20. Subramaniam, M., Frenette, P.S., Saffaripour, S., Johnson, R.C., Hynes, R.O. and Wagner, D.D. (1996). Defects in hemostasis in P-selectin-deficient mice Blood 87:1238-1242.
  21. Yamada, S., Mayadas, T.N., Yuan, F., Wagner, D.D., Hynes, R.O., Melder, R.J. and Jain, R.K. (1996). Rolling in P-selectin deficient mice is reduced but not eliminated in the dorsal skin. Blood 86: 3487-3492.
  22. Pinsky, D.J., Naka, Y., Liao, H., Oz, M.C. , Wagner, D.D., Mayadas, T., Johnson, R., Hynes, R.O., Heath, M., Lawson, C.A. and Stern, D.M. (1996). Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies: a mechanism for rapid neutrophil recruitment following cardiac preservation. J. Clin. Invest. 97:493-500.
  23. Frenette, P.S., Mayadas, T.N., Rayburn, H., Hynes, R.O. and Wagner, D.D. (1996) Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84: 563-574
  24. Frenette, P.S., Johnson, R.C., Hynes, R.O. and Wagner, D.D. (1995). Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc. Natl. Acad. Sci. USA: 92:7450-7454.
  25. Johnson, R.C., Mayadas, T.N., Frenette, P,S., Mebius, R.E., Subramaniam, M., Lacasce, A., Hynes, R.O. and Wagner, D.W. (1995). Blood cell dynamics in P-selectin-deficient mice. Blood 86:1106-1114.
  26. Subramaniam, M., Saffaripour, S., Watson, S.R., Mayadas, T.N., Hynes, R.O. and Wagner, D.D. (1995). Reduced recruitment of inflammatory cells in a contact hypersensitivy response in P-selectin-deficient mice. J. Exp. Med. 181 : 2277-2282
  27. Mayadas, T.N., Johnson R.C., Rayburn, H. , Hynes, R.O. and Wagner, D.D. (1993) Leukocyte rolling and extrαvasation are severely compromised in P-selectin-deficient mice. Cell 74:541-554.

 

Integrins-in vivo

 

  1. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008).  Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.  Am. J. Path. 172:1740-1747.
  2. Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007). b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transplant. 7: 1080-1090.
  3. Lacy-Hulbert, A., Smith, A.M., Tissire, H., Barry, M., Crowley, D., Bronson, R.T., Roes, J.T., Savill, J.S. and Hynes, R.O.  (2007).  Ulcerative colitis and impaired clearance of apoptotic cells induced by loss of myeloid av integrins. Proc. Natl. Acad. Sci. USA 104: 15823-15828.
  4. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  5. McCarty, J.H. and Hynes, R.O. (2006).  Endothelial cell integrins. in The Endothelium: A Comprehensive Reference.  Ed. William C. Aird.  Cambridge University Press, New York.
  6. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  7. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
  8. Staquet, M-J., Couble, M-L., Romeas, A., Connolly, M., Magloire, H., Hynes, R.O., Clezardin, P., Bleicher, F. and Farges, J-C.  (2006).  Expression and localisation of av integrins in human odontoblasts.    Cell and Tissue Res. 323:457-463.
  9. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  10. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).   A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.        Blood 107:2976-2983.
  11. McCarty, J.H., Cook, A. and Hynes, R.O. (2005). A novel interaction between avb8 integrin and band 4.1B via a highly conserved region of the band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. USA. 102:13479-13483.
  12. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D., Savill, J., Roes, J. and Hynes, R.O. (2005). Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 132: 165-176.
  13. Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Lacy-Hulbert, A., Hynes, R.O. and Hodivala-Dilke, K. (2005). Accelerated re-epithelialisation in β3-integrin-deficient mice: A novel mechanism for the regulation of TGFβ1-mediated signalling by β3-integrin. Nat. Med. 11: 167-174 .
  14. Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
  15. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  16. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins. Proc. Natl. Acad. Sci. USA 101: 763-768.
  17. Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Xiao, Q. and Hodivala-Dilke, K. (2003). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.
  18. Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003). Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis αVβ3 integrin. Cancer Cell 3: 589-601.
  19. McCarty, J.H., Monahan-Earley, R.A., Dvorak, A.M., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Wolburg, H., Bader, B.L., Dvorak, H.F. and Hynes, R.O. (2002). Defective associations between blood vessels and developing neuronal parenchyma lead to cerebral hemorrhage in mice lacking αv integrins. Mol. Cell. Biol. 22: 7667-7677.
  20. Francis, S.E., Goh, K.L., Hodivala-Dilke, K., Bader, B.L., Stark, M., Davidson, D. and Hynes, R.O. (2002). Central roles of a5b1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis and Vasc. Biol. 22: 927-933.
  21. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002). αvβ3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
  22. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
  23. DiPersio, C.M., Trevithick, J.E. and Hynes, R.O. (2001). Functional comparison of the a3A and a3B cytoplasmic domain variants of the chicken a3 integrin subunit. Exp. Cell Res. 268: 45-60.
  24. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
  25. Haack, H. and Hynes, R.O. (2001). Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Devel. Biol. 233:38-55.
  26. DiPersio, C.M., van der Neut, R., Georges-Labouesse, E., Kreidberg, J.A., Sonnenberg, A. and Hynes, R.O. (2000) a3b1 and a6b4 integrin receptors for laminin-5 are not required for epidermal morphogenesis during skin development. J. Cell Sci. 113: 3051-3062.
  27. Arroyo, A.G., Taverna, D.T., Whittaker, C., Strauch, U., Bader, B.L., Rayburn, H., Crowley, D, Parker, C. and Hynes, R.O. (2000). In vivo roles of a4 integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for a5, αv and a4 integrins. J. Immunology 165: 4667-4675.
  28. McHugh, K., Hodivala-Dilke, K., Zheng, M.H., Namba, N., Lam, J., Novack, D., Feng, X., Ross, F.P., Hynes, R.O. and Teitelbaum, S.L. (2000). Mice lacking β3 integrins are osteosclerotic due to dysfunctional osteoclasts. J. Clin. Invest. 105: 433-440.
  29. Arroyo, A.G., Yang, J.T., Rayburn, H. and Hynes, R.O. (1999). a4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 11: 555-566.
  30. Yang, J.T., Bader, B.L., Kreidberg, J.A., Ullman-Culleré, M., Trevithick, J.E. and Hynes, R.O. (1999). Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Devel. Biol. 215: 264-277.
  31. Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B.L., Hynes. R.O., Zhang, Y., Manova, K., and Benezra, R. (1999). Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumor xenografts. Nature 401: 670-677.
  32. Anderson, R., Fässler, R., Georges-Labouesse, E., Hynes, R.O., Bader, B., Kreidberg, J.A., Schaible, K., Heasman, J. and Wylie, C. (1999). Mouse primordial germ cells lacking b1 integrins enter the germ line but fail to migrate normally to the gonads. Development 126: 1655-1664.
  33. Hodivala-Dilke, K.M., McHugh, K., Tsakiris, D.A., Rayburn, H., Crowley, D. , Ullman-Culleré, M., Ross, F.P., Coller, B.S., Teitelbaum, S. and Hynes, R.O. (1999). β3-integrin-deficient mice: a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J.Clin. Invest. 103: 229-238.
  34. Taverna, D., Disatnik, M.H., Rayburn, H., Bronson, R.T., Rando, T.A., Yang, J.T. and Hynes, R.O. (1998). Dystrophic muscle in mice chimeric for expression of α5 integrin. . J. Cell Biol. 143: 849-859.
  35. Taverna, D., Ullman-Culleré, M., Rayburn, H., Bronson, R.T. and Hynes, R.O. (1998). A test of the role of α5 integrin/fibronectin interactions in tumorigenesis. Cancer Res., 58: 848-853.
  36. Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O. (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all αv integrins. Cell 95: 507-519.
  37. Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
  38. Goh, K.L., Yang, J.T. and Hynes, R.O. (1997) Mesodermal defects and cranial neural crest apoptosis in a5 integrin-null embryos Development 124:4309-4319.
  39. DiPersio, C. M., Hodivala-Dilke, K.M., Jaenisch, R. Kreidberg, J.A., and Hynes, R. O. (1997). α3β1 integrin is required for normal development of the epidermal basement membrane J. Cell Biol., 137: 729-742
  40. Yang, J. T and Hynes, R. O. (1996) Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by αv integrins. Mol. Biol. of the Cell 7:1737-1748.
  41. Yang, J. T., Rando, T., Rayburn, H.. Blau, H. and Hynes, R. (1996) Genetic analysis of a4 integrin functions in the development of mouse skeletal muscle. J.Cell Biol. 135:829-835.
  42. Arroyo, A. G., Yang, J. T., Rayburn, H. and Hynes, R. O. (1996) Differential requirements for a4 integrins during fetal and adult hematopoiesis. Cell 85: 997-1008.
  43. Stepp, M.A., Urry, L.A. and Hynes, R.O. (1994). Expression of a4 integrin mRNA and protein and fibronectin in the early chicken embryo. Cell Adhes. and Commun. 2:359-375.
  44. Yang, J.T., Rayburn, H. and Hynes , R. O. (1995). Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 121:549-560.
  45. Yang, J.T., Rayburn, H. and Hynes, R.O. (1993) Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119:1093-1105.

 

Integrins-cellular and molecular
  1. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  2. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007).  a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
  3. Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007).  b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transpl. 7: 1080-1090.
  4. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  5. McCarty, J.H. and Hynes, R.O. (2006).  Endothelial cell integrins. in The Endothelium: A Comprehensive Reference.  Ed. William C. Aird.  Cambridge University Press, New York.
  6. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  7. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.        Blood 107:2976-2983.
  8. Taverna, D., Crowley, D., Connolly, M., Bronson, R.T. and Hynes, R.O.  (2005). A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas.  Cancer Res. 65: 10324-10329.
  9. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., and Wilcox, D.A.  (2005). Therapeutic expression of the platelet-specific integrin, aIIbb3, in a murine model for Glanzmann thrombasthenia. Blood. 106:2671-2679.
  10. Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Hynes, R.O., Lacy-Hulbert, A. and Hodivala-Dilke, K.  (2005). Accelerated re-epithelialisation in b3-integrin-deficient mice is associated with enhanced TGFb1-mediated signaling. Nat. Med. 11: 167-174.
  11. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D.H., Savill, J. and Hynes, R.O.  (2005).  Selective ablation of av integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.  Development 132:165-176.
  12. McCarty, J.H., Cook, A. and Hynes, R.O. (2005). A novel interaction between αvβ8 integrin and band 4.1B via a highly conserved region of the band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. USA. 102:13479-13483.
  13. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased tumor growth in mice null for b3- or b3/b5-integrins or selectins. . Proc. Natl. Acad. Sci. USA. 101: 763-768.
  14. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  15. Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
  16. Hynes, R.O. (2003). Changing Partners Science: Vol. 300: 755-756 (in Perspectives).
  17. Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O.  and  Leong, J.M  (2003).  Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis.        Blood . 102:2843-50
  18. Hynes, R.O. (2002) Integrins: bi-directional, allosteric, signaling machines. Cell. Vol. 110: 673-687.
  19. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002). αvbeta;3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
  20. DiPersio, C.M., Trevithick, J.E. and Hynes, R.O. (2001) Functional comparison of the a3A and a3B cytoplasmic domain variants of the chicken a3 integrin subunit. Exp. Cell Res. 268: 45-60.
  21. DiPersio, C.M., Shao, M., Di Costanzo, L., Kreidberg, J.A., and Hynes, R.O. (2000). Mouse keratinocytes immortalized with large T antigen acquire a3b1integrin-dependent secretion of MMP-9/Gelatinase B. J. Cell Sci. 113: 2909-2921.
  22. Saoncella, S., Echtermeyer, F., Denhez, F., Nowlen, J.K., Mosher , D.F., Robinson, S.D., Hynes, R.O. and Goetinck, P.F. (1999). Syndecan-4 signals cooperatively with integrins, in a Rho-dependent manner, in the assembly of focal adhesions and actin stress fibers in fibronectin-null fibroblasts. Proc. Natl. Acad. Sci. USA 96: 2805-2810.
  23. Hodivala-Dilke, K.M, DiPersio, C. M., Kreidberg, J.A., and Hynes, R. O. (1998). Novel roles for a3b1 integrin as a regulator of cytoskeletal asssmbly and as a transdominant inhibitor of integrin receptor function in mouse keratinocytes. J. Cell Biol. 142: 1357-1369.
  24. Clark, E.A., King,W.G., Brugge, J.S., Symons, M. and Hynes, R.O. (1998) Integrin-mediated signals regulated by members of the Rho family of GTPases. J. Cell Biol. 142: 573-586.
  25. DiPersio, C. M., Hodivala-Dilke, K.M., Jaenisch, R. Kreidberg, J.A., and Hynes, R. O. (1997). a3b1 integrin is required for normal development of the epidermal basement membrane J. Cell Biol., 137: 729-742
  26. Clark, E. A. and Hynes, R.O. (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem. 271: 14814-14818.
  27. DiPersio, C.M., Shah, S. and Hynes, R.O. (1995). a3Ab1 integrin localizes to focal contacts in response to diverse extracellular ligands. J. Cell Sci. 108:2321-2336.
  28. Hynes, R.O. (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69:11-25.
  29. Hynes, R.O., and Plantefaber, L.C. (1991). Integrin receptors for extracellular matrix and their involvement in oncogenic transformation. In Origins of Human Cancer: A Comprehensive Review (Brugge, J., Curran, T., Harlow, E and McCormick, F.). Plainview, NY: Cold Spring Harbor. pp. 293-307.
  30. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120 kDa protein. Cell Regulation 2:951-964.
  31. Marcantonio, E.E., Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1990). Mapping of the functional determinants of the integrin b1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation 1:597-604.
  32. Solowska, J., Guan, J.-L., Marcantonio, E.E., Trevithick, J.E., Buck, C.A. and Hynes, R.O. (1989). Expression of normal and mutant αvian integrin subunits in rodent cells. J. Cell Biol. 109:853-861.
  33. Plantefaber, L.C. and Hynes, R.O. (1989). Changes in integrin receptors on oncogenically transformed cells. Cell 56:281-290.
  34. Hynes, R.O., Marcantonio, E.E., Stepp, M.A., Urry, L.A. and Yee, G. (1989). Integrin heterodimer and fibronectin receptor complexity in αvian and mammalian cells. J. Cell Biol. 109:409-420.
  35. Marcantonio, E.E. and Hynes, R.O. (1988). Antibodies to the conserved cytoplasmic domain of the integrin b1 subunit react with proteins in vertebrates, invertebrates and fungi. J. Cell Biol. 106:1765-1772.
  36. DeSimone, D.W. and Hynes, R.O. (1988). Xenopus integrins: structural conservation and evolutionary divergence of integrin b subunits. J. Biol. Chem. 263:5333-5340.
  37. Hynes, R.O. (1987). Integrins: a family of cell surface receptors. Cell, 48:549-554.
  38. Tamkun, J.W., DeSimone, D.W., Fonda, D., Patel, R.S., Buck, C., Horwitz, A.F. and Hynes, R.O. (1986). Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 46:271-282.
  39. Gardner, J.M. and Hynes, R.O. (1985). Interaction of fibronectin with its receptor on platelets. Cell 42:439-448.
Talin & Layilin
  1. Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. (2005). Exp. Cell Res. 308: 177-187.
  2. Bono, P., Rubin, K.R., Higgins, J.M.G. and Hynes, R.O. (2001). Layilin, a novel integral membrane protein, is a hyaluronan receptor. Mol. Biol. Cell 12: 891-900.
  3. Calderwood, D.A., Zent, R., Rees, D.J.G., Hynes, R.O. and Ginsberg, M.H. (1999). The talin head domain binds to integrin b subunit cytoplasmic tails and regulates integrin activation. J.Biol. Chem. 274: 28071-28074.
  4. Borowsky, M.L. and Hynes, R.O. (1998). Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J. Cell Biol. 143: 429-442.
  5. Hemmings, L., Rees, D.J.G., Ohanian, V., Bolton, S.J., Gilmore, A.P., Patel, B., Priddle, H., Trevithick, J.E., Hynes, R.O. and Critchley, D.R. (1996) Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J. Cell Sci., 109: 2715-2726.
  6. McLachlan, A.D., Stewart, M., Hynes, R.O. and Rees, D.J.G. (1994). Analysis of repeated motifs in the talin rod. J. Mol. Biol. 235:1278-1290.
  7. Gilmore, A.P., Wood, C., Ohanian, V., Jackson, P., Patel, B., Rees, D.J.G., Hynes, R.O. and Critchley, D.R. (1993). The cytoskeletal protein talin contains at least two distinct vinculin binding domains. J. Cell Biol. 122:337-347.
  8. Rees, D.J.G. Ades, S.A., Singer, S.J. and Hynes, R.O. (1990). Sequence and domain organization of talin, a member of a family of submembranous cytoskeletal proteins. Nature 347: 685-689.

 

Thrombospondin
  1. Lawler, J., Miao, W.M., Duquette, M., Bouck, N., Bronson, R.T. and Hynes, R.O. (2001). Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am.J. Path. 159: 1949-1956
  2. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J. and Iruela-Arispe, M.L. (2001). Thrombospondin-1 suppresses spontaneous tumor growth and angiogenesis and inhibits activation of matrix metalloprotease-9 and mobilisation of VEGF. Proc. Natl. Acad. Sci. USA 98: 12485-12490.
  3. Crawford, S.E., Stellmach, V., Murphy-Ullrich, J., Ribeiro, S.F., Lawler, J., Hynes, R.O., Boivin, G.P., and Bouck, N. (1998). Thrombospondin is an activator of TGF- b in vivo. Cell 93: 1158-1170.
  4. Lawler, J., Sunday, M., Thibert, V., Duquette, M., George, E.L., Rayburn, H. and Hynes, R.O. (1998). Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J. Clin. Invest. 101:982-992.
  5. Stellmach, V., Volpert, O.V., Crawford, S.E., Lawler, J., Hynes, R.O. and Bouck, N. (1997) Tumor suppressor genes and angiogenesis: the role of p53 in fibroblasts. Eur. J. Cancer 32A: 2394-2400.
  6. Lawler, J. and Hynes, R.O. (1989). An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood 74:2022-2027.
    Lawler, J., Weinstein, R. and Hynes, R.O. (1988). Cell attachment to thrombospondin: the role of Arg-Gly-Asp, calcium and integrin receptors. J. Cell Biol. 107:2351-2361.
  7. Lawler, J. and Hynes, R.O. (1987). Structural Organization of the Thrombospondin Molecule. in Seminars in Thrombosis and Hemostasis. 13:245-253. (Thieme Medical Publishers, Inc. New York, NY).
  8. Lawler, J. and Hynes, R.O. (1986). The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J. Cell Biol. 103:1635-1648.
  9. Lahαv, J., Schwartz, M.A. and Hynes, R.O. (1982). Analysis of platelet adhesion using a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31:253-262.
Drosophilia
  1. Hobert, O., Hutter, H. and Hynes, R.O. (2004). The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster. Development 131:2237-2238.
  2. Wheeler, G.N. and Hynes, R.O. (2001). The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila. Gene 262: 291-299.
  3. Hynes, R.O. and Zhao, Q. (2000). The evolution of cell adhesion. J. Cell Bio. 150: F89-F95.
  4. Rubin, G.M. et al. (2000). Comparative genomics of the eukaryotes. Science 287:2204-2215.
  5. Fox, G.L., Rebay, I. and Hynes, R.O. (1999). Expression of Dfak56, a Dsosophila homologue of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc. Natl. Acad. Sci. USA 96: 14978-14983.
  6. Stark, K.A., Yee, G.H., Roote, C.E., Williams, E.L., Zusman, S. and Hynes, R.O. (1997) A novel alpha integrin subunit associates with bPS and functions in tissue morphogenesis and movement during Drosophila development. Development 124:4583-4594.
  7. Gotwals, P. Paine-Saunders, S., Stark, K., and Hynes, R. O. (1994). Drosophila integrins and their ligands. Curr. Opin. in Cell Biol. 6:734-739.
  8. Gotwals, P.J., Fessler, L.I., Wehrli, M. and Hynes, R.O. (1994). Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proc. Natl. Acad. Sci. USA 91:11447-11451.
  9. Spring, J., Paine-Saunders, S., Hynes, R.O. and Bernfield, M. (1994). Drosophila syndecan: a heparan sulfate proteoglycan with a cytoplasmic domain highly conserved in the vertebrate syndecan family. Proc. Natl. Acad. Sci. USA 91:3334-3338.
  10. Grinblat, Y., Zusman, S., Yee, G., Hynes, R.O. and Kafatos, F.C. (1994). Functions of the cytoplasmic domain of the bPS integrin during Drosophila development. Development 120:91-102.
  11. Zusman, S., Grinblat, Y.,Yee, G., Kafatos, F.C.and Hynes, R.O. (1993). Functions of PS integrins during Drosophila development. Development 118:737-751.
  12. Yee, G. H. and Hynes, R.O. (1993). A novel, tissue-specific integrin subunit, bn, expressed in the midgut of Drosophila melanogaster. Development 118:845-858.
  13. Zusman, S., Patel-King, R.S., ffrench-Constant, C. and Hynes, R.O. (1990). Requirements for integrins during Drosophila development. Development 108:391-402
Miscellaneous
  1. Hynes R. (2007).  Reply to 'UK set to reverse stance on research with chimeras'. Nat Med. 13:1133.
  2. Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007).  b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transpl. 7: 1080-1090.
  3. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006).  The echinoderm adhesome.  Dev. Biol. 300: 252-266.
  4. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006).  The echinoderm adhesome.  Dev. Biol. 300: 252-266.
  5. Sea Urchin Genome Sequencing Consortium, (2006). The genome of the sea urchin Strongylocentrotus purpuratus.  Science 314:941-952.
  6. Staquet, M-J., Couble, M-L., Romeas, A., Connolly, M., Magloire, H., Hynes, R.O., Clezardin, P., Bleicher, F. and Farges, J-C.  (2006).  Expression and localisation of av integrins in human odontoblasts.    Cell and Tissue Res. 323:457-463.
  7. Moreno J.D. and Hynes, R.O. (2005).  Guidelines for human embryonic stem cell research.  Nat Biotechnol. 23:793-794.
  8. Lindenbach B.D., Evans, M.J., Syder, A.J., Wolk, B., Tellinghuisen, T.L., Liu, C.C., Maruyama, T., Hynes, R.O., Burton,, D.R., McKeating J.A. and Rice, C.M.  (2005).  Complete replication of Hepatitis C Virus in cell culture.  Science 309; 623-626.
  9. Bono, P., Cordero, E., Johnson, K., Borowsky, M.L., Ramesh,V., Jacks, T., and Hynes, R.O.  (2005).  Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Exp. Cell Res. 308;177-187.
  10. Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Hynes, R.O., Lacy-Hulbert, A. and Hodivala-Dilke, K.  (2005). Accelerated re-epithelialisation in b3-integrin-deficient mice is associated with enhanced TGFb1-mediated signaling. Nat. Med. 11: 167-174.
  11. Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O.  and  Leong, J.M  (2003).  Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis.        Blood . 102:2843-50.
  12. Hobert, O., Hutter, H. and Hynes, R.O. (2004). The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster. Development 131:2237-2238.
  13. Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. Complete Replication of Hepatitis C Virus in Cell Culture. Science. 309: 623-626.
  14. Hobert, O., Hutter, H. and Hynes, R.O. (2004). The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster. Development 131:2237-2238.
  15. Whittaker, C.A. and Hynes, R.O. (2002) Distribution and evolution of the von Willebrand/Integrin A domain: a widely dispersed domain with roles in cell adhesion and elsewhere. Mol. Biol. Cell. Vol. 13, Issue 10: 3369-3387.
  16. Alcamo, E., Hacohen, N., Rennert, P.D., Hynes, R.O. and Baltimore, D. (2002). Requirement for the NF-kB family member RelA in the development of secondary lymphoid organs. J. Exp. Med. 195:233-244.
  17. Zhu, G.Z., Miller, B.J., Boucheix, C., Rubenstein, E., Liu, C.C., Hynes, R.O., Myles, D.G. and Primakoff, P. (2002). Residues SFQ (173-175) in the largest extracellular loop of CD9 are required for gamete fusion. Development 129: 1995-2002.
  18. Bono, P., Rubin, K.R., Higgins, J.M.G. and Hynes, R.O. (2001). Layilin, a novel integral membrane protein, is a hyaluronin receptor. Mol. Biol. Cell 12: 891-900.
  19. Alcamo. E., Mizgerd, J.P., Horwitz, B.H., Bronson, R., Beg, A., Scott, M., Doerschuk, C.M., Hynes, R.O. and Baltimore, D. (2001). Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappaB in leukocyte recruitment. J. Immunol. 167: 1592-1600.
  20. Clark, E.A., Golub, T.R., Lander, E. and Hynes, R.O. (2000) Genomic analysis of metastasis reveals an essential role for rhoC. . Nature, 406: 532-535.
  21. Cowin, P., Kapprell, H.-P., Franke, W.W., Tamkun, J.W. and Hynes, R.O. (1986). Plakoglobin: a plaque protein common to different kinds of intercellular adhering junctions. Cell 46:1063-1073.
  22. Hynes, R.O., Patel, R. and Miller, R.H. (1986). Migration of neuroblasts along preexisting axonal tracts during prenatal cerebellar development. J. Neuroscience 6:867-876.
  23. Schwartz, M.A., Das, O.P. and Hynes, R.O. (1982). A new radioactive crosslinking reagent for studying the interactions of proteins. J. Biol. Chem. 257:2343-2349.
  24. Bing, D.H., Almeda, S., Isliker, H., Lahαv, J. and Hynes, R.O. (1982). Fibronectin binds to the Clq component of complement. Proc. Natl. Acad. Sci. USA 79:4198-4201.
  25. Senger D.R., Wirth, D.F., Bryant, C. and Hynes, R.O. (1980). Transformation-specific secreted proteins in "Viral Oncogenes", Cold Spring Harbor Symposia 44:651-657.
  26. Senger, D.R., Wirth, D.F. and Hynes, R.O. (l980). Transformation-specific secreted phosphoproteins. Nature 286:619-621.
  27. Senger, D.R., Wirth, D.F. and Hynes, R.O. (1979). Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 16:885-894.
  28. Senger, D.R. and Hynes, R.O. (1978). C3 component of complement secreted by established cell lines. Cell 15:375-384.
  29. Hynes, R.O. and Destree, A.T. (1978). 10 nm filaments in normal and transformed cells. Cell 13:151-163.
  30. Smart, J.E. and Hynes, R.O. (1974). Developmentally regulated cell surface alterations in Dictyostelium discoideum. Nature 251:319-321.