Recent Publications

  1. Labelle M, Hynes RO. The Initial Hours of Metastasis: The Importance of Cooperative Host–Tumor Cell Interactions during Hematogenous Dissemination. Cancer Discov. 2012 Dec;2(12):1091-9. doi: 10.1158/2159-8290.CD-12-0329. Epub 2012 Nov 19. PMCID: PMC3540992
  2. Reticker-Flynn, N.E., Malta, D.F.B., Winslow, M.M., Lamar, J.M., Xu, M.J., Underhill, G.H., Hynes, R.O., Jacks, T.E., and Bhatia, S.N. (2012). A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications 3, 1122. PMID:23047680
  3. Gupton,SL, Riquelme, D, Hughes-Alford, SK, Tadros, J, Rudina, SS, Hynes, RO, Lauffenburger, D. and Gertler, FB. (2012). Mena binds α5 integrin directly and modulates α5β1 function. J. Cell Biol. 198(4):657-676. PMCID:PMC3514034
  4. Lamar, JM, Stern, P., Liu, H., Schindler, JW, Jiang, Z. and Hynes, RO. (2012). The Hippo pathway target, YAP, promotes metastasis through its TEAD interaction domain. Proc. Natl. Acad. Sci. USA, [Epub ahead of print, Aug 13, 2012]. PMCID:PMC3443162
  5. Naba A, Hoersch S, Hynes RO. (2012) Towards definition of an ECM parts list: An advance on GO categories. Matrix Biol. 2012. Sep;31(7-8):371-2. doi: 10.1016/j.matbio.2012.11.008.
  6. Li, L., Welser-Alves, J.V., van der Flier, A., Boroujerdi, A., Hynes, R.O. and Milner, R. (2012). An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp. Neurol. [Epub ahead of print, Jun 18, 2012]. PMID:22721769
  7. Hynes, R.O. (2012). The Evolution of Metazoan Extracellular Matrix. J.Cell Biol. 196(6): 671-679. PMCID: PMC3308698
  8. Naba, A., Clauser, K.R., Hoersch, S., Liu, H., Carr, S.A. and Hynes, R.O. (2012). The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics. 11(4): M111.014647. Published online Dec. 9, 2011. PMCID: PMC3322572
  9. Bergmeier, W., and Hynes, R.O. (2012). Extracellular Matrix Proteins in Hemostasis and Thrombosis. In Extracellular Matrix Biology (eds. R.O. Hynes and K.M. Yamada). Cold Spring Harb Perspect Biol 3:a005132. Published online September 21, 2011. doi:10.1101/cshperspect.a005132.
  10. Hynes, R.O., and Naba, A. (2012). Overview of the Matrisome—An Inventory of Extracellular Matrix Constituents and Functions. In Extracellular Matrix Biology (eds. R.O. Hynes and K.M. Yamada). Cold Spring Harb Perspect Biol 3: a004903. Published online September 21, 2011. doi:10.1101/cshperspect.a004903
  11. Hynes, R.O. and Yamada, K.M. (2012). Editors. Extracellular Matrix Biology. Cold Spring Harbor Laboratory Press.
  12. Hynes, R.O. (2011). Metastatic cells will take any help they can get. Cancer Cell 20: 689-690. doi:10.1016/j.ccr.2011.11.022. PMCID: PMC3462586.
  13. Labelle M., Begum S., and Hynes R.O. (2011). Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. Cancer Cell 20: 576-590. PMCID: PMC3487108. doi:10.1016/j.ccr.2011.09.009
  14. Stenzel, D., Lundkvist, A., Sauvaget, D., Busse, M., Graupera, M., van der Flier, A., Wijelath, E.S., Murray, J., Sobel, M., Costell, M., Takahashi, S., Faessler, R., Yamaguchi, Y., Gutmann, D.H., Hynes, R.O and Gerhardt, H. (2011). Integrin-dependent and independent functions of astrocytic fibronectin in retinal angiogenesis. Development 138(20):4451-63. Epub 2011 Aug 31. PMCID: PMC3177315
  15. Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L. (2011). GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res. 71(16):5558-5568. 2011 Jul 1. [Epub ahead of print] PMCID: PMC3156271
  16. Xie, L., Duncan, M. B., Pahler, J., Sugimoto, H., Martino, M., Lively, J., Mundel, T.M., Soubasakos,M., Rubin, K., Takeda, T., Inoue, M., Lawler, J., Hynes, R.O., Hanahan, D. and Kalluri, R. (2011). Counterbalancing Angiogenic Regulatory Factors Control the Rate of Cancer Progression and Survival in a Stage-Specific Manner. Proc. Natl. Acad. Sci. USA 108(24):9939-9944. EPub ahead of print May 27. PMCID: PMC3116421
  17. Pulina, M.V., Hou, S.Y., Mittal, A., Julich, A., Whittaker, C.A., Holley, S.A., Hynes, R.O. and Astrof, S. (2011). Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev. Biol. 354(2):208-220. Apr 2. (Epub ahead of print). PMCID: PMC3225965
  18. Liu, H., Ong, S-E., Badu-Nkansah, K., Schindler, J., White, F.M. and Hynes, R.O. (2011). CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc. Natl. Acad. Sci. USA, 108:1379-1384; published online ahead of print January 10, 2011. doi:10.1073/pnas.1017228108 PMCID: PMC3029734
  19. Acharya, M., Mukhopadhyay, S., Paidassi, H., Jamil, T., Chow, C., Kissler, S., Stuart, L., Hynes, R.O. and Lacy-Hulbert, A. (2010). alpha(v) integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120(12):4445-4452. PMCID: PMC2993596
  20. Canault, M., Certel, K., Schatzberg, D., Wagner, D.D. and Hynes, R.O. (2010). The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLOS One 15;5(10):e13433. PMCID: PMC2955552
  21. van der Flier, A., Badu-Nkansah, K., Whittaker, C.A., Crowley, D., Bronson, R.T., Adam Lacy-Hulbert, A. and Hynes, R.O. (2010). Endothelial integrins in developmental angiogenesis and vascular remodeling. Development 137:2439-2449. PMCID: PMC2889609
  22. Xu, L., Begum, S., Barry, M. Crowley, D. and Hynes, R.O. (2010). GPR56 plays complex roles in endogenous cancer progression. Clin. Exp. Metastasis 27:241-249. PMCID: PMC3065979
  23. Marchetti, G., Escuin, S., van der Flier, A., Hynes, R.O. and Georges-Labouesse, E.N. (2010). Integrin α5β1 is necessary for regulation of cell morphology and radial migration of cortical neurons during mouse brain development. Eur. J. Neurosci. 31:399-409. PMCID: PMC3460545
  24. Hynes. The Extracellular Matrix: Not Just Pretty Fibrils. Science (2009) vol. 326 (5957) pp. 1216-1219. PMCID: PMC3536535
  25. Hori, Y., Stern, P., Hynes, R.O. and Irvine, D.J. (2009). Engulfing tumors with synthetic extracellular matrices for tumor immunotherapy and analysis of local anti-tumor immune responses. Biomaterials 30:6757-6787. PMCID: PMC2788234
  26. Sobolev, O., Stern, P., Lacy-Hulbert, A., Hynes, R. O. (2009). Natural killer cells use selectins for suppression of subcutaneous tumors. Cancer Res. 69:2531-2539. (Epub ahead of print, Mar 3). PMCID: PMC2694740
  27. Astrof, S. and Hynes, R.O. (2009). Fibronectins in Vascular Morphogenesis. Angiogenesis. 12(2):165-75. Epub 2009 Feb 14. PMCID: PMC2716138
  28. Hynes, R.O. (2008). US policies on human embryonic stem cells. Nature Reviews Molecular Cell Biology 9: 993-997.
  29. Stern, P., Astrof, S., Erkeland, S.J., Schustak, J., Sharp, P.A. and Hynes, R.O. (2008). A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA 105:13895-13900. PMCID: PMC2532697
  30. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L. (2008). EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1. J. Biol. Chem. 283: 2858-2870. doi: 10.1074/jbc.M708306200
  31. Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O. (2008). Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769. PMCID: PMC2756991
  32. Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R.O., Walsh, C.A., Corfas, G. and Piao, X. (2008) GPR56 regulates pial basement membrane integrity and cortical lamination. J. Neurosci. 28:5817-5826. PMCID: PMC2504715
  33. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008). Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747. PMCID: PMC2408432
  34. Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008). Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer. Clin. Exp. Metastasis 25: 109-118. PMCID: PMC3252392
  35. Astrof, S., Crowley, D. and Hynes, R.O. (2007).  Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24. PMCID: PMC2080666
  36. Hynes, R.O. (2007). Cell-matrix adhesion in vascular development. J. Thromb. Haemostasis. 5(Suppl.1) 32-40. PMID: 17635706
  37. Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007). Protein 4.1B suppresses prostate cancer progression and metastasis. Proc. Natl. Acad. Sci. USA 104: 12784-12789. PMCID: PMC1924789
  38. Astrof, S., Kirby, A., Lindblad-Toh, K, Daly, M. and Hynes, R.O. (2007). Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech. Devel. 124:551-8. PMID: 17628448
  39. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007). a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880. PMCID: PMC2064286
  40. Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007). Importance of donor- and recipient-derived selectins in cardiac allograft rejection. J. Am. Soc. Nephrol. 18:2929-2936. doi: 10.1681/ASN.2006111261
  41. Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6(2):160-5.
  42. Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006). The echinoderm adhesome. Dev. Biol. 300: 252-266.
  43. Wong, S.Y. and Hynes, R.O. (2007). Tumor-lymphatic interactions in an activated stromal microenvironment. J. Cell Biochem. 101:840-50.
  44. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L. (2007). In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109:3284-90.
  45. McCarty, J.H. and Hynes, R.O. (2007). Endothelial cell integrins. in Endothelial Biomedicine, Aird, W.C (Ed.). Cambridge University Press, Cambridge and New York.