Integrins - in vivo

  1. Gupton,SL, Riquelme, D, Hughes-Alford, SK, Tadros, J, Rudina, SS, Hynes, RO, Lauffenburger, D. and Gertler, FB. (2012). Mena binds α5 integrin directly and modulates α5β1 function. J. Cell Biol. 198(4):657-676. PMCID:PMC3514034
  2. Acharya, M., Mukhopadhyay, S., Paidassi, H., Jamil, T., Chow, C., Kissler, S., Stuart, L., Hynes, R.O. and Lacy-Hulbert, A. (2010). alpha(v) integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120(12):4445-4452. PMCID: PMC2993596
  3. van der Flier, A., Badu-Nkansah, K., Whittaker, C.A., Crowley, D., Bronson, R.T., Adam Lacy-Hulbert, A. and Hynes, R.O. (2010). Endothelial integrins in developmental angiogenesis and vascular remodeling. Development 137:2439-2449. PMCID: PMC2889609
  4. Marchetti, G., Escuin, S., van der Flier, A., Hynes, R.O. and Georges-Labouesse, E.N. (2010). Integrin α5β1 is necessary for regulation of cell morphology and radial migration of cortical neurons during mouse brain development. Eur. J. Neurosci. 31:399-409. PMCID: PMC3460545
  5. McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008). Genetic ablation of av integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747. PMCID: PMC2408432
  6. Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007). b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transplant. 7: 1080-1090.
  7. Lacy-Hulbert, A., Smith, A.M., Tissire, H., Barry, M., Crowley, D., Bronson, R.T., Roes, J.T., Savill, J.S. and Hynes, R.O.  (2007).  Ulcerative colitis and impaired clearance of apoptotic cells induced by loss of myeloid av integrins. Proc. Natl. Acad. Sci. USA 104: 15823-15828. PMCID: PMC1994135
  8. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  9. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007). a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880. PMCID: PMC2064286
  10. McCarty, J.H. and Hynes, R.O. (2006).  Endothelial cell integrins. in The Endothelium: A Comprehensive Reference.  Ed. William C. Aird.  Cambridge University Press, New York.
  11. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  12. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
  13. Staquet, M-J., Couble, M-L., Romeas, A., Connolly, M., Magloire, H., Hynes, R.O., Clezardin, P., Bleicher, F. and Farges, J-C.  (2006).  Expression and localisation of av integrins in human odontoblasts.    Cell and Tissue Res. 323:457-463.
  14. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  15. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).   A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.        Blood 107:2976-2983.
  16. McCarty, J.H., Cook, A. and Hynes, R.O. (2005). A novel interaction between avb8 integrin and band 4.1B via a highly conserved region of the band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. USA. 102:13479-13483.
  17. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D., Savill, J., Roes, J. and Hynes, R.O. (2005). Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 132: 165-176.
  18. Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Lacy-Hulbert, A., Hynes, R.O. and Hodivala-Dilke, K. (2005). Accelerated re-epithelialisation in β3-integrin-deficient mice: A novel mechanism for the regulation of TGFβ1-mediated signalling by β3-integrin. Nat. Med. 11: 167-174 .
  19. Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
  20. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  21. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased primary tumor growth in mice null for β3- or β3/β5-integrins or selectins. Proc. Natl. Acad. Sci. USA 101: 763-768.
  22. Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Xiao, Q. and Hodivala-Dilke, K. (2003). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.
  23. Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R. (2003). Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis αVβ3 integrin. Cancer Cell 3: 589-601.
  24. McCarty, J.H., Monahan-Earley, R.A., Dvorak, A.M., Brown, L.F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Wolburg, H., Bader, B.L., Dvorak, H.F. and Hynes, R.O. (2002). Defective associations between blood vessels and developing neuronal parenchyma lead to cerebral hemorrhage in mice lacking αv integrins. Mol. Cell. Biol. 22: 7667-7677.
  25. Francis, S.E., Goh, K.L., Hodivala-Dilke, K., Bader, B.L., Stark, M., Davidson, D. and Hynes, R.O. (2002). Central roles of a5b1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis and Vasc. Biol. 22: 927-933.
  26. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002). αvβ3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
  27. Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K. (2002). Enhanced pathological angiogenesis in mice lacking β3-integrin or β3- and β5-integrins. Nature Medicine 8: 27-34.
  28. DiPersio, C.M., Trevithick, J.E. and Hynes, R.O. (2001). Functional comparison of the a3A and a3B cytoplasmic domain variants of the chicken a3 integrin subunit. Exp. Cell Res. 268: 45-60.
  29. Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
  30. Haack, H. and Hynes, R.O. (2001). Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Devel. Biol. 233:38-55.
  31. DiPersio, C.M., van der Neut, R., Georges-Labouesse, E., Kreidberg, J.A., Sonnenberg, A. and Hynes, R.O. (2000) a3b1 and a6b4 integrin receptors for laminin-5 are not required for epidermal morphogenesis during skin development. J. Cell Sci. 113: 3051-3062.
  32. Arroyo, A.G., Taverna, D.T., Whittaker, C., Strauch, U., Bader, B.L., Rayburn, H., Crowley, D, Parker, C. and Hynes, R.O. (2000). In vivo roles of a4 integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for a5, αv and a4 integrins. J. Immunology 165: 4667-4675.
  33. McHugh, K., Hodivala-Dilke, K., Zheng, M.H., Namba, N., Lam, J., Novack, D., Feng, X., Ross, F.P., Hynes, R.O. and Teitelbaum, S.L. (2000). Mice lacking β3 integrins are osteosclerotic due to dysfunctional osteoclasts. J. Clin. Invest. 105: 433-440.
  34. Arroyo, A.G., Yang, J.T., Rayburn, H. and Hynes, R.O. (1999). a4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity 11: 555-566.
  35. Yang, J.T., Bader, B.L., Kreidberg, J.A., Ullman-Culleré, M., Trevithick, J.E. and Hynes, R.O. (1999). Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Devel. Biol. 215: 264-277.
  36. Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B.L., Hynes. R.O., Zhang, Y., Manova, K., and Benezra, R. (1999). Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumor xenografts. Nature 401: 670-677.
  37. Anderson, R., Fässler, R., Georges-Labouesse, E., Hynes, R.O., Bader, B., Kreidberg, J.A., Schaible, K., Heasman, J. and Wylie, C. (1999). Mouse primordial germ cells lacking b1 integrins enter the germ line but fail to migrate normally to the gonads. Development 126: 1655-1664.
  38. Hodivala-Dilke, K.M., McHugh, K., Tsakiris, D.A., Rayburn, H., Crowley, D. , Ullman-Culleré, M., Ross, F.P., Coller, B.S., Teitelbaum, S. and Hynes, R.O. (1999). β3-integrin-deficient mice: a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J.Clin. Invest. 103: 229-238.
  39. Taverna, D., Disatnik, M.H., Rayburn, H., Bronson, R.T., Rando, T.A., Yang, J.T. and Hynes, R.O. (1998). Dystrophic muscle in mice chimeric for expression of α5 integrin. . J. Cell Biol. 143: 849-859.
  40. Taverna, D., Ullman-Culleré, M., Rayburn, H., Bronson, R.T. and Hynes, R.O. (1998). A test of the role of α5 integrin/fibronectin interactions in tumorigenesis. Cancer Res., 58: 848-853.
  41. Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O. (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all αv integrins. Cell 95: 507-519.
  42. Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
  43. Goh, K.L., Yang, J.T. and Hynes, R.O. (1997) Mesodermal defects and cranial neural crest apoptosis in a5 integrin-null embryos Development 124:4309-4319.
  44. DiPersio, C. M., Hodivala-Dilke, K.M., Jaenisch, R. Kreidberg, J.A., and Hynes, R. O. (1997). α3β1 integrin is required for normal development of the epidermal basement membrane J. Cell Biol., 137: 729-742
  45. Yang, J. T and Hynes, R. O. (1996) Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by αv integrins. Mol. Biol. of the Cell 7:1737-1748.
  46. Yang, J. T., Rando, T., Rayburn, H.. Blau, H. and Hynes, R. (1996) Genetic analysis of a4 integrin functions in the development of mouse skeletal muscle. J.Cell Biol. 135:829-835.
  47. Arroyo, A. G., Yang, J. T., Rayburn, H. and Hynes, R. O. (1996) Differential requirements for a4 integrins during fetal and adult hematopoiesis. Cell 85: 997-1008.
  48. Stepp, M.A., Urry, L.A. and Hynes, R.O. (1994). Expression of a4 integrin mRNA and protein and fibronectin in the early chicken embryo. Cell Adhes. and Commun. 2:359-375.
  49. Yang, J.T., Rayburn, H. and Hynes , R. O. (1995). Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 121:549-560.
  50. Yang, J.T., Rayburn, H. and Hynes, R.O. (1993) Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119:1093-1105.