Fibronectins - Structure/Function Molecular Biology

  1. Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L.  (2008).  EIIIA (ED-A), the alternatively spliced segment of fibronectin, exhibits cryptic cell adhesive activity to integrin α9β1.  J. Biol. Chem. 283: 2858-2870.
  2. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  3. Astrof, S., Crowley, D., George, E.L., Fukuda, T., Sekiguchi, K., Hanahan, D. and Hynes, R.O. (2004). Direct test of potential roles of EIIIA and EIIIB alternatively spliced variants of fibronectin in physiological and tumor angiogenesis. Mol. Cell Bio. 19: 8662-8670.
  4. Hynes, R.O. (1999) The dynamic dialogue between cells and matrices: implications of fibronectin's elasticity. Proc. Natl. Acad. Sci. USA 96: 2588-2590
  5. Hynes, R.O. (1999). Fibronectins. in: Guidebook to the Extracellular Matrix, Anchor and Adhesion Proteins. 2nd Ed. Kreis, T. and Vale, R., eds. Sambrook and Tooze Publishers., Oxford University Press pp.422-425.
  6. Bloom, L., Ingham, K.C. and Hynes, R.O. (1999) Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol. Biol. Cell 10:1521-1536.
  7. Hedjran, F., Yeakley, J.M., Huh, G.S., Hynes, R.O., and Rosenfeld, M.G. (1997). Control of alternative splicing by distributed pentameric repeats. Proc. Natl. Acad. Sci. USA 94: 12343-12347.
  8. Huh, G.S. and Hynes, R.O. (1994). Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes and Devel. 8:1561-1574.
  9. Huh, G. and Hynes, R.O. (1993). Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol. Cell. Biol. 13:5301-5314.
  10. DeSimone, D.W., Norton, P.A. and Hynes, R.O. (1992). Expression and alternative splicing of Xenopus fibronectin mRNA. Dev. Biol. 149:357-369.
  11. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120 kDa protein. Cell Regulation 2:951-964.
  12. Guan, J.-L. and Hynes, R.O. (1990). Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor a4b1. Cell 60:51-63.
  13. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1990). Retroviral expression of alternatively spliced forms of rat fibronectin. J. Cell Biol. 110:833-847.
  14. Schwarzbauer, J.E., Mulligan, R.C. and Hynes, R.O. (1987). Efficient and stable expression of recombinant fibronectin polypeptides. Proc. Natl. Acad. Sci. USA. 84:754-758.
  15. Schwarzbauer, J.E., Patel, R.S., Fonda, D. and Hynes, R.O. (1987). Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J. 6:2673-2580
  16. Patel, R.S., Odermatt, E., Schwarzbauer, J.E. and Hynes, R.O. (1987). Organization of the rat fibronectin gene provides evidence for "exon shuffling" during evolution. EMBO J. 6:2565-2572.
  17. Paul, J.I., Schwarzbauer, J.E., Tamkun, J.W. and Hynes, R.O. (1986). Cell-type-specific fibronectin subunits generated by alternative splicing. J. Biol. Chem. 261:12258-12265.
  18. Odermatt, E., Tamkun, J.W. and Hynes, R.O. (1985). The repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation. Proc. Natl. Acad. Sci. USA. 82:6571-6575.
  19. Schwarzbauer, J.E., Paul, J.I. and Hynes, R.O. (1985). On the origin of species of fibronectin. Proc. Natl. Acad. Sci. USA, 81:1424-1428.
  20. Paul, J.I. and Hynes, R.O. (1984). Multiple fibronectin subunits and their posttranslational modifications. J. Biol. Chem. 21:13477-13487.
  21. Tamkun, J.W., Schwarzbauer, J.E. and Hynes, R.O. (1984). A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proc. Natl. Acad. Sci. USA 81:5140-5144.
  22. Schwarzbauer, J.E., Tamkun, J.W., Lemischka, I.R. and Hynes, R.O. (1983). Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell 35:421-431.
  23. Lahαv, J., Schwartz, M.A. and Hynes, R.O. (1982). Analysis of platelet adhesion using a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31:253-262
  24. Bing, D.H., Almeda, S., Isliker, H., Lahαv, J. and Hynes, R.O. (1982). Fibronectin binds to the Clq component of complement. Proc. Natl. Acad. Sci. USA 79:4198-4201.
  25. Wagner, D.D., Ivatt, R., Destree, A.T. and Hynes, R.O. (1981). Similarities and differences between the fibronectins of normal and transformed hamster cells. J. Biol. Chem. 256:11708-11715.
  26. Atherton, B.T. and Hynes, R.O. (1981). A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell 25:133-141.
  27. Wagner, D.D. and Hynes, R.O. (1980). Topological arrangement of the major structural features of fibronectin. J. Biol. Chem. 255:4304-4312.
  28. Wagner, D.D. and Hynes, R.O. (1979). Domain structure of fibronectin and its relation to function. J. Biol. Chem. 254:6746-6754.