Integrins - Cellular and Molecular

  1. Hynes, R.O. (2007).  Cell-matrix adhesion in vascular development.  J. Thromb. Haemostasis. 5(Suppl.1) 32-40.
  2. Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007).  a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
  3. Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007).  b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transpl. 7: 1080-1090.
  4. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  5. McCarty, J.H. and Hynes, R.O. (2006).  Endothelial cell integrins. in The Endothelium: A Comprehensive Reference.  Ed. William C. Aird.  Cambridge University Press, New York.
  6. McCarty, J.H. and Hynes, R.O. (2006) . Integrins and formation of the microvasculature  in  Encyclopedia of the Microvasculature. Shepro, D. (editor), Elsevier Academic Press.
  7. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.        Blood 107:2976-2983.
  8. Taverna, D., Crowley, D., Connolly, M., Bronson, R.T. and Hynes, R.O.  (2005). A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas.  Cancer Res. 65: 10324-10329.
  9. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., and Wilcox, D.A.  (2005). Therapeutic expression of the platelet-specific integrin, aIIbb3, in a murine model for Glanzmann thrombasthenia. Blood. 106:2671-2679.
  10. Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Hynes, R.O., Lacy-Hulbert, A. and Hodivala-Dilke, K.  (2005). Accelerated re-epithelialisation in b3-integrin-deficient mice is associated with enhanced TGFb1-mediated signaling. Nat. Med. 11: 167-174.
  11. McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D.H., Savill, J. and Hynes, R.O.  (2005).  Selective ablation of av integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.  Development 132:165-176.
  12. McCarty, J.H., Cook, A. and Hynes, R.O. (2005). A novel interaction between αvβ8 integrin and band 4.1B via a highly conserved region of the band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. USA. 102:13479-13483.
  13. Taverna, D., Moher, H., Crowley, D., Borsig.L., Varki, A. and Hynes, R.O. (2004). Increased tumor growth in mice null for b3- or b3/b5-integrins or selectins. . Proc. Natl. Acad. Sci. USA. 101: 763-768.
  14. Singh, P., Reimer, C., Peters, J.H., Stepp, M.A., Hynes, R.O. and Van De Water, L. (2004). The spatial and temporal expression pattern of integrin α9β and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. J.Invest. Dermatol. 123:1176-1181.
  15. Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338. PMCID: 3493146
  16. Hynes, R.O. (2003). Changing Partners Science: Vol. 300: 755-756 (in Perspectives).
  17. Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O.  and  Leong, J.M  (2003).  Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis.        Blood . 102:2843-50
  18. Hynes, R.O. (2002) Integrins: bi-directional, allosteric, signaling machines. Cell. Vol. 110: 673-687.
  19. Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002). αvbeta;3-integrin-dependent endothelial cell-specific protein synthesis inhibitor from vascular basement membrane. Science 295: 140-143.
  20. DiPersio, C.M., Trevithick, J.E. and Hynes, R.O. (2001) Functional comparison of the a3A and a3B cytoplasmic domain variants of the chicken a3 integrin subunit. Exp. Cell Res. 268: 45-60.
  21. DiPersio, C.M., Shao, M., Di Costanzo, L., Kreidberg, J.A., and Hynes, R.O. (2000). Mouse keratinocytes immortalized with large T antigen acquire a3b1integrin-dependent secretion of MMP-9/Gelatinase B. J. Cell Sci. 113: 2909-2921.
  22. Saoncella, S., Echtermeyer, F., Denhez, F., Nowlen, J.K., Mosher , D.F., Robinson, S.D., Hynes, R.O. and Goetinck, P.F. (1999). Syndecan-4 signals cooperatively with integrins, in a Rho-dependent manner, in the assembly of focal adhesions and actin stress fibers in fibronectin-null fibroblasts. Proc. Natl. Acad. Sci. USA 96: 2805-2810.
  23. Hodivala-Dilke, K.M, DiPersio, C. M., Kreidberg, J.A., and Hynes, R. O. (1998). Novel roles for a3b1 integrin as a regulator of cytoskeletal asssmbly and as a transdominant inhibitor of integrin receptor function in mouse keratinocytes. J. Cell Biol. 142: 1357-1369.
  24. Clark, E.A., King,W.G., Brugge, J.S., Symons, M. and Hynes, R.O. (1998) Integrin-mediated signals regulated by members of the Rho family of GTPases. J. Cell Biol. 142: 573-586.
  25. DiPersio, C. M., Hodivala-Dilke, K.M., Jaenisch, R. Kreidberg, J.A., and Hynes, R. O. (1997). a3b1 integrin is required for normal development of the epidermal basement membrane J. Cell Biol., 137: 729-742
  26. Clark, E. A. and Hynes, R.O. (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem. 271: 14814-14818.
  27. DiPersio, C.M., Shah, S. and Hynes, R.O. (1995). a3Ab1 integrin localizes to focal contacts in response to diverse extracellular ligands. J. Cell Sci. 108:2321-2336.
  28. Hynes, R.O. (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69:11-25.
  29. Hynes, R.O., and Plantefaber, L.C. (1991). Integrin receptors for extracellular matrix and their involvement in oncogenic transformation. In Origins of Human Cancer: A Comprehensive Review (Brugge, J., Curran, T., Harlow, E and McCormick, F.). Plainview, NY: Cold Spring Harbor. pp. 293-307.
  30. Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120 kDa protein. Cell Regulation 2:951-964.
  31. Marcantonio, E.E., Guan, J.-L., Trevithick, J.E. and Hynes, R.O. (1990). Mapping of the functional determinants of the integrin b1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation 1:597-604.
  32. Solowska, J., Guan, J.-L., Marcantonio, E.E., Trevithick, J.E., Buck, C.A. and Hynes, R.O. (1989). Expression of normal and mutant αvian integrin subunits in rodent cells. J. Cell Biol. 109:853-861.
  33. Plantefaber, L.C. and Hynes, R.O. (1989). Changes in integrin receptors on oncogenically transformed cells. Cell 56:281-290.
  34. Hynes, R.O., Marcantonio, E.E., Stepp, M.A., Urry, L.A. and Yee, G. (1989). Integrin heterodimer and fibronectin receptor complexity in αvian and mammalian cells. J. Cell Biol. 109:409-420.
  35. Marcantonio, E.E. and Hynes, R.O. (1988). Antibodies to the conserved cytoplasmic domain of the integrin b1 subunit react with proteins in vertebrates, invertebrates and fungi. J. Cell Biol. 106:1765-1772.
  36. DeSimone, D.W. and Hynes, R.O. (1988). Xenopus integrins: structural conservation and evolutionary divergence of integrin b subunits. J. Biol. Chem. 263:5333-5340.
  37. Hynes, R.O. (1987). Integrins: a family of cell surface receptors. Cell, 48:549-554.
  38. Tamkun, J.W., DeSimone, D.W., Fonda, D., Patel, R.S., Buck, C., Horwitz, A.F. and Hynes, R.O. (1986). Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 46:271-282.
  39. Gardner, J.M. and Hynes, R.O. (1985). Interaction of fibronectin with its receptor on platelets. Cell 42:439-448.