Publications for Download

• Labelle M, Hynes RO. The Initial Hours of Metastasis: The Importance of Cooperative Host–Tumor Cell Interactions during Hematogenous Dissemination. Cancer Discov. 2012 Dec;2(12):1091-9. doi: 10.1158/2159-8290.CD-12-0329. Epub 2012 Nov 19. PMCID: PMC3540992
• Reticker-Flynn, N.E., Malta, D.F.B., Winslow, M.M., Lamar, J.M., Xu, M.J., Underhill, G.H., Hynes, R.O., Jacks, T.E., and Bhatia, S.N. (2012). A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications 3, 1122. PMID:23047680
• Naba A, Hoersch S, Hynes RO. (2012) Towards definition of an ECM parts list: An advance on GO categories. Matrix Biol. 2012. Sep;31(7-8):371-2. doi: 10.1016/j.matbio.2012.11.008.
• Li, L., Welser-Alves, J.V., van der Flier, A., Boroujerdi, A., Hynes, R.O. and Milner, R. (2012). An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp. Neurol. [Epub ahead of print, Jun 18, 2012]. PMID:22721769
• Naba, A., Clauser, K.R., Hoersch, S., Liu, H., Carr, S.A. and Hynes, R.O. (2012). The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics. 11(4): M111.014647. Published online Dec. 9, 2011. PMCID: PMC3322572
• Hynes, R.O., and Naba, A. (2012). Overview of the Matrisome—An Inventory of Extracellular Matrix Constituents and Functions. In Extracellular Matrix Biology (eds. R.O. Hynes and K.M. Yamada). Cold Spring Harb Perspect Biol 3: a004903. doi:10.1101/cshperspect.a004903
• Bergmeier, W., and Hynes, R.O. (2012). Extracellular Matrix Proteins in Hemostasis and Thrombosis. In Extracellular Matrix Biology (eds. R.O. Hynes and K.M. Yamada). Cold Spring Harb Perspect Biol 3:a005132. doi:10.1101/cshperspect.a005132.
• Hynes, R.O. (2011). Metastatic cells will take any help they can get. Cancer Cell 20: 689-690. doi:10.1016/j.ccr.2011.11.022. PMCID: PMC3462586.
• Labelle M, Begum S, and Hynes RO. (2011). Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. Cancer Cell. 2011 Nov 15;20(5):576-90. PMCID: PMC3487108
• Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. (2011). GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res. 2011 Jul 1. [Epub ahead of print]
• Pulina, M.V., Hou, S.Y., Mittal, A., Julich, A., Whittaker, C.A., Holley, S.A., Hynes, R.O. and Astrof, S. (2011). Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev. Biol. 354(2):208-220. Epub 2011 Apr 3.PMID:21466802
• Xie, L., Duncan, M. B., Pahler, J., Sugimoto, H., Martino, M., Lively, J., Mundel, T.M., Soubasakos,M., Rubin, K., Takeda, T., Inoue, M., Lawler, J., Hynes, R.O., Hanahan, D. and Kalluri, R. (2011). Counterbalancing Angiogenic Regulatory Factors Control the Rate of Cancer Progression and Survival in a Stage-Specific Manner. Proc. Natl. Acad. Sci. USA, 108(24):9939-9944. Epub 2011 May 27. PMID: 21622854
• Liu, H., Ong, S-E., Badu-Nkansah, K., Schindler, J., White, F.M. and Hynes, R.O. (2011). CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc. Natl. Acad. Sci. USA, 108:1379-1384; published online ahead of print January 10, 2011. doi:10.1073/pnas.1017228108. PMID: 21220330
• van der Flier, A., Badu-Nkansah, K., Whittaker, C.A., Crowley, D., Bronson, R.T., Adam Lacy-Hulbert, A. and Hynes, R.O. (2010). Endothelial integrins in developmental angiogenesis and vascular remodeling. Development 137:2439-2449. PMID: 20570943
• Marchetti, G., Escuin, S., van der Flier, A., Hynes, R.O. and Georges-Labouesse, E.N. (2010). Integrin a5b1 is necessary for regulation of cell morphology and radial migration of cortical neurons during mouse brain development. Eur. J. Neurosci. 31:399-409. PMCID: PMC3460545
• Xu, L., Begum, S., Barry, M. Crowley, D. and Hynes, R.O. (2010). GPR56 plays complex roles in endogenous cancer progression. Clin. Exp. Metastasis 27:241-249. PMID: 20333450
• Canault, M., Certel, K., Schatzberg, D., Wagner, D.D. and Hynes, R.O. (2010). The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLOS One 15;5(10):e13433. PMID: 20976179
• Acharya, M., Mukhopadhyay, S., Paidassi, H., Jamil, T., Chow, C., Kissler, S., Stuart, L., Hynes, R.O. and Lacy-Hulbert, A. (2010). alpha(v) integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 120(12):4445-4452. PMID: 21099114
• Sobolev et al. Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors. Cancer Research (2009) vol. 69 (6) pp. 2531-2539
• Astrof and Hynes. Fibronectins in vascular morphogenesis. Angiogenesis (2009) vol. 12 (2) pp. 165-175
• Hynes, R.O. (2009) The Extracellular Matrix: not just pretty fibrils. Science 326: 1216-1219. PMCID: PMC3536535
• Hynes. Cell-matrix adhesion in vascular development. J Thromb Haemost (2007) vol. 5 Suppl 1 pp. 32-40
• Hynes, R.O. (2008). US policies on human embryonic stem cells. Nature Reviews Molecular Cell Biology, Advance Online Publication, published online 9 October 2008; doi: 10.1038/nrm2528.
• Stern, P., Astrof, S., Erkeland, S.J., Schustak, J., Sharp, P.A. and Hynes, R.O. (2008). A system for Cre-regulated RNA interference in vivo. Proc. Natl. Acad. Sci. USA 105:13895-13900.
• Li, S., Jin, Z., Koirala, S., Bu, L., Xu, L., Hynes, R.O., Walsh, C.A., Corfas, G. and Piao, X. (2008). GPR56 regulates pial basement membrane integrity and cortical lamination, J. Neurosci. 28:5817-5826.
• McCarty, J.H., Barry, M., Crowley, D., Bronson, R.T., Lacy-Hulbert, A. and Hynes, R.O. (2008). Genetic ablation of ±v integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am. J. Path. 172:1740-1747.
• Shinde, A.V., Bystroff, C., Wang, C., Vincent, P.A., Vogelezang, M.G., Hynes, R.O. and Van De Water, L.  (2008). Identification of the Peptide Sequences within the EIIIA (EDA) Segment of Fibronectin That Mediate Integrin α9β1-dependent Cellular Activities.  J. Biol. Chem. 283: 2858-2870.
• Wong, S.Y., Crowley, D, Bronson, R.T. and Hynes, R.O. (2008).  Analyses of the Role of Endogenous SPARC in mouse models of prostate and breast cancer.  Clin. Exp. Metastasis 25: 109-118.
• Xu, L., Shen, S., Hoshida, Y., Subramanian, A., Ross, K., Brunet, J.P., Ramaswamy, S., Mesirov, J.P. and Hynes, R.O.  (2008).  Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 6:760-769.
• Izawa, A., Ueno, T., Jurewicz, M., Ito, T., Tanaka, K., Takahashi, M., Ikeda, U., Sobolev, O., Fiorina, P., Smith, R.N., Hynes, R.O. and Abdi, R. (2007).  Importance of donor- and recipient-derived selectins in cardiac allograft rejection.  J. Am. Soc. Nephrol. 18:2929-2936.
• Wong, S.Y. and Hynes, R.O. (2007).  Tumor-lymphatic interactions in an activated stromal microenvironment.     J. Cell Biochem. 101: 840-850.
• Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290.
• Xu, L. and Hynes, R.O. (2007). GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 6:160-165.
• Lacy-Hulbert, A., Ueno, T., Ito, T., Jurewicz, M., Izawa, A., Smith, R.N., Chase, C.M., Tanaka, K., Fiorina, P., Russell, P.S., Auchincloss, H., Sayegh, M.H., Hynes, R.O. and Abdi, R. (2007). b3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.  Am. J. Transplant. 7: 1080-1090.
• Eshghi, S., Vogelezang, M.G., Hynes, R.O., Griffith, L.G. and Lodish, H.F. (2007). a4b1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J. Cell Biol. 177: 871-880.
• Astrof, S., Kirby, A., Lindblad-Toh, K., Daly, M.J. and Hynes, R.O. (2007).  Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four.  Mech. Dev. 124: 551-558.
• Wong, S.Y., Haack, H., Kissil, J.L., Barry, M., Bronson, R.T., Shen, S.S., Whittaker, C.A., Crowley, D, and Hynes, R.O. (2007).  Protein 4.1B suppresses prostate cancer progression and metastasis.  Proc. Natl. Acad. Sci. USA 104: 12784-12789.
• Astrof, S., Crowley, D. and Hynes, R.O. (2007).  Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Devel. Biol. 311: 11-24.
• Lacy-Hulbert, A., Smith, A.M., Tissire, H., Barry, M., Crowley, D., Bronson, R.T., Roes, J.T., Savill, J.S. and Hynes, R.O.  (2007).  Ulcerative colitis and impaired clearance of apoptotic cells induced by loss of myeloid av integrins. Proc. Natl. Acad. Sci. USA 104: 15823-15828.
• Hynes R. (2007).  Reply to 'UK set to reverse stance on research with chimeras'. Nat Med. 13:1133.
• Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.  Blood 107:2976-2983.
• Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006).  Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles.  Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
• Xu, L., Begum, S., Hearn, J.D. and Hynes, R. O.  (2006).  GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.  Proc. Natl. Acad. Sci. USA.  103: 9023-9028.
• Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
• Whittaker, C.A., Bergeron, K.F., Whittle, J., Brandhorst, B.P., Burke, R.D. and Hynes R. O. (2006).  The echinoderm adhesome.  Dev. Biol. 300: 252-266.
• Sodergren et al. The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science (2006) vol. 314 (5801) pp. 941-952
• Reynolds, L., Conti, F.A., Lucas, M. Grose, R., Robinson, S., Stone, M., Saunders, G.,C. Dickson, C., Hynes, R.O., Lacy-Hulbert, A. and Hodivala-Dilke, K.  (2005). Accelerated re-epithelialisation in b3-integrin-deficient mice is associated with enhanced TGFb-mediated signaling. Nat. Med. 11: 167-174.
• McCarty, J.H., Lacy-Hulbert, A., Charest, A., Bronson, R.T., Crowley, D., Housman, D.H., Savill, J. and Hynes, R.O. (2005). Selective ablation of av integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132:165-176.
• Taverna, D., Crowley, D., Connolly, M., Bronson, R.T. and Hynes, R.O.  (2005). A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas.  Cancer Res. 65: 10324-10329. doi: 10.1158/0008-5472.CAN-04-4098
• Wong, S.Y., Haack, H., Crowley, D., Barry, M., Bronson, R.T. and Hynes. R.O. (2005). Tumor-secreted VEGF-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res. 65: 9789-9798.
• Hamano, Y., Zeisberg, M., Sugimoto, H., Lively, J.C., Maeshima, Y., Yang, C., Hynes, R.O., Werb, Z., Sudhakar, A. and Kalluri, R.  (2003). Physiological levels of tumstatin, a fragment of collagen IV a3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via aVb3 integrin Cancer Cell  3:589-601.
• Hynes, R.O. (2004). The emergence of integrins: a personal and historical perspective. Matrix Biology 23: 331-338.
• Hynes, R.O. (2003).  Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants—or both?  Cell 113: 821-823.
• Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O. and Leong, J.M (2003). Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis. Blood. 102:2843-50.
• Hynes, R.O. (2002).  Integrins: bi-directional, allosteric, signaling machines. Cell : 110:673-687.
• Hynes, R.O. (2002).  A reevaluation of integrins as regulators of angiogenesis.  Nature Medicine 8: 918-921.
• Andre, P., Srinivasa, P., Denis, C.V., Papalia, J.M., Hynes, R.O., Phillips, D.R. and Wagner, D.D. (2002). CD40L stabilizes arterial thrombi by a β3-integrin-dependent mechanism. Nature Medicine 8: 247-252.
• Andre, P., Denis, C.V., Ware, J., Saffaripour, S., Hynes, R.O., Ruggeri, Z.M. and Wagner, D.D. (2000). Platelets adhere and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood 96: 3322-3328.
• Reynolds, L., Wyder, L., Lively, J.C., Taverna, D., Robinson, S.D., Huang, X., Sheppard, D, Hart, I., Hynes, R.O. and Hodivala-Dilke, K.  (2002). Enhanced pathological angiogenesis in mice lacking b3-integrin or b3- and b5-integrins.   Nature Medicine 8: 27-34.
• Maeshima, Y., Sudhakar, A., Lively, J.C., Ueki, K., Kharbanda, S., Kahn, C.R., Sonenberg, N., Hynes, R.O. and Kalluri, R. (2002). Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295: 140-143
• Francis, S.E., Goh, K.L., Hodivala-Dilke, K., Bader, B.L., Stark, M., Davidson, D. and Hynes, R.O. (2002). Central roles of a5b1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis and Vasc. Biol. 22: 927-933.
• Taverna, D. and Hynes, R.O. (2001). Reduced blood vessel formation and tumor growth in α5 integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61:5255-5261.
• Clark, E.A., Golub, T.R., Lander, E. and Hynes, R.O. (2000)   Genomic analysis of metastasis reveals an essential role for rhoC. .  Nature, 406: 532-535.
• Hynes, R.O., Bader, B.L. and Hodivala-Dilke, K. (1999) Integrins in vascular development. Brazilian J. Medical and Biological Res..32:501-510.
• Arroyo, A.G., Yang, J.T., Rayburn, H. and Hynes, R.O. (1999). a4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo.  Immunity  11: 555-566.
• Hynes, R.O.   (1999).   Cell adhesion: old and new questions.   Trends Millenium Issue.  M33-37.
• Bader, B.L., Rayburn, H., Crowley, D. and Hynes, R.O.  (1998) Extensive vasculogenesis, angiogenesis and organogenesis precede lethality in mice lacking all av integrins.  Cell 95: 507-519.
• Hynes, R.O. and Bader, B.L. (1997) Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. and Haem. 78:83-87.
• George, E.L., Baldwin, H.S. and Hynes, R.O. (1997). Fibronectins are essential for heart and blood vessel morphogenesis, but are dispensible for initial specification of precursor cells. Blood 90: 3073-3086.
• Arroyo, A. G., Yang, J. T.,  Rayburn, H. and Hynes, R. O. (1996) Differential requirements for a4 integrins during fetal and adult hematopoiesis.  Cell  85: 997-1008.
• Yang, J.T., Rayburn, H. and Hynes, R.O. (1993) Embryonic mesodermal defects in α5-integrin-deficient mice. Development 119:1093-1105.
• George, E.L., Georges-Labouesse, E.N., Patel-King, R.S., Rayburn, H. and Hynes, R.O. (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079-1091.
• Rees, D.J.G. Ades, S.A., Singer, S.J. and Hynes, R.O.  (1990).  Sequence and domain organization of talin, a member of a family of submembranous cytoskeletal proteins.  Nature  347: 685-689. 
• Ali, I.U. and Hynes, R.O.  (1978). Role of disulfide bonds in the attachment and function of large, external, transformation-sensitive glycoprotein at the cell surface. Biochem. Biophys. Acta 510:140-150.

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