Thrombosis & Hemostasis

  1. Bergmeier, W., and Hynes, R.O. (2012). Extracellular Matrix Proteins in Hemostasis and Thrombosis. In Extracellular Matrix Biology (eds. R.O. Hynes and K.M. Yamada). Cold Spring Harb Perspect Biol 3:a005132. Published online September 21, 2011. doi:10.1101/cshperspect.a005132.
  2. Zou, Z., Chen, H., Schmaier, A.A., Hynes R.O. and Kahn, M.L.  (2007).   In vivo structure-function analysis reveals discrete b3 integrin inside-out and outside-in signaling pathways in platelets. Blood 109: 3284-3290
  3. Yang, H., Reheman. A., Chen, P., Zhu, G., Hynes, R.O., Freedman, J., Wagner, D.D. and Ni, H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.  J. Thromb. Haemost. 4:2230-2237.
  4. Matuskova, J., Chauhan, A.K., Cambien, B., Astrof, S., Dole, V.S., Piffath, C.L., Hynes, R.O. and Wagner, D.D. (2006).  Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis and Vasc. Biol. 26: 1391-1396.
  5. Ni, H., Chen, P., Spring, C.M., Semple, J.W., Lazarus, A.H., Hynes, R.O. and Freedman, J. (2006).  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood 107:2976-2983.
  6. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., and Wilcox, D.A. (2005). Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia. Blood. 106:2671-2679. PMCID: PMC1895311
  7. Alugupalli, K.R., Michelson A.D., Joris, I., Schwan, T.G., Hodivala-Dilke, K., Hynes, R.O. and Leong, J.M (2003). Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever Borreliosis. Blood. 102:2843-50.
  8. Ni, H., Yuen, P.S.T., Papalia, J.M., Trevithick, J.E., Sakai, T., Fässler, R., Hynes, R.O. and Wagner, D.D. (2003) Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc. Natl. Acad. Sci. USA 100: 2415-2419. PMCID: PMC151355
  9. Andre, P., Srinivasa, P., Denis, C.V., Papalia, J.M., Hynes, R.O., Phillips, D.R. and Wagner, D.D. (2002). CD40L stabilizes arterial thrombi by a β3-integrin-dependent mechanism. Nature Medicine 8: 247-252.
  10. Andre, P., Denis, C.V., Ware, J., Saffaripour, S., Hynes, R.O., Ruggeri, Z.M. and Wagner, D.D. (2000). Platelets adhere and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood 96: 3322-3328.
  11. Ni, H., Denis, C.V., Subbarao, S., Sato, T.N., Degen, J.L., Hynes, R.O. and Wagner, D.D. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand and fibrinogen. J. Clin. Invest. 106: 385-392.
  12. Hodivala-Dilke, K.M., McHugh, K., Tsakiris, D.A., Rayburn, H., Crowley, D. , Ullman-Culleré, M., Ross, F.P., Coller, B.S., Teitelbaum, S. and Hynes, R.O. (1999). β3-integrin-deficient mice: a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J.Clin. Invest. 103: 229-238.
  13. Hynes, R.O. and Hodivala-Dilke, K. (1999) Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thrombosis and Haemostasis, 82: 481-485.
  14. Tsakiris, D.A., Smyth, S., Scudder, L., Hodivala-Dilke, K., Hynes, R.O. and Coller, B.S. (1999). Hemostasis in the mouse (Mus musculus): a review. Thrombosis and Haemostasis 81:177-188.
  15. Denis. C., Methia, N., Frenette, P.S., Rayburn, H., Ullman-Culleré, M., Hynes, R.O. and Wagner, D.D. (1998). A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc. Natl. Acad. Sci. USA. 95: 9524-9529.
  16. Hynes, R.O. (1991). The complexity of platelet adhesion to extracellular matrices. Thrombosis and Haemostasis. 66:40-43.
  17. Hynes, R.O. (1986). The interactions of fibronectin with platelets. in "Biology and Pathology of the Platelet - Vessel Wall Interactions" (G. Jolles, Y. Legrand and A.T. Nurden, eds.). Academic Press Inc., London. pp. 75-91.
  18. Lahαv, J., Schwartz, M.A. and Hynes, R.O. (1982). Analysis of platelet adhesion using a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31:253-262.
  19. Lahαv, J. and Hynes, R.O. (1981). Involvement of fibronectin, von Willebrand Factor, and fibrinogen in platelet interaction with solid substrata. J. Supramol. Struct. and Cell Biochem. 17:299-311