Laser Biomedical Research Center (LBRC)
The Laser Biomedical Research Center was established in October
1985 as a National
Research Resource Center in laser biomedicine with the support
of the Biomedical
Research Technology Program of the National
Institutes of Health and directed by the late Professor Michael S. Feld. Currently, Dr. Ramachandra R. Dasari is the PI of the Center. In the near future, Professor Peter T. C. So will be the principal investigator whereas Professor Moungi G. Bawendi, Professor Andrei Tokmakoff, and Dr. Ramachandra R. Dasari will be the co investigators.
The LBRCs mission is to develop
the basic scientific understanding and new techniques required for
advancing the clinical applications of lasers and spectroscopy. Historically, the first clinical application of spectroscopy explored at the LBRC was laser therapy of atherosclerotic coronary artery disease (CAD). Efforts to develop a smart catheter for spectroscopy-guided laser ablation of coronary plaque led to development of an LBRC program for real time in vivo spectroscopic disease diagnosis. This program began with efforts to diagnose atherosclerosis, lately with a focus on vulnerable plaque, and then expanded to the diagnosis of cancer and pre-cancer. Some of the other major achievements of the Center include:
- Identification of fluorophores such as elastin, collegen, NADH, etc. for in-vivo quantitative tissue diagnostics
- Early stage cancer detection in breast, oral cavity, and cervix using Raman spectroscopy
- Transcoutaneous real-time glucose detection using Raman spectroscopy.
- Development of portable clinical diagnostic instruments based on fluorescence, Raman, and diffused reflectance techniques
- Structural and functional changes in human red blood cells during malaria infection using quantitative phase microscopy
- 3-D structural imaging of live cells using tomographic phase microscopy
A unique feature of the LBRC is its ability to form strong clinical
collaborations with outside investigators in areas of common interest
that further the Center's mandated research objectives. As a National Research Resource Center, the LBRC makes available
its facilities, along with technical and scientific
support, to outside researchers for the purpose of pursuing independent
research projects in the area of laser biomedical applications.
The facilities are available on a time-shared basis, free-of-cost
policy to qualified scientists, engineers and physicians throughout
the United States. For additional information, please read the Guidelines
for Use of LBRC Facilities.