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Optimize a chromatography procedure using an FPLC instrument to remove residual host cell proteins, host cell DNA, and other impurities from a protein drug product.
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Develop and implement a high-throughput screening technique to assess a new chromatography medium for the removal of protein aggregates and other impurities from a protein drug product.
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Optimize an HPLC size-exclusion method for accurately and reproducibly quantifying aggregate impurities in a purified protein drug product.
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Assess the performance of chromatography steps in removing impurities and achieving high recovery yields of a protein product using ELISA methods to quantify protein product amounts and levels of host cell proteins.
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