In my PhD as a Hertz Fellow in Biophysics at Harvard, with George Church and colleagues, I co-authored experimental and theoretical papers on molecular recording devices and road-mapped approaches for whole-brain mapping. I also participated in the development of new epigenomic readout technologies, genome engineering methods, nano-fabrication methods and nano-manipulation systems. More recently, I have co-authored papers analyzing our understanding of cortical computation, seeking strategies to integrate deep learning and neuroscience, and proposing new designs for neural interfaces. In my work with Ed Boyden at MIT, I helped to initiate the field of optical connectomics using the combination of expansion microscopy, in-situ sequencing, and machine learning. At MIT, I am an investigator on an IARPA-funded project to map the neural connectome through in-situ sequencing of RNA barcodes.
Prior to my work in brain science, I studied quantum nonlocality, showing how quantum entanglement can exponentially enhance certain forms of distributed computation, and assisted in the early development of caDNAno, a graphical software tool for design of 3D DNA origami nanostructures, now the standard for the field of structural DNA nanotechnology.