Adam H Marblestone

Email: adam.h.marblestone [at] gmail

Publications: google


nm2cm integration

with George Church, Robert Barish and others

No integrated architecture has yet been proposed which fully specifies the steps necessary to produce structures with a) overall sizes on the scale of today’s computer chips (centimeters), b) addressable features on the 10 nm scale, and c) the ability to attach a wide range of discrete molecular components at customizable locations. We are investigating schemes for nanometer-to-centimeter fabrication integration via top-down organization of DNA nanorods using DNA hybridization interactions, as well as other architectures.

Thesis excerpt: PDF

Seeing a single strand of DNA

with Mingjie Dai, Ralf Jungmann and Peng Yin

In this project, we made a nanoscale "tightrope" out of a single double helix of DNA.

Thesis excerpt: PDF

Rapid prototyping of 3D DNA-origami shapes with caDNAno

with Shawn Douglas and William Shih


Publication: PDF

Repositories of open caDNAno files: OpenWetWare and

I helped to write the first version of the open-source software CADnano for design of three-dimensional scaffolded DNA origami nanostructures. Shawn Douglas led the project and has since led the development of improved versions in collaboration with AutoDesk, Digizyme, the Wyss Institute and other groups.

Exponential quantum enhancement for distributed addition with local nonlinearity

with Michel Devoret

Publication: PDF

Using quantum entanglement, it is theoretically possible to perform so-called "pseudo-telepathy": groups of separated, non-communicating individuals can perform collective tasks which would, in a non-quantum universe, absolutely require them to communicate. To do so, they must establish quantum entanglement beforehand: the prior entanglement serves as a kind of substitute for later communication. Intrigued by limited examples of such quantum pseudo-telepathy schemes, I wondered whether quantum mechanics could allow complex computations (involving chains of non-linear logic operations) to be performed using less communication than would be required classically. Michel Devoret and I showed that this was true: the non-linear logic involved in performing a distributed binary addition operation can be done using exponentially less communication than would normally be necessary, provided the parties involved share prior entanglement.

Quantum limited amplification

with Michel Devoret and Archana Kamal

Publication: PDF

I helped to design a new type of amplifier for microwave-frequency electronic signals. The device operates in a regime where macroscopic electrical quantities like voltage and current exhibit "spooky" quantum behavior.