You have made your way from worm to man, and much within you is still worm.
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Doi A, Suarez GD, Droste R, Horvitz HR (2023) A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci. Nature communications.18;14(1):6593. PDF available.
Saul J, Hirose T, Horvitz HR (2022) The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans. eLife 11 PDF available.
Dwivedi VK, Pardo-Pastor C, Droste R, Kong JN, Tucker N, Denning DP, Rosenblatt J, Horvitz HR. (2021) Replication stress promotes cell elimination by extrusion. Nature, May;593(7860):591-6. PDF available.
Ghosh DD, Lee D, Jin X, Horvitz HR & Nitabach MN. (2021) C. elegans discriminates colors to guide foraging. Science, 371(6533), 1059-1063 PDF available.
Sando SR, Bhatla N, Lee EL, Horvitz HR. (2021) An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. eLife, Jul 2;10:e59341. PDF available.
Burkhart KB, Sando SR, Corrionero A, Horvitz HR. (2020) H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect. Curr Biol. 2020 Jun 22;30(12):2343-2352.e3. PDF available.
Cohn J, Dwivedi V, Valperga G, Zarate N, de Bono M, Horvitz HR, Pierce JT. (2019) Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene egl-1 in a Living Neuron Pair in Caenorhabditis elegans. G3: Genes, Genomes, Genetics. 1;9(11):3703-14. PDF available.
Burton NO, Dwivedi VK, Burkhart KB, Kaplan RE, Baugh LR, Horvitz HR. (2018) Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. Nature communications. 2018;9. PDF available.
Corrionero A and Horvitz HR. (2018) A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis. Curr Biol. 21;28(10):1522-1535.e5. PDF available.
Engert CG, Droste R, van Oudenaarden A, Horvitz HR. (2018) A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility. PLoS Genet. 27;14(4):e1007295. other PDF available.
Pender CL and Horvitz HR. (2018) Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor. Elife. 16;7. pii: e36828. PDF available.
Van Bael S, Watteyne J, Boonen K, De Haes W, Menschaert G, Ringstad N, Horvitz HR, Schoofs L, Husson SJ, Temmerman L. (2018) Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans. J Biol Chem. 20;293(16):6052-6063. PDF available.
Burton, N.O., Furuta, T., Webster, A.K., Kaplan, R.E., Baugh, L.R., Arur, S., Horvitz, H.R. (2017) Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol 19(3):252-257. PDF available.
Driscoll, K., Stanfield, G.M., Droste, R., Horvitz, H.R. (2017) Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans. PNAS 15;114(33):8806-8811. PDF available.
Luo, S. and Horvitz, H.R. (2017) The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage. Curr Biol. 6;27(5):661-672. PDF available.
Johnsen, H.L. and Horvitz, H.R. (2016) Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans. BMC Biology 14:39. PDF available.
Paquin, N., Murata, Y., Froehlich, A., Omura, D.T., Ailion, M., Pender, C.L., Constantine-Paton, M., and Horvitz, H.R. (2016) The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior. Current Biology 26, 862-871. PDF available.
Bhatla, N. and Horvitz, H.R. (2015) Light and hydrogen peroxide inhibit C. elegans feeding through gustatory receptor orthologs and pharyngeal neurons. Neuron 85, 804-818. PDF available.
Bhatla, N., Droste, R., Sando, S.R., Huang, A. and Horvitz, H.R. (2015) Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans. Current Biology 25, 2075-2089. PDF available.
Ma D.K., Li, Z., Lu, A.Y., Sun, F., Chen, S., Rothe, M., Menzel, R., Sun, F. and Horvitz, H.R. (2015) Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell 161, 1152-1163. PDF available.
Peters, O.M., Cabrera, G.T., Tran, H., Gendron, T.F., McKeon, J.E., Metterville, J., Weiss, A., Wightman, N., Salameh, J., Kim, J., Sun, H., Boylan, K.B., Dickson, D., Kennedy, Z., Lin, Z., Zhang, Y.-J., Daughrity, L., Jung, C., Gao, F.-B., Sapp, P.C., Horvitz, H.R., Bosco, D.A., Brown, S.P., de Jong, P., Petrucelli, L., Mueller, C. and Brown, R.H. (2015) Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice. Neuron 88, 902-909. PDF available.
Hirose, T. and Horvitz, H.R. (2014) The Translational Regulators GCN-1 and ABCF-3 Act Together to Promote Apoptosis in C. elegans. PLoS Genet. Aug 7;10(8):e1004512. PDF available.
Rawson, R.L., Yam, L., Weimer, R.M., Bend, E.G., Hartwieg, E., Horvitz, H.R., Clark, S.G. and Jorgensen, E.M. (2014) Axons degenerate in the absence of mitochondria in C. elegans. Curr Biol. Mar 31;24(7):760-5. PDF available.
de la Cruz, I.P., Ma, L. and Horvitz, H.R. (2014) The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-Box to regulate the muscle two-pozre domain potassium channel SUP-9. PLoS Genet. Feb 20;10(2):e1004175. PDF available.
Denning, D., Hatch, V., Horvitz (2013) Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in C. elegans. PLoS Genet. 9(3):e1003341. PDF available.
Hirose, T. and Horvitz, H.R. (2013) An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature 500, 354-358. PDF available.
Ma, D.K., Rothe, M., Zheng, S., Bhatla, N., Pender, C., Menzel, R. and Horvitz, H.R. (2013) Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans. Science 341, 554-558. PDF available.
Suzuki, J., Denning, D., Imanishi, E., Horvitz, H.R. and Nagata, S. (2013) Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 341, 403-406. PDF available.
Anderson, C., Zhou, S., Sawin, E., Horvitz, H.R., Hurwitz M.E. (2012) SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function PLoS Genet. 8(12):e1003115. PDF available.
Boulias K and Horvitz H.R. (2012) The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO. Cell Metab. 15, 439-50. PDF available.
Denning, D., Hatch, V. and Horvitz, H.R. (2012) Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature 488, 226-230. PDF available.
Emtage, L., Aziz-Zaman, S., Padovan-Merhar, O., Horvitz, H.R., Fang-Yen, C. and Ringstad, N. (2012) IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a dedicated Go signaling pathway. J. Neuroscience 32, 16285-16295. PDF available.
Gurel, G., Gustafson, M., Pepper, J., Horvitz, H.R. and Koelle, M. (2012) Receptors and other signaling proteins required for serotonin control of locomotion in C. elegans. Genetics, Sept. 28, 112.142125 PDF available.
Klees, E. and Horvitz, H.R. (2012) Biomedical Consulting Agreements -- The Good, the Bad and the Ugly. Science Careers, Oct. 12, 10.1126/science.caredit.a1200114.
Klees, E. and Horvitz, H.R. (2012) Biomedical Consulting Agreements: A Guide for Academics. The MIT Press.
Ma, D.K., Vozdek, R., Bhatla, N. and Horvitz, H.R. (2012) CYSL-1 Interacts with the O2-sensing Hydroxylase EGL-9 to Promote H2S-modulated Hypoxia-induced Behavioral Plasticity in C. elegans. Neuron 73, 925-40. PDF available.
Ma, L., Gau, X., Luo, J., Huang, L., Teng, Y. and Horvitz, H.R. (2012) Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. PLoS Genetics, 8(7):e1002827. PDF available.
Omura, D., Clark, D., Samuel, A. and Horvitz, H.R. (2012) Dopamine signalling is essential for precise rates of locomotion by C. elegans. PLoS One 7(6):e38649. PDF available.
Davison, E., Saffer, A., Huang, L., DeModena, J., Sternberg, P. and Horvitz, H.R. (2011) The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics 187, 803-815. PDF available.
Galvin, B., Denning, D. and Horvitz, H.R. (2011) SPK-1, an SR protein kinase, inhibits programmed cell death in C. elegans. PNAS 108, 1998-2003. PDF available.
Hallem, E., Spencer, W.C., McWhirter, R., Zeller, G., Henz, S., Ratsch, G., Miller, D., Horvitz, H.R., Sternberg, P. and Ringstad, N. (2011) A receptor-type guanylate cyclase is required for carbon dioxide sensation by C. elegans. PNAS 108, 254-259. PDF available.
Harris, D. and Horvitz, H.R. (2011) MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. Development 138, 4051-4062. PDF available.
Korzelius, J., The, I., Ruijtenberg, S., Portegijs, V., Xu, H., Horvitz, H.R. and S. van den Heuvel. (2011) C. elegans MCM-4 is a general replication and checkpoint component with an epidermis-specific requirement for growth and viability. Devel. Biol. 350, 358-369. PDF available.
Ma, L., Tan, Z., Teng, Y., Hoersch, S. and Horvitz, H.R. (2011) In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Canenorhabditis elegans. RNA 17, 2201-11. PDF available.
Nakano, S., Stillman, B. and Horvitz, H.R. (2011) Replication-coupled chromatin assembly generates a bilateral asymmetry. Cell 147, 1525-36. PDF available.
Saffer, A., Kim, D.H., van Oudenaarden, A. and Horvitz, H.R. (2011) The C. elegans synthetic multivulva genes prevent Ras activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet. 7, e1002418. PDF available.
Tabuchi, T., Deplancke, B., Osato, N., Zhu, L., Barrasa, I., Harrison, M., Horvitz, H.R., Walhout, A. and Hagstrom, K. (2011) Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. PLoS Genetics 7, e1002074. PDF available.
Alvarez-Saavedra, E. and Horvitz, H.R. (2010) Many families of Caenorhabditis elegans microRNAs are not essential for development and viability. Current Biology 20, 367-373 PDF available.
Berdichevsky, A., Nedelcu, S., Boulias, K., Bishop, N., Guarente, L. and Horvitz, H.R. (2010) 3-ketoacyl thiolase delays aging in C. elegans and is required for metabolic changes and longevity mediated by sir-2.1. PNAS 107, 18927-18932. PDF available.
Hirose, T., Galvin, B. and Horvitz, H.R. (2010) Six and Eya promote apoptosis through direct transcriptional activation of the pro-apoptotic BH3-only gene egl-1 in C. elegans. PNAS 107, 15479-15484. PDF available.
Nakano, S., Ellis, R. and Horvitz, H.R. (2010) Otx-dependent expression of proneural bHLH genes establishes a nervous system bilateral asymmetry. Develop. 137, 4017-4027. PDF available.
Hurwitz M.E., Vanderzalm P.J., Bloom L., Goldman J., Garriga G., Horvitz H.R. (2009) Abl kinase inhibits the engulfment of apoptotic cells in Caenorhabditis elegans. PLoS Biol. 2009 Apr 28;7(4). PDF available.
Jospin, M., Qi, Y., Stawicki, T., Boulin, T., Schuske, K., Horvitz, H.R., Bessereau, J.-L., Jorgensen, E. and Jin, Y. (2009) A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biology 7, e1000265. PDF available.
Kwiatkowski T., Jr., Bosco, D., LeClerc, A., Tamrazian, E.,Van den Berg, C., Russ, C., Davis, A., Gilchrist, J., Kasarskis, E., Munsat, T., Rouleau, G., Hosler, B., Cortelli, P., de Jong, P., Yoshinaga, Haines, J., Pericak-Vance, M., Yan, J., Siddique, T., McKenna-Yasek, D., Sapp, P., Horvitz, H.R., Landers, J. and Brown, R., Jr. (2009) Mutations in the FUS/TLS gene on chromosome cause familial amyotrophic lateral sclerosis. Science 323, 1205-1208 PDF available.
Landers, J., Melki, J., Meininger, V., Glass, H., Van den Berg, L., van Es, M., Sapp, P., van Vught, P., McKenna-Yasek, D., Blauw, H., Cho, T.-J., Polak, M., Shi, L., Wills, A.-M., Broom, W., Ticozzi, N., Ozoguz, A., Rodriquez, I., Veldink, J., Ivinson, A., Saris, C., Hosler, B., Barnes-Nessa, A., Couture, N., Wokke, J., Kwiatkowski, T., Ophoff, R., Cronin, S., Hardiman, O., Diekstra, F., Leigh, P., Shaw, C., Simpson, C., Hansen, V., Powell, J., Corcia, P., Salachas, F., Heath, S., Galen, P., Georges, F., Horvitz, H.R., Lathrop, M., Purcell, S., Al-Chalabi, Al and Brown, R. (2009) Reduced expression of the kinesin-associated protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. PNAS 106, 9004-9009. PDF available.
Ma, L., Horvitz H.R. (2009) Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo. PLoS Genet. 2009 Nov;5(11). PDF available.
Ringstad N., Abe N., Horvitz H.R. (2009) Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science. 2009 Jul 3;325(5936):96-100. PDF available.
Simpson, C., Lemmens, R., Broom, W., Hansen, V., Landers, J., Sapp, P., Van Den Bosch, L., Knight, J., Neale, B., Tripathi, V., Shah, M., Turner, M., Proitsi, P., Van Hoecke, A., Carmeliet, P., Horvitz, H.R., Leigh, N., Shaw, C., Sham, P., Powell, J., Brown, R., Robberecht, W. and Al-Chalabi, A. (2009) Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Human Molec. Genetics 18, 472-481. PDF available.
Vanderzalm P.J., Pandey A., Hurwitz M.E., Bloom L., Horvitz H.R., Garriga G. (2009) C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development. 2009 Apr;136(7):1201-10. PDF available.
Yu H., Seah A., Herman M.A., Ferguson E.L., Horvitz H.R., Sternberg P.W. (2009) Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol. 2009 Mar 15;327(2):419-32. PDF available.
Andersen, E.C., Saffer, A.M. and Horvitz, H.R. (2008) Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates. Genetics 179(4): 2001-12. PDF available.
Choi, P., Zakhary, L., Choi, W.-Y., Caron, S., Alvarez-Saavedra, E., Miska, E., McManus, M., Harfe, B., Giraldez, A., Horvitz, H.R., Schier, A. and Dulac, C. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 57, 41-55. PDF available.
Galvin, B.D., Kim S. and Horvitz H.R. (2008) Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics 179(1):403-17. PDF available.
Ringstad, N and Horvitz, H.R. (2008) FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Nat. Neurosci. 11(10): 1168-76. PDF available.
Andersen, E. and Horvitz, H.R. (2007) Two C. elegans histone methyltransferases repress lin-3 EGF to inhibit vulval development. Development 134, 2991-2999. PDF available.
Eimar, S., Gottschalk, A., Hengartner, M., Horvitz, H.R., Richmond, J., Schafer, W. and Bessereau, J.-L. (2007) Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J., 26, 4313-4323. PDF available.
Harrison, M., Lu, X. and Horvitz, H.R. (2007) LIN-61, one of two Caenorhabditis elegans MBT-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics 176, 255-271. PDF available.
Miska, E., Alvarez-Saavedra, E., Abbott, A., Lau, N., Hellman, A., McGonagle, S., Bartel, D. Ambros, V and Horvitz, H.R. (2007) Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genetics 3(12), e215. PDF available.
Reddien, P., Andersen, E. and Horvitz, H.R. (2007) DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 Zn finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics 175, 1719-1733. PDF available.
Schwartz, H. and Horvitz, H.R. (2007) The C. elegans protein CEH-30 protects male-specific CEM neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & Develop. 21, 3181-3194. PDF available.
Andersen, E., Lu, X. and Horvitz, H.R. (2006) C. elegans ISW1 and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Development 133, 2695-2704 PDF available.
Berdichevsky, A., Viswanathan, M., Horvitz, H.R. and Guarente, L. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177 PDF available.
Ceol, C., Stegmeier, F., Harrison, M. and Horvitz, H.R. (2006) Identification and classification of genes that act antagonistically to let-60 Ras signaling in C. elegans vulval development. Genetics 173, 709-726 PDF available.
Harrison, M., Ceol, C., Lu, X. and Horvitz (2006) Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing protein complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. U.S.A. 103, 16782-16787. PDF available.
Morita, M., Al-Chalabi, A., Andersen, P., Hosler, B., Sapp, P., Englund, E., Mitchell, J, Habgood, J., de Belleroche, J., Xi, J., Jongjaroenprasert, W., Horvitz, H.R., Gunnarsson, L.-G. and Brown, R. (2006) A locus on chromosomem 9p confers susceptibility to ALS and frontotemporal dementia. Neurology 66, 839-844 PDF available.
Shah, P., Ahmad-Annuar, A., Ahmadi, K., Russ, C., Sapp, P., Horvitz, H.R., Brown, R., Goldstein, D. and Fisher, E. (2006) No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 7, 46-56 PDF available.
Su, C.-W., Tharin, S., Jin, Y., Wightman, B., Spector, M., Meili, D., Tsung, N., Rhiner, C., Bourikas, D., Stoeckli, E., Garriga, G., Horvitz, H.R. and Hengartner, M. (2006) The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. J. Biol. 5, 9.1-9.26.
Abbott, Al., Alvarez-Saavedra, E., Miska, E., Lau, N. Bertell, D., Horvitz, H.R. and Ambros, V. (2005) The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Develop. Cell 9, 403-414. PDF available.
Alkema, M., Hunter-Ensor, M., Ringstad, N. and Horvitz, H.R. (2005) Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron 46, 247-260 PDF available.
Davison, E., Harrison, M., Walhout, A., Vidal, M and Horvitz, H.R. (2005) lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics 171, 1017-1031 PDF available.
Frank, C.A., Hawkins, N., Guenther, C., Horvitz, H.R. and Garriga, G. (2005) C. elegans HAM-1 positions the cleavage plane of certain asymmetric neuroblast divisions. Develop. Biol. 284, 301-310 PDF available.
Horvitz, H.R. (2005) Stanley J. Korsmeyer (1950-2005). Nature 435, 161. PDF available.
Lu, J., Getz, G., Miska, E., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ferrando, A., Downing, J., Jacks, T., Horvitz, H.R. and Golub, T. (2005) MicroRNA expression profiles classify human cancers. Nature 435, 834-848 PDF available.
Wienholds, E., Kloosterman, W., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Tolstrup, N., Horvitz, H.R., Kauppinen, S. and Plasterk, R. (2005) MicroRNA expression in zebrafish embryonic development. Science 309, 310-311. PDF available.
Ceol, C. and Horvitz, H.R. (2004) A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Developmental Cell 6, 563-576 PDF available.
Jaeger, S. Schwartz, H., Horvitz, H.R. and Conradt, B. (2004) The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proc. Natl. Acad. Sci. U.S.A. 101, 12549-12554 PDF available.
Miska, E., Alvarez-Saavedra, E., Yoshii, A., Townsend, M., Sestan, N., Rakic, P., Constantine-Paton, M. and Horvitz, H.R. (2004) Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology 5, R68. 1-13 PDF available.
Reddien, P. and Horvitz, H.R. (2004) The engulfment process of programmed cell deaths in Caenorhabditis elegans. Ann. Rev. Cell & Develop. Bio. 20, 193-221 PDF available.
Yuan, J. and Horvitz, H.R. (2004) A first insight into the molecular mechanisms of apoptosis. Cell S116, S53-S56 PDF available.
Horvitz, H.R. (2003) H. Robert Horvitz -- Autobiography. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 284-319.
Horvitz, H.R. (2003) Worms, Life and Death: Nobel Lecture, December 8, 2002. In Les Prix Nobel; The Nobel Prizes 2002. Frangsmyr, T., ed. Edita Norstedts Tryckeri AB, Stockholm, pp. 320-351.
Horvitz, H.R. (2003) Worms, Life, and Death (Nobel Lecture) Chembiochem. 4(8), 697-711 PDF available.
Hwang, H.-Y., Olson, S., Brown, J., Esko, J and Horvitz, H.R. (2003) The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J. Biol. Chem. 278, 11735-11738. PDF available.
Hwang, H.-Y., Olson, S., Esko, J. and Horvitz, H.R. (2003) Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature 423, 439-443. PDF available.
Sapp, P., Hosler, B., McKenna-Yasek, D., Chin, W., Gann, A., Genise, H., Gorenstein, J., Huang, M., Sailer, W., Scheffler, M., Valesky, M., Haines, J., Pericak-Vance, M., Siddique, T., Horvitz, H.R. and Brown, Jr., R.H. (2003) Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. Amer. J. Human Genetics 73, 397-403. PDF available.
Thomas, J.H., Ceol, C., Schwartz, H. and Horvitz, H.R. (2003) New genes that interact with lin-35 Rb to negatively regulate the let-60 Ras pathway in Caenorhabditis elegans. Genetics 164, 135-151. PDF available.
de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz H.R. (2003) sup-9, sup-10, and unc-93 may encode components of a two-pore K channel that coordinates muscle contraction in Caenorhabditis elegans. J Neurosci. 2003 Oct 8;23(27):9133-45. PDF available.
Cameron, S., Clark S., McDermott, J., Aamodt, E. and Horvitz, H.R. (2002) PAG-3, a Zn finger transcription factor, determines neuroblast identity in C. elegans. Development 129, 1763-1774. PDF available.
Hersh, B., Hartwieg, E. and Horvitz, H.R. (2002) The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc. Natl. Acad. Sci. U.S.A., 99, 4355-4360. PDF available.
Hwang, H.-Y. and Horvitz, H.R. (2002) The C. elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. PNAS 2002 Oct 29;99(22),14224-9 PDF available.
Hwang, H.-Y. and Horvitz, H.R. (2002) The SQV-1 UDP-glucoronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect C. elegans vulval morphogenesis and embryonic development. PNAS 2002 Oct 29;99(22),14218-23 PDF available.
Tzur, Y., Hersh, B., Horvitz, H.R. and Gruenbaum. Y. (2002) Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. J. Struct. Biol. 137, 146-153. PDF available.
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Horvitz, H.R. (1974) Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase. J. Mol. Biol. 90, 739-750.
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