Publications

Original articles and reviews: Chemical Toxicology: 2000-2009

[1960-1979]   [1980-1989]   [1990-1999]   [2000-2009]   [2010-]

Contact Ms. Marcia Ross for reprints or preprints: mross@mit.edu.

W.G. Stillwell, P.L. Skipper, and S.R. Tannenbaum. 2000. Biomonitoring: Methods and Analysis. In: Food Borne Carcinogens, John Wiley & Sons, Ltd. Chapter 10, pp. 319-331.

J.C. Zhuang, T. Wright, T. deRojas-Walker, S.R. Tannenbaum, and G.N. Wogan. 2000. Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium. Environmental & Molecular Carcinogenesis 35: 39-47.

N.Y. Tretyakova, S. Burney, B. Pamir, J.S. Wishnok, P.C. Dedon, G.N. Wogan and S.R. Tannenbaum. 2000. Peroxynitrite-Induced DNA damage in the supF gene: Correlation with the Mutational Spectrum. Mutation Res. 447, 287-303.

L.J. Marnett, T.L. Wright, B.C. Crews, S.R. Tannenbaum, and J.D. Morrow. 2000. Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase. J. Biol. Chem. 275,13427-13430.

N.M. Probst-Hensch, D.A. Bell, M.A. Watson, P.L. Skipper, S.R. Tannenbaum, K.K. Chan, R.K. Ross, and M.C. Yu. 2000. N-Acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl hemoglobin adduct levels. Cancer Epidemiology, Biomarkers & Prevention 9, 619-623.

N. Tretyakova, J.S. Wishnok, and S.R. Tannenbaum. 2000. Peroxynitrite-Induced secondary oxidative lesions at guanine nucleobases: Chemical stability and recognition by the Fpg DNA repair enzyme. Chem. Res. Tox, 12, 459-466.

C.C. Ozbal, P.L. Skipper, M.C. Yu, S.J. London, R.R. Dasari and S.R. Tannenbaum. 2000. Quantification of (7S,8R)-dihydro-(9R,10S)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene adducts in human serum albumin by laser-induced fluorescence: Implications for the in vivo metabolism of benzo[a]pyrene. Cancer Epidemiology, Biomarkers, and Prevention. 9, 733-739

J.C. Niles, J.S. Wishnok and S.R. Tannenbaum. 2000. A novel nitration product formed during the reaction of peroxynitrite with 2’,3’,5’-tri-O-acetyl-7,8-dihydro-8-oxo-guanosine: N-nitro,N’-[1-(2,3,5-tri-O-acetyl-b-D-erythro-pentofuranosyl)-2,4-dioxo-imidazolidin-5-ylidene]guanidine. Chem. Res. Tox. 13, 390-396.

S.R. Tannenbaum. 2000. DNA Damage by nitrogen and oxygen free radicals and its modulation by dietary constituents. IN: Carcinogenic and Anticarcinogenic Factors in Food: Novel Concepts? Wiley-VCH, Germany, Chapter 14, 228-233 2000

E.J. Spek, T.L. Wright, M.S. Stitt, N.R. Taghizadeh, S.R. Tannenbaum, M.G. Marinus, and B.P. Engelward. 2000. Recombinational Repair is critical for the survival of Escherichia coli exposed to nitric oxide. J. Bacteriology, 183, 131-138

J.E. Castelao, J-M. Yuan, P.L. Skipper, S.R. Tannenbaum, M. Gago-Dominguez, J.S. Crowder, R.K. Ross, and M.C. Yu. 2001. Gender- and smoking-related bladder cancer risk.. JNCI, 93,
538-545.

J. Gan, P.L. Skipper, and S.R. Tannenbam. 2001. Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes. Chem. Res. Toxicol. 14 (6), 672-677.

N. Tretyakova, B. Matter, A. Ogdie, J.S. Wishnok and S.R. Tannenbaum. 2001. Location nucleobase lesions within DNA sequences of MALDI-TOF mass spectral analysis of exonuclease ladders. Chem. Res. Toxicol. 14 (8), 1058-1070.

S.R. Tannenbaum. 2001. A new paradigm for DNA damage by reactive oxygen and nitrogen species. Food & Food Ingredients Journal of Japan, 194: 5-9.

K. Jiao, S. Mandapati, P.L. Skipper, S.R. Tannenbaum, and J.S. Wishnok. 2001. Site-selective ntiration of tyrosine in human serum albumin by peroxynitrite. Anal. Biochem., 293, 43-51.

J.T. Mehl, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum. 2001. GC and LC interfaces for biological AMS. Isotopically Labelled Compounds, 7, 447-450.

J.C. Niles, J.S. Wishnok and S.R. Tannenbaum. 2001. A novel nitroimidazole compound formed during the reaction of peroxynitrite with 2',3',5'-Tri-O-acetyl-guanosine. J. Am. Chem. Soc. 123, 12147-12151.

J.C. Niles, J.S. Wishnok and S.R. Tannenbaum. 2001. Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue. Organic Letters 3 (7), 963-966

P.T. Henderson, J.C. Delaney, F. Gu, S.R. Tannenbaum, and J.M. Essigmann. 2002. Oxidation of 7,8-Dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochem., 41, 914-921.

J.M. Lee, J.C. Niles, J.S. Wishnok, and S.R. Tannebaum. 2002. Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines. Chem. Res. Toxicol. 15, 7-14.

W.M. Deen, S.R. Tannenbaum, and J.S. Beckman. 2002. Protein tyrosine nitration and peroxynitrite. Comment. FASEB J. 16, 1144.

F. Gu, W.G. Stillwell, J.S. Wishnok, A.J. Shallop, R.A. Jones and S.R. Tannenbaum. 2002. Peroxynitrite-induced reactions of synthetic oligo 2'-deoxynucleotides and DNA containing guanine: Formation and stability of a 5-guanidino-4-nitroimidazole lesion. Biochemistry 41(23):7508-7518.

W.G. Stillwell, R. Sinha, and S.R. Tannenbaum. 2002. Excretion of the N2-glucuronide conjugate of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in urine and its relationship to CYP1A2 and NAT2 activity levels in humans. Carcinogenesis, 23(5), 831-838.

M.C. Yu, P.L. Skipper, S.R. Tannenbaum, K.K. Chan, R.K. Ross. 2002. Arylamine exposures and bladder cancer risk. Mutat. Res. 506-507:21-28.

P.L. Skipper, S.R. Tannenbaum, R.K. Ross and M.C. Yu. 2002. Nonsmoking-related arylamine exposure and bladder cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 12, 503-507.

S.R. Tannenbaum and D.B. Schauer. 2003. The role of nitric oxide and oxygen radicals in colon carcinogenesis. IN: FALK Symposium No. 128, Exogenous Factors in Colonic Carcinogenesis pp 195-205.

T.L. Wright, C-Q. Li, L.J.Trudel, G.N. Wogan, and S.R. Tannenbaum. 2003. Determination of Nitric oxide-induced effects on tissue levels of glutathione and mitochondrial membrane potential. In: Methods in Enzymology, Elsevier Science (USA), 359, 319-328.

J.L. Caulfield, J.S. Wishnok and S.R. Tannenbaum. 2003. Nitric oxide-induced interstrand cross-links in DNA. Chem. Res. Toxicol. 16(5), 571-574.

G. Nikov, V. Bhat, J.S. Wishnok and S.R. Tannenbaum. 2003. Analysis of nitrated proteins by nitrotyrosine-specific affinity probes and mass spectrometry. Analytical Biochemistry, 320,214-222.

R.G. Liberman, S.R. Tannenbaum, B.J. Hughey, R.E. Shefer, R.E. Klinkowstein, C. Prakash, S.P. Harriman, and P.L. Skipper. 2004.An interface for direct analysis of 14C in non-volatile samples by Accelerator Mass Spectrometry. Analytical Chemistry. 76(2), 328-334, 2004.

H.Yu, J Wishnok, and S Tannenbaum. 2003. Synthesis of 3,7,8, 15N3-N1-(B-D-eryt-hro-pentofuranosyl)-5-guanidinohydantoin.. Journal of Labelled Compounds and Radiopharmaceuticals 46: 1269-1277.

P.T. Henderson, J.C. Delaney, J.G.Muller, W.L. Neeley, S.R. Tannenbaum, C.J. Burrows, J.M. Essigmann. 2003. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42(31):9257-62.

J. Kim and S.R.Tannenbaum 2003. S-nitrosation regulates the activation of endogenous procaspase-9 in HT-29 human colon carcinoma cells. Journal of Biological Chemistry 279 (11),9758-64.

R.G. Liberman B.J. Hughey, P.L. Skipper, J.S. Wishnok, R.E. Klinkowstein, R.E. Shefer, and S.R. Tannenbaum. 2004. The NSI Biomedical AMS Sytsem at MIT: Current Status. Nuclear Instruments and Methods in Physics Research – B, 223-224, 82-86

P.L. Skipper, B.J. Hughey, R.G. Liberman, M.H. Choi, J.S. Wishnok, R.E. Klinkowstein, R.E. Shefer, and S.R. Tannenbaum. 2004. Bringing AMS into the Bioanalytical Chemistry Lab. Nuclear Instruments and Methods in Physics Research – B, 223-224, 740-744

J Castelao, J-M Uan, M Dominguez, P Skipper, S Tannenbaum, K Chan, et al. 2004. Carotenoids/Vitamin C and Smoking-related Bladder Cancer. Int. Journal of Cancer 110, 417-423

P Dedon and S R Tannenbaum. 2004. Reactive Nitrogen Species in the Chemical Biology of Inflammation. Arch. Biochem & Biophys. 423,12-22.

J.Niles, J.S.Wishnok and S.R. Tannenbaum 2004. Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: kinetic and mechanistic studies with 18O. Chem. Res. Toxicol. 17 (11),1510-9.

J.Niles, J.S.Wishnok and S.R. Tannenbaum 2004. Mass Spectrometric Identification of 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid during One-Electron Oxidation of 8-oxoguanosine by Peroxynitrite and KHSO5/CoCl2. Chem. Res. Toxicol. 17 (11), 1501-9.

J Gan, P.L. Skipper, M. Gago-Dominguez, K Arakawa, R. Ross, M. Yu and S.R. Tannenbaum 2004. Alkylaniline-Hemoglobin Adducts and Risk of Nonsmoking-related Bladder Cancer. Journal of National Cancer Institute. 96 (19), 1425-31

H. Yu, J. Niles, J.S. Wishnok, and S. R. Tannenbaum 200 4. Spirodihydantoin is a Minor Product of 5-Hydroxyisourate in Urate Oxidation. Organic Letters 6 (19), 3417-3420

D. Farkas and S.R.Tannenbaum 2005. In vitro methods to study chemically-induced hepatotoxicity: A literature review. Current Drug Metabolism 6,111-125

J. Kim and S.R.Tannenbaum 2004. Insulin regulates cleavage of procaspase-9 via binding of X Chromosome-linked Inhibitor of Apoptosis Protein in HT-29 cells. Cancer Research 64,9070-9075

M. H. Choi, P.L. Skipper, J.S. Wishnok, S.R. Tannenbaum 2004. Characterization of testosterone 11ß-hydroxylation catalyzed by human-liver microsomal cytochromes P450. Drug Metabolism and Disposition. 33 (6), 714-8

P.T. Henderson, W.L. Neeley, J.C. Delaney, F Gu, J.C. Niles, S.R. Tannenbaum and J.M. Essigmann 2005. Urea lesion formation in DNA produced by 7,8-dihydro-8-oxoguanine oxidation hydrolysis: a novel pathway to a potent source of point mutations. Chem. Res. Toxicol. 18,12-18

D. Farkas, V. Bhat, S. Mandapati and S.R.Tannenbaum 2005. Characterization of the Secreted Proteome of Rat Hepatocytes Cultured in Collagen Sandwiches. Chem. Res. Toxicol. 18, 1132-9

X. Zhou, R. Liberman, P.L. Skipper, Y. Margolin, S.R. Tannenbaum and P.C. Dedon 2005. Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: Application to ?–radiation and peroxynitrite. Analytical Biochemistry.
343,84-92.

D. Farkas and S.R.Tannenbaum 2005. Characterization of Chemically Induced Hepatotoxicity in Collagen Sandwiches of Rat Hepatocytes. Toxicological Sciences. 85,927-34

J. Kim, S.R.Tannenbaum, and F. White. 2005 Global phosphoproteome of HT-29 Human Colon Adenocarcinoma Cells. Journal of Proteome Research. 4,1339-1346

V. Bhat, M.H. Choi, J.S. Wishnok and S.R. Tannenbaum 2005. Comparative Plasma Proteome Analysis of Lymphoma-Bearing SJL Mice. Journal of Proteome Research. 4 (5), 1814-25

H. Yu, L. Venkatarangan, J.S.Wishnok and S.R. Tannenbaum 2005. Quantitation of Four Oxidation Products from Reaction of DNA with Varying Doses of Peroxynitrite. Chem. Res.Toxicology Dec 18 (12): 1849-57

J.Niles, J.S.Wishnok and S.R. Tannenbaum 2005.Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide. 14 (2), 109-121.

S. R. Tannenbaum and Ji-Eun Kim 2004. Controlled S-nitrosation. Nat. Chem. Bio. 1(2), 2-3

A.Sivaraman, J.K.Leach, S. Townsend, T. Lida, B.J. Hogan, D.B.Stolz, R.Fry, L.D.Samson, S.R.Tannenbaum, LG.Griffin 2005. A Microscale in vitro Physiological Model of the Liver: Predictive Screens for Drug Metabolism and Enzyme Induction. Current Drug Metabolism.
6 (6), 569-591

C. Li, T.L. Wright, M. Dong, Y.E.M.Dommels, L.J. Trudel, P.C. Dedon, S.R. Tannenbaum, G.N. Wogan. 2005. Biological role of glutathione in nitric oxide-induced toxicity in cell culture and animal models. Free Radical Biology & Medicine 39, 1489-1498

P.L. Skipper, L.J. Trudel, T.W.Kensler, J.D.Groopman, P.A.Egner, R.G.Liberman, G.N.Wogan and S.R.Tannenbaum. 2006. DNA Adduct Formation by 2,6-Dimethyl-,3,5-Dimethyl-, and 3-Ethylaniline In Vivo in Mice. Chem. Res.Toxicology, 19 (8), 1086-90.

R.G. Liberman, P.L. Skipper, Chandra Prakash, Christopher L Shaffer, Jimmy Flarakos, and S.R. Tannenbaum. 2007. BEAMS Lab: A balance between high throughput and high sensivity. Nuclear Instruments and Methods in Physics Research – B, 259, 773-778.

H.G. Jang, M. Park, J.S.Wishnok, S.R.Tannenbaum and G.N. Wogan. 2006. Hydroxyl Specific Fluorescence Labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine and ADB1-formamidopyrimidine with BODIPY-FL. Analytical Biochemistry, 359(2), 151-60.

M.H. Kristiansson, V.B. Bhat, I.R. Babu, J.S. Wishnok, and S.R. Tannenbaum. 2007. Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice. Journal of Proteome Research, 2007 March 8.

R.G. Liberman, U.J. Becker, and P.L. Skipper 2006. A gas-multiplication telescope detector for low-energy ions. Nuclear Instruments and Methods in Physics Research 565, 686-690.

S.R. Tannenbaum and F.M. White.  2006. Regulation and Specificity of S-Nitrosylation and Denitrosylation.  ACS Chemical Biology, 1 (10), 615-618.

M.V. Williams, J.S. Wishnok, and S.R. Tannenbaum.  2006. Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presences of cytrochrome C.  Chemical Research in Toxicology; 2007 April 4.

S.M. Hillier, J.C. Marquis, B. Zayas, J.S. Wishnok, R.G. Liberman, P.L. Skipper, S.R. Tannenbaum, J.M. Essigmann and R. G. Croy.  2006. DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo. Mol. Canc. Ther. 5, 977-984.

B. Zayas, S.W. Stillwell,  J.S. Wishnok, L.J. Trudel, P.L. Skipper, M.C. Yu, S.R. Tannenbaum, and G.N. Wogan. 2007. Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients. Carcinogenesis 28(2), 342-9.

B. Pang, X. Zhou, H. Yu, M. Dong, K. Taghizadeh, J.S. Wishnok, S.R. Tannenbaum, and P.C. Dedon.  2007.  Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.  Carcinogenesis 28(8), 1807-13.

Xuejuan Jiang, Jian-Min Yuan, Paul L. Skipper, Steve R. Tannenbaum, Mimi C. Yu.  2007.  Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County.  Cancer Research 67, 7540-7545.

K. Watanabe, R.G. Liberman, P.L. Skipper, S.R. Tannenbaum, and F.P. Guengerich.  2007.  Analysis of DNA Adducts Formed In vivo Rats and Mice from 1,2-Dibromoethane, 1,2-Dichloroethane, Dibromomethane, and Dichloromethane Using HPLC/Accelerator Mass Spectrometry and Relevance to Risk Estimates.  Chemical Research in Toxicology 20 (11), 1594-600.

C. Yates, C.R. Shepard, G. Papworth, A. Dash, D. Beer-Stolz, S.R. Tannenbaum, L. Griffith, and A. Wells.  2007.  Novel Three-Dimensional Organotypic Liver Bioreactor to Directly Visualize Early Events in Metastatic Progression.  Advances in Cancer Research 97, 225-246.

L. Cui, H. Sun, J. S. Wishnok, S. R. Tannenbaum, and P. L. Skipper.  2007.  Identification of adducts formed by reaction of N-acetoxy-3,5-dimethylaniline with DNA.  Chemical Research in Toxicology 20(11), 1730-6.

C. Prakash, C.L. Shaffer, L.M. Tremaine, R.G. Liberman, P.L. Skipper, J Flarakos, and S.R. Tannenbaum. 2007. Application of Liquid Chromatography-Accelerator Mass Spectrometry (LC-AMS) to Evaluate the Metabolic Profiles of a Drug Candidate in Human Urine and Plasma. Drug
Metabolism Letters I, 226-231.

M.V. Williams, J.S. Wishnok, and S.R. Tannenbaum. 2007. Covalent adducts arising from the decomposition products of lipid hydroperoxides in the presences of cytrochrome C. Chemical Research in Toxicology. 20(5):767-75.

M.H. Kristiansson, V.B. Bhat, I.R. Babu, J.S. Wishnok and S.R. Tannenbaum. 2007. Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice. Journal of Proteome Research. 6(5):1735-44.

J. Fu, R.B. Schoch, A.L Stevens, S.R. Tannenbaum, J.  Han. 2007. A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins. Nature Nanotechnol, 2(2): 121-8. 

A.L. Stevens C.A. Wheeler, S.R. Tannenbaum, A.J. Grodzinsky. 2007. Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants. Osteoarthritis Cartilage 16(4):489-97. 

J. Flarakos, R.G. Liberman, S.R. Tannenbaum, P.L. Skipper. 2008. Integration of continuous flow accelerator mass spectrometry with chromatography and mass-selective detection. Anal Chem  80(13):5079-85.

J. H. Lee, Y.A. Song, S.R. Tannenbaum, J. Han. 2008. Increase of reaction rate and sensitivity of low-abundance enzyme assay using micro/nanofluidic preconcentration chip. Anal Chem  80(9): 3198-3204.

C.G. Knutson, P.L. Skipper, R.G. Liberman, S.R. Tannenbaum, L.J. Marnett. 2008. Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1dG {3-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one}, by accelerator mass spectrometry. Chem Res Toxicol. 21(6), 1290-1294.

A. Stevens, J. Wishnok,  D. Chai, A. Grodzinsky, S.R. Tannenbaum. 2008. A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta.  Arthritis and Rheumatism 58(2): 489-500.

S.E. Erdman V.P. Rao, T. Poutahidis, A.V. Rogers, C.L. Taylor, E.A. Jackson, Z. Ge, C.W. Lee, D.B. Schauer, G.N. Wogan, S.R. Tannenbaum, J.G. Fox. 2009. Nitric oxide and TNF-trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected Rag2-deficient mice. Proc Natl Acad Sci USA,106(4): 1027-32.  

A. Stevens, J.S. Wishnok, F.M. White, A.J. Grodzinsky, S.R. Tannenbaum. 2009. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Protem. 8(7):1475-89.

A. Dash, W. Inman, K. Hoffmaster, S. Sevidal, J. Kelly, R.S. Obach, L.G. Griffith, S.R. Tannenbaum. 2009. Liver tissue engineering in the evaluation of drug safety. Expert Opin Drug Metab Toxicol. 5(10):1159-74.

J. G. Fox Y. Feng, E. J. Theve, R.C. Fry, J. L  Fiala, A.L. Doernte, M. Williams, A.R. Raczynski, J.L. McFaline, J.M. Essigmann, D.B. Schauer, S.R. Tannenbaum, P.C. Dedon, S.A. Weinman, Lemon, A.B. Rogers. 2009. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut. 59(1):88-97.

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