NSE - Nuclear Science & Engineering at MIT


Rajiv Gupta

Rajiv (Raj) Gupta



Personal website
Lab website


Rajiv (Raj) Gupta, PhD, MD is the Enterprise Medical Director of Neuroradiology for Mass General Brigham, Division Chief for Neuroradiology at the Massachusetts General Hospital (MGH), an Associate Professor of Radiology at the Harvard Medical School, and a Lecturer in Nuclear Science and Engineering at MIT. He also directs the Advanced X-ray Imaging Sciences (AXIS) Center at MGH. Raj earned his MD at Cornell University, his PhD in Computer Science at the University at Stony Brook, and MSc Honors (Physics) and BE Honors (Electrical Engineering) from BITS, Pilani. Raj was a Computer Scientist at General Electric conducting research in X-ray imaging, non-destructive evaluation of aircraft engine parts, and computer vision. He also served on the faculty of the University of Southern California, Los Angles in EE-Systems. His research is focused on radiation physics and clinical applications of novel technologies to medical imaging.


My research is focused on three main topics: (1) development and clinical applications of novel X-ray imaging modalities including 5th Generation CT, ultra-high resolution CT, phase contrast X-ray imaging, and dual-energy CT; (2) development of low-cost devices for imaging and image-guided interventions; and (3) study of traumatic brain injury (TBI) using advanced, quantitative MRI techniques.

My lab is building a prototype Static CT system that can be deployed in resource-poor environments. In another project, we are investigating the use of transcranial near-infrared light as a therapy for TBI. Besides multiple government sponsored research grants, I have been an investigator on numerous industry-sponsored clinical trials and have participated in several large industry-sponsored trials. For example, my lab is clinically evaluating a unique photon-counting CT scanner for stroke and other applications.  I am also the imaging PI for a Phase III clinical trial (ClinicalTrials.gov Identifier: NCT00000550) running at nearly 100 sites world-wide that is testing the efficacy of Clazosentan for vasospasm after aneurysmal subarachnoid hemorrhage.

University of Wisconsin-Madison, Department of Radiology Advisory Board


Recent Publications

  1. Yuenyongsinchai K, Tan CO, Vranic J, Flores E, Silverman S, Gupta R. Carotid Plaque Characterization Using Dual Energy Computed Tomography: Predicting Imminent Ipsilateral Ischemic Stroke in 30 Days. Originally published7 Jun 2022https://doi.org/10.1161/SVIN.121.000313Stroke: Vascular and Interventional Neurology. 2022;0:e000313
  2. Vranic JE, Harker P, Stapleton CJ, Regenhardt RW, Dmytriw AA, Alotaibi NM, Gupta R, Leslie-Mazwi TM, Koch MJ, Raymond SB, Mascitelli JR, Patterson TT, Seinfeld J, White A, Case D, Roark C, Gandhi CD, Al-Mufti F, Cooper J, Patel AB. Determinants of intracranial aneurysm retreatment following embolization with a single flow-diverting stent. Neuroradiol J. 2022 Aug;35(4):461-467. PMID: 34747246, PMCID: PMC9437496, https://doi.org/10.1177/19714009211049086
  3. Avesta A, Yendiki A, Perlbarg V, Velly L, Khalilzadeh O, Puybasset L, Galanaud D, Gupta R. Synergistic Role of Quantitative Diffusion Magnetic Resonance Imaging and Structural Magnetic Resonance Imaging in Predicting Outcomes After Traumatic Brain Injury. J Comput Assist Tomogr. 2022 Mar-Apr;46(2):236-243. PMID: 35297580, PMCID: PMC8974470, https://doi.org/10.1097/RCT.0000000000001284
  4. Lai A, Tan CO, Vranic J, Weidauer S, Leslie-Mazwi T, Hirsch JA, Gupta R. Clazosentan for Improvement of Time to Peak Perfusion in Patients with Angiographically Confirmed Severe Vasospasm. Neurocrit Care. 2022 Feb;36(1):240-247. PMID: 34296399, https://doi.org/10.1007/s12028-021-01291-4
  5. Kamezawa C, Cramer A, Krull W, Yashiro W, Hyodo K, Gupta R. Dynamic X-ray elastography using a pulsed photocathode source. Sci Rep. 2021 Dec 16;11(1):24128. PMID: 34916531, PMCID: PMC8677743, https://doi.org/10.1038/s41598-021-03221-y
  6. Haines MS, Kimball A, Meenaghan E, Bachmann KN, Santoso K, Eddy KT, Singhal V, Ebrahimi S, Dechant E, Weigel T, Ciotti L, Keane RJ, Gleysteen S, Mickley D, Bredella MA, Tan CO, Gupta R, Misra M, Schoenfeld D, Klibanski A, Miller KK. Sequential Therapy With Recombinant Human IGF-1 Followed by Risedronate Increases Spine Bone Mineral Density in Women With Anorexia Nervosa: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2021 Nov;36(11):2116-2126. PMID: 34355814, PMCID: PMC8595577, https://doi.org/10.1002/jbmr.4420
  7. Gupta M, Burns EJ, Georgantas NZ, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Burns RP, Velarde J, Jordan JT, Frigault MJ, Nahed BV, Jones PS, Barker FG, Curry WT, Gupta R, Batchelor TT, Romero JM, Brastianos PK, Marble HD, Martinez-Lage M, Tateishi K, Lennerz JK, Dietrich J, Cahill DP, Carter BS, Shankar GM. A rapid genotyping panel for detection of primary central nervous system lymphoma. Blood. 2021 Aug 5;138(5):382-386. PMID: 33735913, PMCID: PMC8343545, https://doi.org/10.1182/blood.2020010137
  8. Shimao D, Sunaguchi N, Yuasa T, Ando M, Mori K, Gupta R, Ichihara S. X-ray Dark-Field Imaging (XDFI)-a Promising Tool for 3D Virtual Histopathology. Mol Imaging Biol. 2021 Aug;23(4):481-494. PMID: 33624229, https://doi.org/10.1007/s11307-020-01577-7
  9. Khalilzadeh O, Glover M, Torriani M, Gupta R. Imaging Assessment of Thoracic Outlet Syndrome. Thorac Surg Clin. 2021 Feb;31(1):19-25. PMID: 33220768, https://doi.org/S1547-4127(20)30076-1
  10. Ando M, Gupta R, Iwakoshi A, Kim JK, Shimao D, Sugiyama H, Sunaguchi N, Yuasa T, Ichihara S. X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications. Phys Med. 2020 Nov;79:188-208. PMID: 33342666, https://doi.org/S1120-1797(20)30309-4